Clear cell renal cell carcinoma pathways (Homo sapiens)

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76DEPTOR253135455Malfunction of epigenetic machineryLegendProtein TranslationEFCAB3AMPKCell proliferationSTAT3glucoseFLT1PDGFRACAMK1Fatty Acid SynthesisENPP3FASNKCNJ2EGFRHK3GlycolysisACACAPAngiogenesisAKT1MLST8SQSTM1MTORRPTORTSC1p300GRB10MePI3KMIR21MeRTKsPTENGLUT1VEGFARHEBVHLHIF1AHIF1BPBRM1SETD2BAP1KDM5CH2UbH3H3MeMeH2Activation of PI3K-mTOR pathwayTSC2HIF1BHIF1ACell migrationand invasionHIF1AHIF1BHIF1AUbPDGFBTGFB1TGFB2TGFB3CBPp300CBPAKT1S1ACACBACLYMDH1ME1HK1HK2GPIPFKLPFKPPFKMALDOAALDOBALDOCTPI1GAPDHPGK1PGK2PGM1PGM2ENO1ENO2ENO3PHGDHPSAT1PSPHSHMT1SHMT2SDSSDSLPKLRLDHALDHBLDHDLDHCPKMHIF1APKM2PDGFRBKDRBHLHE41CDH13CEP290KSR1PGBD5PLOD2SSPNRAPGEF5ZEB1TOX2Activating mutationInactivating mutationProteasome degradationNucleus


