Protein alkylation leading to liver fibrosis (Homo sapiens)

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MIE: Protein alkylation (KE244)Collagen accumulationStressorsProtein alkylationKER 269FibronectinACTA2retinolMAPK3FASLGMAPK8MMP2SMAD1TIMP4ApoptosisTNFMAPK1CCL2thioacetamideCOL1A1SMAD3MMP1TIMP2NFKB1COL4A1NFKB2reactive oxygen speciesCa2+SMAD7Collagen biosynthesis and modifying enzymesSMAD5TNFSF10CCl4Apoptosis Modulation and SignalingPPARGTIMP1TGFB1PDGFRBMMPTIMP3Granulocyte-macrophage colony-stimulating factorIL6Transcription factor p65Proto-oncogene c-RelHyaluronic acidSMAD2CTGFMMP3PDGFRACOL1A2COL4A6allyl alcoholRELBCOL3A1IL1AMMPIToll-like Receptor Signaling PathwayTNF alpha Signaline PathwayDimethylnitrosamineCD163IFNGKE1: Cell injury/death (KE55)Histone H2AXCytochrome CAIF1BH3-interacting domain death agonistBAXCalpain-1 catalytic subunitTNFPARP1MAPK13Nitric oxide synthaseAPAF1Caspase-3Caspase-9KE2: Increased activation and recruitment of Kupffer Cells (KE134)TNFMAPK9MAPK11MAPK12MAPK14TGFB1reactive oxygen speciesFASLGKER 67KE3: TGFbeta1 expression up regulation (KE276)TGFB1KER 147KE4: Stellate cell activation (KE265)BiglycanCOL4A5COL4A4COL4A3COL4A2DecorinTenascinglycosaminoglycanTGFB1KER 304KE5: Collagen accumulation (KE68)COL4A1COL3A1COL1A2COL4A6COL1A1COL4A5COL4A4COL4A3COL4A2KER 295AO: Liver Fibrosis (KE344)COL4A1COL1A2COL4A6COL1A1COL4A5COL4A4COL4A3COL4A2TIMP2TIMP1


Description

Protein alkylation leading to liver fibrosis This pathway is based on descriptive text of the adverse outcome pathway (AOP) on https://aopwiki.org/aops/38

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Quality Tags

Ontology Terms

 

Bibliography

  1. Horvat T, Landesmann B, Lostia A, Vinken M, Munn S, Whelan M; ''Adverse outcome pathway development from protein alkylation to liver fibrosis.''; Arch Toxicol, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125572view13:09, 28 February 2023Marvin M2created event nodes
125571view13:07, 28 February 2023Marvin M2added KE nodes
125570view12:50, 28 February 2023Marvin M2Added tgf-beta pathway
114317view16:15, 6 January 2021Marvin M2Updated layout
114316view16:06, 6 January 2021Marvin M2Renewed and removed molecular entities to follow AOP guidelines
96718view16:23, 30 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96693view15:51, 27 March 2018Marvin M2Added references to Key Events and Key Event Relationships
93134view13:39, 31 July 2017Marvin M2Added the main reference for this AOP
92321view11:11, 22 May 2017Marvin M2Ontology Term : 'liver disease pathway' added !
92320view11:04, 22 May 2017Marvin M2Ontology Term : 'liver disease' added !
92296view12:59, 19 May 2017Marvin M2Modified description
92294view12:47, 19 May 2017Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTA2GeneProductENSG00000107796 (Ensembl)
AIF1GeneProductAIF1 (HGNC)
APAF1GeneProductENSG00000120868 (Ensembl)
Apoptosis Modulation and SignalingPathwayWP1772 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
BAXGeneProductENSG00000087088 (Ensembl)
BH3-interacting domain death agonistProteinP55957 (Uniprot-TrEMBL)
BiglycanProteinP21810 (Uniprot-TrEMBL)
CCL2GeneProductCCL2 (HGNC)
CCl4MetaboliteCHEBI:27385 (ChEBI)
CD163GeneProductENSG00000177575 (Ensembl)
COL1A1GeneProductENSG00000108821 (Ensembl)
COL1A2GeneProductENSG00000164692 (Ensembl)
COL3A1GeneProductENSG00000168542 (Ensembl)
COL4A1GeneProductENSG00000187498 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
COL4A3GeneProductENSG00000169031 (Ensembl)
COL4A4GeneProductENSG00000081052 (Ensembl)
COL4A5GeneProductENSG00000188153 (Ensembl)
COL4A6GeneProductENSG00000197565 (Ensembl)
CTGFGeneProductENSG00000118523 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
Calpain-1 catalytic subunitProteinE9PRM1 (Uniprot-TrEMBL)
Caspase-3ProteinA8MVM1 (Uniprot-TrEMBL)
Caspase-9ProteinF8VWA5 (Uniprot-TrEMBL)
Collagen biosynthesis and modifying enzymesPathwayWP2725 (WikiPathways)
Cytochrome CMetaboliteCHEBI:4062 (ChEBI)
DecorinProteinF8VNW0 (Uniprot-TrEMBL)
DimethylnitrosamineMetaboliteCHEBI:34874 (ChEBI)
FASLGGeneProductENSG00000117560 (Ensembl)
FibronectinMetaboliteCHEBI:5058 (ChEBI)
Granulocyte-macrophage colony-stimulating factorProteinP04141 (Uniprot-TrEMBL)
Histone H2AXProteinP16104 (Uniprot-TrEMBL)
Hyaluronic acidMetaboliteCHEBI:5772 (ChEBI)
IFNGGeneProductENSG00000111537 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
MMPMetaboliteCHEBI:340824 (ChEBI)
MMPIMetaboliteCHEBI:50664 (ChEBI)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
Nitric oxide synthaseProteinB3VK56 (Uniprot-TrEMBL)
PARP1GeneProduct142 (Entrez Gene)
PDGFRAGeneProduct5156 (Entrez Gene)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
Proto-oncogene c-RelProteinQ04864 (Uniprot-TrEMBL)
RELBGeneProductENSG00000104856 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD5GeneProductENSG00000113658 (Ensembl)
SMAD7GeneProductENSG00000101665 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TIMP1GeneProductENSG00000102265 (Ensembl)
TIMP2GeneProductENSG00000035862 (Ensembl)
TIMP3GeneProductENSG00000100234 (Ensembl)
TIMP4GeneProductENSG00000157150 (Ensembl)
TNF alpha Signaline PathwayPathwayWP231 (WikiPathways)
TNFGeneProduct7124 (Entrez Gene)
TNFGeneProductENSG00000232810 (Ensembl)
TNFSF10GeneProductENSG00000121858 (Ensembl)
TenascinProteinE9PC84 (Uniprot-TrEMBL)
Toll-like Receptor Signaling PathwayPathwayWP75 (WikiPathways)
Transcription factor p65ProteinA0A087WVP0 (Uniprot-TrEMBL)
allyl alcoholMetaboliteCHEBI:16605 (ChEBI)
glycosaminoglycanMetaboliteCHEBI:14361 (ChEBI)
reactive oxygen speciesMetaboliteQ424361 (Wikidata)
retinolMetaboliteCHEBI:50211 (ChEBI)
thioacetamideMetaboliteQ416253 (Wikidata)

Annotated Interactions

No annotated interactions

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