tRNA aminoacylation (Homo sapiens)

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1, 10, 29, 32, 38...453027311218537191221624356, 8242641914, 214418312515, 20, 282777, 1122, 23, 364423433173cytosolmitochondrial matrixAMPL-TyrATPtRNA(Asn)MARS ATPL-SerPPiRARS PPitRNA(Ala)L-HisLARS AIMP2 FARSA LARS L-TrpAMPtRNA(Phe)Ala-tRNA(Ala)Phe-tRNA(Phe)AIMP2 Asp-tRNA(Asp)tRNA(Phe)Thr-tRNA(Thr)Ile-tRNA(Ile)AIMP2 QARS YARS PPiIARS ATPEEF1E1 YARS2 His-tRNA(His)EPRS PPiATPIARS2L-HisAMPATPPPitRNA(Pro)RARS WARS dimerNARSTrp-tRNA(Trp)EPRS PPiAMPVal-tRNA(Val)KARS ATPRARS PPitRNA(Cys)aminoacyl-tRNAsynthetasemultienzyme complextRNA(Thr)MARS MARS tRNA(His)AARS2KARS Leu-tRNA(Leu)EEF1E1 L-CysPPiL-PhetRNA(Leu)EPRS Lys-tRNA(Lys)Gly-tRNA(Gly)YARS dimerAMPL-AspCys-tRNA(Cys)ATPAMPPPiaminoacyl-tRNAsynthetasemultienzyme complexLARS SARS dimerL-AspAIMP1(1-312) tRNA(Val)L-MetPPiL-ThrATPtRNA(Glu)Asp-tRNA(Asp)IARS tRNA(Trp)aminoacyl-tRNAsynthetasemultienzyme complexCARS2(1-?)KARS CARS dimerATPATPAMPFARS2(1-?)tRNA(Tyr)L-SerEPRS tRNA(Gln)ATPDARS DARS AMPATPAMPTyr-tRNA(Tyr)LARS L-AsnQARS ATPL-ValtRNA(Arg)H2OMARS PPA2 ATPPPiAMPAMPCARS DARS2 dimerPro-tRNA(Pro)PiKARS IARS Asn-tRNA(Asn)L-AlaAMPAMPaminoacyl-tRNAsynthetasemultienzyme complexRARS AMPtRNA(Leu)ATPAIMP1(1-312) AIMP1(1-312) PPitRNA(Gly)ATPL-LystRNA(Val)PPA2 dimerGly-tRNA(Gly)FARSB EARS2MARS2EEF1E1 PPiGlyAMPGln-tRNA(Gln)Asn-tRNA(Asn)tRNA(Arg)AMPtRNA(Asp)AIMP2 EPRS Glu-tRNA(Glu)tRNA(Gly)His-tRNA(His)QARS WARS2PPiTARS2(1-?)KARS tRNA(Met)Trp-tRNA(Trp)RARS KARS AIMP1(1-312) ATPATPL-PheGARS dimerAla-tRNA(Ala)AMPtRNA(Gln)QARS ATPGARS(55-739) L-LeuPPiArg-tRNA(Arg)ATPAMPPPiIARS EPRS AIMP2 QARS Ser-tRNA(Ser)L-GluEPRS EEF1E1 EEF1E1 L-AsnAMPPPiDARS L-Glnaminoacyl-tRNAsynthetasemultienzyme complexATPPPiAIMP2 RARS tRNA(Ser)AIMP2 KARS dimeraminoacyl-tRNAsynthetasemultienzyme complexGARS ATPtRNA(His)tRNA(Pro)PPiATPATPaminoacyl-tRNAsynthetasemultienzyme complexAMPMARS PPiAMPRARS2VARSPPiMg2+Cys-tRNA(Cys)Ile-tRNA(Ile)ATPLys-tRNA(Lys)PPA1 AIMP1(1-312) ATPAMPGln-tRNA(Gln)QARS ATPAMPAMPtRNA(Trp)L-MetAMPtRNA(Thr)MARS Met-tRNA(Met)L-IleEPRS L-ArgL-TyrPPiATPPPiAMPEEF1E1 Val-tRNA(Val)ATPATPKARS tRNA(Ile)HARSaminoacyl-tRNAsynthetasemultienzyme complexDARS AMPFARS A2B2 tetramerAMPGluL-IleMet-tRNA(Met)IARS AMPEEF1E1 SARS IARS AIMP1(1-312) GlyQARS SARS2 dimerTARS EEF1E1 ATPPPiPPiGlu-tRNA(Glu)AMPH2OPPiGARS dimerPPiAIMP2 AMPRARS PPA1 dimertRNA(Cys)DARS AMPMARS KARS AIMP1(1-312) LARS PPiAIMP2 AMPATPL-ArgTARS dimerPPiDARS2 HARS2L-ValLARS L-ProAMPEEF1E1 PPiPPiThr-tRNA(Thr)PPiDARS KARS ATPPPiPro-tRNA(Pro)DARS ATPAMPATPL-TrpQARS PiNARS2Tyr-tRNA(Tyr)MARS L-LeuATPPPiIARS ATPSer-tRNA(Ser)tRNA(Tyr)ATPAMPPARS2PPiPhe-tRNA(Phe)tRNA(Asn)tRNA(Met)EPRS tRNA(Ala)PPiAARStRNA(Lys)AIMP1(1-312) AMPPPiAMPDARS LARS IARS LARS tRNA(Lys)LARS LARS2(1-?)L-ThrATPQARSSARS2 QARS AIMP1(1-312) tRNA(Glu)L-LysPPitRNA(Ser)PPiDARS L-AlaPPitRNA(Asp)PPiAMPMg2+Leu-tRNA(Leu)KARS Arg-tRNA(Arg)PPiATPRARS MARS L-CystRNA(Ile)YARS2 dimerAMPWARS L-ProRARS VARS2IARS L-Glnaminoacyl-tRNAsynthetasemultienzyme complex13131323, 36131313131313


Description