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Von Roemeling CA, Marlow LA, Radisky DC, Rohl A, Larsen HE, Wei J, Sasinowska H, Zhu H, Drake R, Sasinowski M, Tun HW, Copland JA; ''Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration.''; Oncotarget, 2014 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  3. Riazalhosseini Y, Lathrop M; ''Precision medicine from the renal cancer genome.''; Nat Rev Nephrol, 2016 PubMed Europe PMC Scholia
  4. Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, Aras O, Han S, Oyama T, Takeda S, Ray CE, Dong Z, Berge M, Hakimi AA, Monette S, Lekaye CL, Koutcher JA, Leslie CS, Creighton CJ, Weinhold N, Lee W, Tickoo SK, Wang Z, Cheng EH, Hsieh JJ; ''The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma.''; Cell Rep, 2017 PubMed Europe PMC Scholia
  5. Dey N, Das F, Mariappan MM, Mandal CC, Ghosh-Choudhury N, Kasinath BS, Choudhury GG; ''MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  6. Gao X, Wang H, Yang JJ, Liu X, Liu ZR; ''Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.''; Mol Cell, 2012 PubMed Europe PMC Scholia
  7. ''Comprehensive molecular characterization of clear cell renal cell carcinoma.''; Nature, 2013 PubMed Europe PMC Scholia
  8. Demaria M, Poli V; ''PKM2, STAT3 and HIF-1α: The Warburg's vicious circle.''; JAKSTAT, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135127view12:32, 6 August 2024EweitzStandardize case
135126view12:31, 6 August 2024EweitzStandardize case
135125view12:28, 6 August 2024EweitzRefine legend
135124view12:27, 6 August 2024EweitzEconomize layout
127315view23:09, 12 September 2023KhanspersUpdated phospho site
123404view06:42, 23 July 2022EgonwMade four pathways clickable
117168view09:52, 18 May 2021EweitzModified title
111011view23:07, 29 June 2020KhanspersModified description
110874view16:34, 16 June 2020KhanspersModified description
106515view21:04, 5 September 2019KhanspersModified description
105485view05:41, 8 August 2019KhanspersModified description
105457view05:07, 8 August 2019KhanspersModified description
98359view06:12, 24 August 2018EgonwUpdated the MIR21 identifier.
97121view16:25, 30 April 2018Khanspersremoved unused anchor
97120view16:23, 30 April 2018Khanspersmutations
93145view20:21, 31 July 2017KhanspersModified description
93144view20:13, 31 July 2017Khanspersremoved extraneous comments on nodes
93143view20:05, 31 July 2017Khanspersupdated lit refs, updated details of PBRM1-STAT3 interaction
93142view19:00, 31 July 2017Khanspersadded lit refs
93141view18:28, 31 July 2017KhanspersModified title
93140view18:27, 31 July 2017KhanspersModified description
93139view18:12, 31 July 2017Khanspersupdated mutations, added legend, updated interactions
93109view18:39, 28 July 2017AlexanderPicoOntology Term : 'DOID:4451' removed !
93108view18:39, 28 July 2017AlexanderPicoOntology Term : 'renal clear cell carcinoma' added !
93107view18:38, 28 July 2017AlexanderPicoOntology Term : 'kidney proximal convoluted tubule epithelial cell' added !
93106view18:37, 28 July 2017AlexanderPicoOntology Term : 'kidney cell' added !
93105view18:23, 28 July 2017AlexanderPicoTesting new mutation glyphs
93104view18:16, 28 July 2017AlexanderPicoTesting mutation state glyphs
92883view22:30, 13 July 2017AlexanderPicoOntology Term : 'signaling pathway' added !
92882view22:30, 13 July 2017AlexanderPicoOntology Term : 'renal carcinoma' added !
92881view22:29, 13 July 2017AlexanderPicoModified title
92880view22:29, 13 July 2017AlexanderPicoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACACAGeneProductENSG00000278540 (Ensembl)
ACACBGeneProductENSG00000076555 (Ensembl)
ACLYGeneProductENSG00000131473 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
ALDOAGeneProductENSG00000149925 (Ensembl)
ALDOBGeneProductENSG00000136872 (Ensembl)
ALDOCGeneProductENSG00000109107 (Ensembl)
AMPKGeneProduct
AngiogenesisPathwayWP1539 (WikiPathways)
BAP1GeneProductENSG00000163930 (Ensembl) Inactivating mutation
BHLHE41GeneProductENSG00000123095 (Ensembl)
CAMK1GeneProductENSG00000134072 (Ensembl)
CBPGeneProductENSG00000005339 (Ensembl)
CDH13GeneProductENSG00000140945 (Ensembl)
CEP290GeneProductENSG00000198707 (Ensembl)
Cell proliferationPathway
DEPTORGeneProductENSG00000155792 (Ensembl)
EFCAB3GeneProductENSG00000172421 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ENO1GeneProductENSG00000074800 (Ensembl)
ENO2GeneProductENSG00000111674 (Ensembl)
ENO3GeneProductENSG00000108515 (Ensembl)
ENPP3GeneProductENSG00000154269 (Ensembl)
FASNGeneProductENSG00000169710 (Ensembl)
FLT1GeneProductENSG00000102755 (Ensembl)
Fatty Acid SynthesisPathwayWP357 (WikiPathways)
GAPDHGeneProductENSG00000111640 (Ensembl)
GLUT1GeneProductENSG00000117394 (Ensembl)
GPIGeneProductENSG00000105220 (Ensembl)
GRB10GeneProductENSG00000106070 (Ensembl)
GlycolysisPathwayWP534 (WikiPathways)
H2GeneProduct
H3GeneProduct
HIF1AGeneProductENSG00000100644 (Ensembl)
HIF1BGeneProductENSG00000143437 (Ensembl)
HK1GeneProductENSG00000156515 (Ensembl)
HK2GeneProductENSG00000159399 (Ensembl)
HK3GeneProductENSG00000160883 (Ensembl)
KCNJ2GeneProductENSG00000123700 (Ensembl)
KDM5CGeneProductENSG00000126012 (Ensembl) Inactivating mutation
KDRGeneProductENSG00000128052 (Ensembl)
KSR1GeneProductENSG00000141068 (Ensembl)
LDHAGeneProductENSG00000134333 (Ensembl)
LDHBGeneProductENSG00000111716 (Ensembl)
LDHCGeneProductENSG00000166796 (Ensembl)
LDHDGeneProductENSG00000166816 (Ensembl)
MDH1GeneProductENSG00000014641 (Ensembl)
ME1GeneProductENSG00000065833 (Ensembl)
MIR21RnaENSG00000199004 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
PBRM1GeneProductENSG00000163939 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PFKLGeneProductENSG00000141959 (Ensembl)
PFKMGeneProductENSG00000152556 (Ensembl)
PFKPGeneProductENSG00000067057 (Ensembl)
PGBD5GeneProductENSG00000177614 (Ensembl)
PGK1GeneProductENSG00000102144 (Ensembl)
PGK2GeneProductENSG00000170950 (Ensembl)
PGM1GeneProductENSG00000079739 (Ensembl)
PGM2GeneProductENSG00000169299 (Ensembl)
PHGDHGeneProductENSG00000092621 (Ensembl)
PI3KGeneProduct
PKLRGeneProductENSG00000143627 (Ensembl)
PKM2GeneProductENSG00000067225 (Ensembl)
PKMGeneProductENSG00000067225 (Ensembl)
PLOD2GeneProductENSG00000152952 (Ensembl)
PSAT1GeneProductENSG00000135069 (Ensembl)
PSPHGeneProductENSG00000146733 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
Protein TranslationPathwayWP107 (WikiPathways)
RAPGEF5GeneProductENSG00000136237 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RTKsGeneProduct
SDSGeneProductENSG00000135094 (Ensembl)
SDSLGeneProductENSG00000139410 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl) Inactivating mutation
SHMT1GeneProductENSG00000176974 (Ensembl)
SHMT2GeneProductENSG00000182199 (Ensembl)
SQSTM1GeneProductENSG00000161011 (Ensembl)
SSPNGeneProductENSG00000123096 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TOX2GeneProductENSG00000124191 (Ensembl)
TPI1GeneProductENSG00000111669 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
VHLGeneProductENSG00000134086 (Ensembl)
ZEB1GeneProductENSG00000148516 (Ensembl)
glucoseMetaboliteCHEBI:17234 (ChEBI)
p300GeneProductENSG00000100393 (Ensembl)

Annotated Interactions

No annotated interactions

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