Ethanol effects on histone modifications (Homo sapiens)

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GlycinemHistonesMAT1AAHCYNucleic acidsTYMSEHMT2HomocysteineSLC19A1MTRFolic aciddUMPDihydrofolateS-AdenosylmethionineMTHFRMAT IIITetrahydrofolatePyrimidines5-MTHFL-MethionineEthanol5,10-MTHFdTMPL-SerineDHFRS-AdenosylhomocysteineMitochondrial damageHATAcetaldehydeACSS2ADH1BCYP2E1ADH1AAcetateAcetyl-CoAHistones acHistonesALDH1A1Coenzyme AALDH2Reactive oxygen species2. EtOH increases histone acetylation via oxidative stressADH1CALDH1A2ALDH1A3Reactive oxygen speciesReactive oxygen species1. EtOH reduces histone methylation via one-carbon metabolism


Description

Ethanol effects on histone modifications which contribute to the development of fetal alcohol syndrome. Pathway based on Chater-Diehl et al. 2017 (https://doi.org/10.1016/j.alcohol.2017.01.005)

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Quality Tags

Ontology Terms

 

Bibliography

  1. Lee KK, Workman JL; ''Histone acetyltransferase complexes: one size doesn't fit all''; Nat Rev Mol Cell Biol., 2007 PubMed Europe PMC Scholia
  2. Chater-Diehl EJ, Laufer BI, Singh SM; ''Changes to histone modifications following prenatal alcohol exposure: An emerging picture.''; Alcohol, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125197view10:24, 29 January 2023EgonwChEBI id of the specific compound, not the class
107156view14:24, 17 September 2019MaintBotChEBI identifier normalization
106772view13:25, 17 September 2019MaintBotHMDB identifier normalization
106409view21:55, 28 August 2019KhanspersModified description
105589view04:44, 10 August 2019KhanspersModified description
93015view19:34, 24 July 2017Khanspersfixed unconnected interaction
93010view16:08, 23 July 2017FehrhartAdded annotations
93009view15:58, 23 July 2017FehrhartConnected lines
92563view10:16, 16 June 2017Fehrhartwork in progress
92562view10:06, 16 June 2017Fehrhartwork in progress
92561view10:05, 16 June 2017Fehrhartwork in progress
92525view12:57, 13 June 2017Fehrhartwork in progress
92524view11:04, 13 June 2017FehrhartModified description
92523view11:01, 13 June 2017FehrhartOntology Term : 'fetal alcohol spectrum disorder' added !
92521view08:56, 13 June 2017Marvin M2Ontology Term : 'altered histone modification pathway' added !
92520view08:49, 13 June 2017FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5,10-MTHFMetabolite
5-MTHFMetabolite
ACSS2GeneProductENSG00000131069 (Ensembl)
ADH1AGeneProductENSG00000187758 (Ensembl)
ADH1BGeneProductENSG00000196616 (Ensembl)
ADH1CGeneProductENSG00000248144 (Ensembl)
AHCYGeneProductENSG00000101444 (Ensembl)
ALDH1A1GeneProductENSG00000165092 (Ensembl)
ALDH1A2GeneProductENSG00000128918 (Ensembl)
ALDH1A3GeneProductENSG00000184254 (Ensembl)
ALDH2GeneProductENSG00000111275 (Ensembl)
AcetaldehydeMetaboliteHMDB00990 (HMDB)
AcetateMetabolite30089 (ChEBI)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
CYP2E1GeneProductENSG00000130649 (Ensembl)
Coenzyme AMetaboliteHMDB01423 (HMDB)
DHFRGeneProductENSG00000228716 (Ensembl)
DihydrofolateMetabolite67014 (ChEBI)
EHMT2GeneProductENSG00000204371 (Ensembl) G9a
EthanolMetaboliteHMDB00108 (HMDB)
Folic acidMetaboliteHMDB00121 (HMDB)
GlycineMetaboliteHMDB00123 (HMDB)
HATGeneProduct
Histones GeneProduct
HomocysteineMetaboliteHMDB00742 (HMDB)
L-MethionineMetaboliteHMDB00696 (HMDB)
L-SerineMetaboliteHMDB00187 (HMDB)
MAT IIIGeneProduct
MAT1AGeneProductENSG00000151224 (Ensembl)
MTHFRGeneProductENSG00000177000 (Ensembl)
MTRGeneProductENSG00000116984 (Ensembl)
Nucleic acidsMetabolite33696 (ChEBI)
Pyrimidines Metabolite39447 (ChEBI)
Reactive oxygen speciesMetabolite26523 (ChEBI)
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
SLC19A1GeneProductENSG00000173638 (Ensembl) Formerly known as RFC1
TYMSGeneProductENSG00000176890 (Ensembl)
TetrahydrofolateMetabolite67016 (ChEBI)
acHistonesGeneProduct
dTMPMetabolite
dUMPMetaboliteHMDB01409 (HMDB)
mHistonesGeneProduct

Annotated Interactions

No annotated interactions

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