tRNA synthetases catalyze the ligation of tRNAs to their cognate amino acids in an ATP-dependent manner. The reaction proceeds in two steps. First, amino acid and ATP form an aminoacyl adenylate molecule, releasing pyrophosphate. The aminoacyl adenylate remains associated with the synthetase enzyme where, in the second step it reacts with tRNA to form aminoacyl tRNA and AMP. The rapid hydrolysis of pyrophosphate makes these reactions essentially irreversible under physiological conditions (Fersht and Kaethner 1976a). Specificity of the tRNA charging reactions is achieved both by specific recognition of amino acid and tRNA substrates by the synthetase, and by an editing process in which incorrect aminoacyl adenylate molecules (e.g., valyl adenylate associated with isoleucyl tRNA synthetase) are hydrolyzed rather than conjugated to tRNAs in the second step of the reaction (Baldwin and Berg 1966a,b; Fersht and Kaethner 1976b). The tRNA synthetases can be divided into two structural classes based on conserved amino acid sequence features (Burnbaum and Schimmel 1991).

A single synthetase mediates the charging of all of the tRNA species specific for any one amino acid but, with three exceptions, glycine, lysine, and glutamine, the synthetase that catalyzes aminoacylation of mitochondrial tRNAs is encoded by a different gene than the one that acts on mitochondrial tRNAs. Both mitochondrial and cytosolic tRNA synthetase enzymes are encoded by genes in the nuclear genome.<p>A number of tRNA synthetases are known to have functions distinct from tRNA charging (reviewed by Park et al. 2005). Additionally, mutations in several of the tRNA synthetases, often affecting protein domains that are dispensable in vitro for aminoacyl tRNA synthesis, are associated with a diverse array of neurological and other diseases (Antonellis and Green 2008; Park et al. 2008). These findings raise interest into the role of these enzymes in human development and disease.<p> View original pathway at:Reactome.</div>

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 379724
Reactome-version 
Reactome version: 61
Reactome Author 
Reactome Author: D'Eustachio, Peter

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116664view12:24, 9 May 2021EweitzModified title
114669view16:14, 25 January 2021ReactomeTeamReactome version 75
113116view11:18, 2 November 2020ReactomeTeamReactome version 74
112350view15:27, 9 October 2020ReactomeTeamReactome version 73
101251view11:14, 1 November 2018ReactomeTeamreactome version 66
100790view20:42, 31 October 2018ReactomeTeamreactome version 65
100332view19:19, 31 October 2018ReactomeTeamreactome version 64
99877view16:02, 31 October 2018ReactomeTeamreactome version 63
99434view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93779view13:35, 16 August 2017ReactomeTeamreactome version 61
93309view11:20, 9 August 2017ReactomeTeamreactome version 61
86391view09:17, 11 July 2016ReactomeTeamreactome version 56
83310view10:45, 18 November 2015ReactomeTeamVersion54
81449view12:59, 21 August 2015ReactomeTeamVersion53
76923view08:19, 17 July 2014ReactomeTeamFixed remaining interactions
76628view12:00, 16 July 2014ReactomeTeamFixed remaining interactions
75959view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75661view10:56, 10 June 2014ReactomeTeamReactome 48 Update
75016view13:53, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74660view08:43, 30 April 2014ReactomeTeamReactome46
74093view12:42, 29 March 2014EgonwFixed the Uniprot-TrEMBL data sources.
45057view19:53, 6 October 2011KhanspersOntology Term : 'translation pathway' added !
