Portal:AOP/Mission

From WikiPathways

The purpose of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the EU-ToxRisk program, in which Open PHACTS Foundation (OPF) is responsible for AOP creation. The subjects of the first AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.

The proposed list of the first set of AOPs to be created:

• Inhibition of β-oxidation leads to liver steatosis
• HDAC inhibition, folate antagonism and oxidative stress lead to teratogenicity
• Oxidative stress leads to hepatotoxicity
• Oxidative stress leads to nephrotoxicity
• Disturbance of the respiratory chain leads to mitotoxicity
• PPAR activation leads to hepatoxicity
• OAT overactivation leads to nephrotoxicity
• PXR activation leads to liver steatosis
• NAPQI production causes hepatotoxicity
• MTP impairment leads to hepatotoxicity
• CYP51 inhibition causes embryotoxicity
• Epithelial damage leads to popcorn lung

Basic strategies and principles for general AOPs are described in this paper:

Villeneuve et al. (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. Toxicological Sciences PubMed