42153view22:00, 4 March 2011MaintBotAutomatic update
39964view05:58, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AARS2ProteinQ5JTZ9 (Uniprot-TrEMBL)
AARSProteinP49588 (Uniprot-TrEMBL)
AIMP1(1-312) ProteinQ12904 (Uniprot-TrEMBL)
AIMP2 ProteinQ13155 (Uniprot-TrEMBL)
AMPMetaboliteCHEBI:16027 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ala-tRNA(Ala)R-HSA-379700 (Reactome)
Ala-tRNA(Ala)R-HSA-379730 (Reactome)
Arg-tRNA(Arg)R-HSA-379708 (Reactome)
Arg-tRNA(Arg)R-HSA-379720 (Reactome)
Asn-tRNA(Asn)R-HSA-379718 (Reactome)
Asn-tRNA(Asn)R-HSA-379728 (Reactome)
Asp-tRNA(Asp)R-HSA-379698 (Reactome)
Asp-tRNA(Asp)R-HSA-379707 (Reactome)
CARS ProteinP49589 (Uniprot-TrEMBL)
CARS dimerComplexR-HSA-379858 (Reactome)
CARS2(1-?)ProteinQ9HA77 (Uniprot-TrEMBL)
Cys-tRNA(Cys)R-HSA-379713 (Reactome)
Cys-tRNA(Cys)R-HSA-379719 (Reactome)
DARS ProteinP14868 (Uniprot-TrEMBL)
DARS2 ProteinQ6PI48 (Uniprot-TrEMBL)
DARS2 dimerComplexR-HSA-379573 (Reactome)
EARS2ProteinQ5JPH6 (Uniprot-TrEMBL)
EEF1E1 ProteinO43324 (Uniprot-TrEMBL)
EPRS ProteinP07814 (Uniprot-TrEMBL)
FARS A2B2 tetramerComplexR-HSA-379637 (Reactome)
FARS2(1-?)ProteinO95363 (Uniprot-TrEMBL)
FARSA ProteinQ9Y285 (Uniprot-TrEMBL)
FARSB ProteinQ9NSD9 (Uniprot-TrEMBL)
GARS ProteinP41250 (Uniprot-TrEMBL)
GARS dimerComplexR-HSA-379593 (Reactome)
GARS dimerComplexR-HSA-379600 (Reactome)
GARS(55-739) ProteinP41250 (Uniprot-TrEMBL)
Gln-tRNA(Gln)R-HSA-379753 (Reactome)
Gln-tRNA(Gln)R-HSA-379772 (Reactome)
Glu-tRNA(Glu)R-HSA-379744 (Reactome)
Glu-tRNA(Glu)R-HSA-379751 (Reactome)
GluMetaboliteCHEBI:29985 (ChEBI)
Gly-tRNA(Gly)R-HSA-379781 (Reactome)
Gly-tRNA(Gly)R-HSA-379784 (Reactome)
GlyMetaboliteCHEBI:57305 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HARS2ProteinP49590 (Uniprot-TrEMBL)
HARSProteinP12081 (Uniprot-TrEMBL)
His-tRNA(His)R-HSA-379764 (Reactome)
His-tRNA(His)R-HSA-379786 (Reactome)
IARS ProteinP41252 (Uniprot-TrEMBL)
IARS2ProteinQ9NSE4 (Uniprot-TrEMBL)
Ile-tRNA(Ile)R-HSA-379769 (Reactome)
Ile-tRNA(Ile)R-HSA-379787 (Reactome)
KARS ProteinQ15046 (Uniprot-TrEMBL)
KARS dimerComplexR-HSA-379687 (Reactome)
L-AlaMetaboliteCHEBI:57972 (ChEBI)
L-ArgMetaboliteCHEBI:32682 (ChEBI)
L-AsnMetaboliteCHEBI:58048 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-CysMetaboliteCHEBI:35235 (ChEBI)
L-GlnMetaboliteCHEBI:58359 (ChEBI)
L-GluMetaboliteCHEBI:29985 (ChEBI)
L-HisMetaboliteCHEBI:32513 (ChEBI)
L-IleMetaboliteCHEBI:58045 (ChEBI)
L-LeuMetaboliteCHEBI:57427 (ChEBI)
L-LysMetaboliteCHEBI:32551 (ChEBI)
L-MetMetaboliteCHEBI:57844 (ChEBI)
L-PheMetaboliteCHEBI:58095 (ChEBI)
L-ProMetaboliteCHEBI:60039 (ChEBI)
L-SerMetaboliteCHEBI:33384 (ChEBI)
L-ThrMetaboliteCHEBI:57926 (ChEBI)
L-TrpMetaboliteCHEBI:57912 (ChEBI)
L-TyrMetaboliteCHEBI:58315 (ChEBI)
L-ValMetaboliteCHEBI:57762 (ChEBI)
LARS ProteinQ9P2J5 (Uniprot-TrEMBL)
LARS2(1-?)ProteinQ15031 (Uniprot-TrEMBL)
Leu-tRNA(Leu)R-HSA-379757 (Reactome)
Leu-tRNA(Leu)R-HSA-379773 (Reactome)
Lys-tRNA(Lys)R-HSA-379736 (Reactome)
Lys-tRNA(Lys)R-HSA-379795 (Reactome)
MARS ProteinP56192 (Uniprot-TrEMBL)
MARS2ProteinQ96GW9 (Uniprot-TrEMBL)
Met-tRNA(Met)R-HSA-379780 (Reactome)
Met-tRNA(Met)R-HSA-379794 (Reactome)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NARS2ProteinQ96I59 (Uniprot-TrEMBL)
NARSProteinO43776 (Uniprot-TrEMBL)
PARS2ProteinQ7L3T8 (Uniprot-TrEMBL)
PPA1 ProteinQ15181 (Uniprot-TrEMBL)
PPA1 dimerComplexR-HSA-71726 (Reactome)
PPA2 ProteinQ9H2U2 (Uniprot-TrEMBL)
PPA2 dimerComplexR-HSA-449923 (Reactome)
PPiMetaboliteCHEBI:29888 (ChEBI)
Phe-tRNA(Phe)R-HSA-379789 (Reactome)
Phe-tRNA(Phe)R-HSA-379792 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
Pro-tRNA(Pro)R-HSA-379745 (Reactome)
Pro-tRNA(Pro)R-HSA-379746 (Reactome)
QARS ProteinP47897 (Uniprot-TrEMBL)
QARSProteinP47897 (Uniprot-TrEMBL)
RARS ProteinP54136 (Uniprot-TrEMBL)
RARS2ProteinQ5T160 (Uniprot-TrEMBL)
SARS ProteinP49591 (Uniprot-TrEMBL)
SARS dimerComplexR-HSA-379557 (Reactome)
SARS2 ProteinQ9NP81 (Uniprot-TrEMBL)
SARS2 dimerComplexR-HSA-379672 (Reactome)
Ser-tRNA(Ser)R-HSA-379738 (Reactome)
Ser-tRNA(Ser)R-HSA-379777 (Reactome)
TARS ProteinP26639 (Uniprot-TrEMBL)
TARS dimerComplexR-HSA-379624 (Reactome)
TARS2(1-?)ProteinQ9BW92 (Uniprot-TrEMBL)
Thr-tRNA(Thr)R-HSA-379779 (Reactome)
Thr-tRNA(Thr)R-HSA-379783 (Reactome)
Trp-tRNA(Trp)R-HSA-379759 (Reactome)
Trp-tRNA(Trp)R-HSA-379765 (Reactome)
Tyr-tRNA(Tyr)R-HSA-379755 (Reactome)
Tyr-tRNA(Tyr)R-HSA-379785 (Reactome)
VARS2ProteinQ5ST30 (Uniprot-TrEMBL)
VARSProteinP26640 (Uniprot-TrEMBL)
Val-tRNA(Val)R-HSA-379782 (Reactome)
Val-tRNA(Val)R-HSA-379790 (Reactome)
WARS ProteinP23381 (Uniprot-TrEMBL)
WARS dimerComplexR-HSA-379684 (Reactome)
WARS2ProteinQ9UGM6 (Uniprot-TrEMBL)
YARS ProteinP54577 (Uniprot-TrEMBL)
YARS dimerComplexR-HSA-379566 (Reactome)
YARS2 ProteinQ9Y2Z4 (Uniprot-TrEMBL)
YARS2 dimerComplexR-HSA-379656 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
ComplexR-HSA-379688 (Reactome)
tRNA(Ala)R-HSA-379729 (Reactome)
tRNA(Ala)R-HSA-379731 (Reactome)
tRNA(Arg)R-HSA-379704 (Reactome)
tRNA(Arg)R-HSA-379727 (Reactome)
tRNA(Asn)R-HSA-379699 (Reactome)
tRNA(Asn)R-HSA-379722 (Reactome)
tRNA(Asp)R-HSA-379711 (Reactome)
tRNA(Asp)R-HSA-379715 (Reactome)
tRNA(Cys)R-HSA-379714 (Reactome)
tRNA(Cys)R-HSA-379725 (Reactome)
tRNA(Gln)R-HSA-379740 (Reactome)
tRNA(Gln)R-HSA-379748 (Reactome)
tRNA(Glu)R-HSA-379754 (Reactome)
tRNA(Glu)R-HSA-379778 (Reactome)
tRNA(Gly)R-HSA-379766 (Reactome)
tRNA(Gly)R-HSA-379770 (Reactome)
tRNA(His)R-HSA-379752 (Reactome)
tRNA(His)R-HSA-379758 (Reactome)
tRNA(Ile)R-HSA-379739 (Reactome)
tRNA(Ile)R-HSA-379750 (Reactome)
tRNA(Leu)R-HSA-379771 (Reactome)
tRNA(Leu)R-HSA-379788 (Reactome)
tRNA(Lys)R-HSA-379747 (Reactome)
tRNA(Lys)R-HSA-379776 (Reactome)
tRNA(Met)R-HSA-379741 (Reactome)
tRNA(Met)R-HSA-379742 (Reactome)
tRNA(Phe)R-HSA-379760 (Reactome)
tRNA(Phe)R-HSA-379767 (Reactome)
tRNA(Pro)R-HSA-379768 (Reactome)
tRNA(Pro)R-HSA-379775 (Reactome)
tRNA(Ser)R-HSA-379761 (Reactome)
tRNA(Ser)R-HSA-379762 (Reactome)
tRNA(Thr)R-HSA-379749 (Reactome)
tRNA(Thr)R-HSA-379791 (Reactome)
tRNA(Trp)R-HSA-379763 (Reactome)
tRNA(Trp)R-HSA-379774 (Reactome)
tRNA(Tyr)R-HSA-379743 (Reactome)
tRNA(Tyr)R-HSA-379756 (Reactome)
tRNA(Val)R-HSA-379735 (Reactome)
tRNA(Val)R-HSA-379793 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
AARS2mim-catalysisR-HSA-380177 (Reactome)
AARSmim-catalysisR-HSA-379864 (Reactome)
AMPArrowR-HSA-379844 (Reactome)
AMPArrowR-HSA-379848 (Reactome)
AMPArrowR-HSA-379861 (Reactome)
AMPArrowR-HSA-379864 (Reactome)
AMPArrowR-HSA-379865 (Reactome)
AMPArrowR-HSA-379867 (Reactome)
AMPArrowR-HSA-379887 (Reactome)
AMPArrowR-HSA-379893 (Reactome)
AMPArrowR-HSA-379974 (Reactome)
AMPArrowR-HSA-379977 (Reactome)
AMPArrowR-HSA-379980 (Reactome)
AMPArrowR-HSA-379982 (Reactome)
AMPArrowR-HSA-379992 (Reactome)
AMPArrowR-HSA-379993 (Reactome)
AMPArrowR-HSA-379994 (Reactome)
AMPArrowR-HSA-379996 (Reactome)
AMPArrowR-HSA-380002 (Reactome)
AMPArrowR-HSA-380008 (Reactome)
AMPArrowR-HSA-380042 (Reactome)
AMPArrowR-HSA-380048 (Reactome)
AMPArrowR-HSA-380157 (Reactome)
AMPArrowR-HSA-380158 (Reactome)
AMPArrowR-HSA-380170 (Reactome)
AMPArrowR-HSA-380176 (Reactome)
AMPArrowR-HSA-380177 (Reactome)
AMPArrowR-HSA-380198 (Reactome)
AMPArrowR-HSA-380199 (Reactome)
AMPArrowR-HSA-380200 (Reactome)
AMPArrowR-HSA-380201 (Reactome)
AMPArrowR-HSA-380203 (Reactome)
AMPArrowR-HSA-380216 (Reactome)
AMPArrowR-HSA-380222 (Reactome)
AMPArrowR-HSA-380224 (Reactome)
AMPArrowR-HSA-380227 (Reactome)
AMPArrowR-HSA-380229 (Reactome)
AMPArrowR-HSA-380233 (Reactome)
AMPArrowR-HSA-380234 (Reactome)
AMPArrowR-HSA-380239 (Reactome)
AMPArrowR-HSA-380240 (Reactome)
AMPArrowR-HSA-380241 (Reactome)
ATPR-HSA-379844 (Reactome)
ATPR-HSA-379848 (Reactome)
ATPR-HSA-379861 (Reactome)
ATPR-HSA-379864 (Reactome)
ATPR-HSA-379865 (Reactome)
ATPR-HSA-379867 (Reactome)
ATPR-HSA-379887 (Reactome)
ATPR-HSA-379893 (Reactome)
ATPR-HSA-379974 (Reactome)
ATPR-HSA-379977 (Reactome)
ATPR-HSA-379980 (Reactome)
ATPR-HSA-379982 (Reactome)
ATPR-HSA-379992 (Reactome)
ATPR-HSA-379993 (Reactome)
ATPR-HSA-379994 (Reactome)
ATPR-HSA-379996 (Reactome)
ATPR-HSA-380002 (Reactome)
ATPR-HSA-380008 (Reactome)
ATPR-HSA-380042 (Reactome)
ATPR-HSA-380048 (Reactome)
ATPR-HSA-380157 (Reactome)
ATPR-HSA-380158 (Reactome)
ATPR-HSA-380170 (Reactome)
ATPR-HSA-380176 (Reactome)
ATPR-HSA-380177 (Reactome)
ATPR-HSA-380198 (Reactome)
ATPR-HSA-380199 (Reactome)
ATPR-HSA-380200 (Reactome)
ATPR-HSA-380201 (Reactome)
ATPR-HSA-380203 (Reactome)
ATPR-HSA-380216 (Reactome)
ATPR-HSA-380222 (Reactome)
ATPR-HSA-380224 (Reactome)
ATPR-HSA-380227 (Reactome)
ATPR-HSA-380229 (Reactome)
ATPR-HSA-380233 (Reactome)
ATPR-HSA-380234 (Reactome)
ATPR-HSA-380239 (Reactome)
ATPR-HSA-380240 (Reactome)
ATPR-HSA-380241 (Reactome)
Ala-tRNA(Ala)ArrowR-HSA-379864 (Reactome)
Ala-tRNA(Ala)ArrowR-HSA-380177 (Reactome)
Arg-tRNA(Arg)ArrowR-HSA-379993 (Reactome)
Arg-tRNA(Arg)ArrowR-HSA-380224 (Reactome)
Asn-tRNA(Asn)ArrowR-HSA-379996 (Reactome)
Asn-tRNA(Asn)ArrowR-HSA-380227 (Reactome)
Asp-tRNA(Asp)ArrowR-HSA-379867 (Reactome)
Asp-tRNA(Asp)ArrowR-HSA-380229 (Reactome)
CARS dimermim-catalysisR-HSA-379887 (Reactome)
CARS2(1-?)mim-catalysisR-HSA-380158 (Reactome)
Cys-tRNA(Cys)ArrowR-HSA-379887 (Reactome)
Cys-tRNA(Cys)ArrowR-HSA-380158 (Reactome)
DARS2 dimermim-catalysisR-HSA-380229 (Reactome)
EARS2mim-catalysisR-HSA-380216 (Reactome)
FARS A2B2 tetramermim-catalysisR-HSA-379848 (Reactome)
FARS2(1-?)mim-catalysisR-HSA-380203 (Reactome)
GARS dimermim-catalysisR-HSA-380048 (Reactome)
GARS dimermim-catalysisR-HSA-380240 (Reactome)
Gln-tRNA(Gln)ArrowR-HSA-379982 (Reactome)
Gln-tRNA(Gln)ArrowR-HSA-380241 (Reactome)
Glu-tRNA(Glu)ArrowR-HSA-379861 (Reactome)
Glu-tRNA(Glu)ArrowR-HSA-380216 (Reactome)
GluR-HSA-380216 (Reactome)
Gly-tRNA(Gly)ArrowR-HSA-380048 (Reactome)
Gly-tRNA(Gly)ArrowR-HSA-380240 (Reactome)
GlyR-HSA-380048 (Reactome)
GlyR-HSA-380240 (Reactome)
H2OR-HSA-449937 (Reactome)
H2OR-HSA-71732 (Reactome)
HARS2mim-catalysisR-HSA-380234 (Reactome)
HARSmim-catalysisR-HSA-379844 (Reactome)
His-tRNA(His)ArrowR-HSA-379844 (Reactome)
His-tRNA(His)ArrowR-HSA-380234 (Reactome)
IARS2mim-catalysisR-HSA-380176 (Reactome)
Ile-tRNA(Ile)ArrowR-HSA-379893 (Reactome)
Ile-tRNA(Ile)ArrowR-HSA-380176 (Reactome)
KARS dimermim-catalysisR-HSA-380233 (Reactome)
L-AlaR-HSA-379864 (Reactome)
L-AlaR-HSA-380177 (Reactome)
L-ArgR-HSA-379993 (Reactome)
L-ArgR-HSA-380224 (Reactome)
L-AsnR-HSA-379996 (Reactome)
L-AsnR-HSA-380227 (Reactome)
L-AspR-HSA-379867 (Reactome)
L-AspR-HSA-380229 (Reactome)
L-CysR-HSA-379887 (Reactome)
L-CysR-HSA-380158 (Reactome)
L-GlnR-HSA-379982 (Reactome)
L-GlnR-HSA-380241 (Reactome)
L-GluR-HSA-379861 (Reactome)
L-HisR-HSA-379844 (Reactome)
L-HisR-HSA-380234 (Reactome)
L-IleR-HSA-379893 (Reactome)
L-IleR-HSA-380176 (Reactome)
L-LeuR-HSA-379974 (Reactome)
L-LeuR-HSA-380200 (Reactome)
L-LysR-HSA-380008 (Reactome)
L-LysR-HSA-380233 (Reactome)
L-MetR-HSA-379994 (Reactome)
L-MetR-HSA-380157 (Reactome)
L-PheR-HSA-379848 (Reactome)
L-PheR-HSA-380203 (Reactome)
L-ProR-HSA-379865 (Reactome)
L-ProR-HSA-380198 (Reactome)
L-SerR-HSA-379992 (Reactome)
L-SerR-HSA-380239 (Reactome)
L-ThrR-HSA-380002 (Reactome)
L-ThrR-HSA-380201 (Reactome)
L-TrpR-HSA-379977 (Reactome)
L-TrpR-HSA-380222 (Reactome)
L-TyrR-HSA-379980 (Reactome)
L-TyrR-HSA-380170 (Reactome)
L-ValR-HSA-380042 (Reactome)
L-ValR-HSA-380199 (Reactome)
LARS2(1-?)mim-catalysisR-HSA-380200 (Reactome)
Leu-tRNA(Leu)ArrowR-HSA-379974 (Reactome)
Leu-tRNA(Leu)ArrowR-HSA-380200 (Reactome)
Lys-tRNA(Lys)ArrowR-HSA-380008 (Reactome)
Lys-tRNA(Lys)ArrowR-HSA-380233 (Reactome)
MARS2mim-catalysisR-HSA-380157 (Reactome)
Met-tRNA(Met)ArrowR-HSA-379994 (Reactome)
Met-tRNA(Met)ArrowR-HSA-380157 (Reactome)
Mg2+ArrowR-HSA-449937 (Reactome)
Mg2+ArrowR-HSA-71732 (Reactome)
NARS2mim-catalysisR-HSA-380227 (Reactome)
NARSmim-catalysisR-HSA-379996 (Reactome)
PARS2mim-catalysisR-HSA-380198 (Reactome)
PPA1 dimermim-catalysisR-HSA-71732 (Reactome)
PPA2 dimermim-catalysisR-HSA-449937 (Reactome)
PPiArrowR-HSA-379844 (Reactome)
PPiArrowR-HSA-379848 (Reactome)
PPiArrowR-HSA-379861 (Reactome)
PPiArrowR-HSA-379864 (Reactome)
PPiArrowR-HSA-379865 (Reactome)
PPiArrowR-HSA-379867 (Reactome)
PPiArrowR-HSA-379887 (Reactome)
PPiArrowR-HSA-379893 (Reactome)
PPiArrowR-HSA-379974 (Reactome)
PPiArrowR-HSA-379977 (Reactome)
PPiArrowR-HSA-379980 (Reactome)
PPiArrowR-HSA-379982 (Reactome)
PPiArrowR-HSA-379992 (Reactome)
PPiArrowR-HSA-379993 (Reactome)
PPiArrowR-HSA-379994 (Reactome)
PPiArrowR-HSA-379996 (Reactome)
PPiArrowR-HSA-380002 (Reactome)
PPiArrowR-HSA-380008 (Reactome)
PPiArrowR-HSA-380042 (Reactome)
PPiArrowR-HSA-380048 (Reactome)
PPiArrowR-HSA-380157 (Reactome)
PPiArrowR-HSA-380158 (Reactome)
PPiArrowR-HSA-380170 (Reactome)
PPiArrowR-HSA-380176 (Reactome)
PPiArrowR-HSA-380177 (Reactome)
PPiArrowR-HSA-380198 (Reactome)
PPiArrowR-HSA-380199 (Reactome)
PPiArrowR-HSA-380200 (Reactome)
PPiArrowR-HSA-380201 (Reactome)
PPiArrowR-HSA-380203 (Reactome)
PPiArrowR-HSA-380216 (Reactome)
PPiArrowR-HSA-380222 (Reactome)
PPiArrowR-HSA-380224 (Reactome)
PPiArrowR-HSA-380227 (Reactome)
PPiArrowR-HSA-380229 (Reactome)
PPiArrowR-HSA-380233 (Reactome)
PPiArrowR-HSA-380234 (Reactome)
PPiArrowR-HSA-380239 (Reactome)
PPiArrowR-HSA-380240 (Reactome)
PPiArrowR-HSA-380241 (Reactome)
PPiR-HSA-449937 (Reactome)
PPiR-HSA-71732 (Reactome)
Phe-tRNA(Phe)ArrowR-HSA-379848 (Reactome)
Phe-tRNA(Phe)ArrowR-HSA-380203 (Reactome)
PiArrowR-HSA-449937 (Reactome)
PiArrowR-HSA-71732 (Reactome)
Pro-tRNA(Pro)ArrowR-HSA-379865 (Reactome)
Pro-tRNA(Pro)ArrowR-HSA-380198 (Reactome)
QARSmim-catalysisR-HSA-380241 (Reactome)
R-HSA-379844 (Reactome) HARS (cytosolic histidyl tRNA synthetase) catalyzes the reaction of histidine, tRNA(His), and ATP to form His-tRNA(His), AMP, and pyrophosphate (Lee et al. 2002).
R-HSA-379848 (Reactome) FARS (cytosolic phenylalanyl tRNA synthetase) catalyzes the reaction of phenylalanine, tRNA(Phe), and ATP to form Phe-tRNA(Phe), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a heterotetramer of two alpha and two beta subunits (Moor et al. 2002).
R-HSA-379861 (Reactome) Multifunctional EPRS (cytosolic glutamyl prolyl tRNA synthetase) catalyzes the reaction of glutamate, tRNA(Glu), and ATP to form Glu tRNA(Glu), AMP, and pyrophosphate. The same enzyme also catalyzes the charging of tRNA(Pro) with proline. The enzyme is found in the cell as a component of the mutienzyme aminoacyl tRNA synthetase complex (Kaiser et al. 1994).
R-HSA-379864 (Reactome) AARS (cytosolic alanyl tRNA synthetase) catalyzes the reaction of alanine, tRNA(ala), and ATP to form Ala tRNA(Ala), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a monomer (Shiba et al. 1995). A mutation in the editing domain of the mouse Aars gene results in misincorporation of non-cognate amino acids into cellular proteins. This is associated with protein misfolding in Purkinje cells and a phenotype consistent with human ataxia (Lee et al. 2006).
R-HSA-379865 (Reactome) Multifunctional EPRS (cytosolic glutamyl-prolyl tRNA synthetase) catalyzes the reaction of proline, tRNA(Pro), and ATP to form Pro-tRNA(Pro), AMP, and pyrophosphate. The same enzyme also catalyzes the charging of tRNA(Glu) with glutamate. The enzyme is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Kaiser et al. 1994).
R-HSA-379867 (Reactome) DARS (cytosolic aspartyl tRNA synthetase) catalyzes the reaction of aspartate, tRNA(Asp), and ATP to form Asp-tRNA(Asp), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Escalante and Yang 1993).
R-HSA-379887 (Reactome) CARS (cytosolic cysteinyl tRNA synthetase) catalyzes the reaction of cysteine, tRNA(cys), and ATP to form Cys-tRNA(Cys), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homomultimer, probably a dimer (Davidson et al. 2001).
R-HSA-379893 (Reactome) IARS (cytosolic aspartyl tRNA synthetase) catalyzes the reaction of isoleucine, tRNA(Ile), and ATP to form Ile-tRNA(Ile), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Shiba et al. 1994).
R-HSA-379974 (Reactome) LARS (cytosolic leucyl tRNA synthetase) catalyzes the reaction of leucine, tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Ling et al. 2005).
R-HSA-379977 (Reactome) WARS (cytosolic tryptophanyl tRNA synthetase) catalyzes the reaction of tryptophan, tRNA(Trp), and ATP to form Trp-tRNA(Trp), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Bange et al. 1992; Rubin et al. 1991; Yu et al. 2004).
R-HSA-379980 (Reactome) YARS (cytosolic tyrosyl tRNA synthetase) catalyzes the reaction of tyrosine, tRNA(Tyr), and ATP to form Tyr tRNA(Tyr), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Yang et al. 2003). Mutations in the YARS gene are associated with dominant-intermediate Charcot-Marie-Tooth disease – a form of peripheral neuropathy characterized by axon and Schwann cell dysfunction (Jordanova et al. 2006).
R-HSA-379982 (Reactome) QARS (cytosolic glutaminyl tRNA synthetase) catalyzes the reaction of glutamine, tRNA(Gln), and ATP to form Gln-tRNA(Gln), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex. The same gene encodes both the cytosolic and mitochondrial QARS enzymes (Lamour et al. 1994).
R-HSA-379992 (Reactome) SARS (cytosolic seryl tRNA synthetase) catalyzes the reaction of serine, tRNA(Ser), and ATP to form Ser-tRNA(Ser), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer (Hartlein and Cusack 1995; Vincent et al. 1997).
R-HSA-379993 (Reactome) RARS (cytosolic arginyl tRNA synthetase) catalyzes the reaction of arginine, tRNA(Arg), and ATP to form Arg-tRNA(Arg), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Ling et al. 2005).
R-HSA-379994 (Reactome) MARS (cytosolic methionyl tRNA synthetase) catalyzes the reaction of methionine, tRNA(Met), and ATP to form Met-tRNA(Met), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Kaminska et al. 2001).
R-HSA-379996 (Reactome) NARS (cytosolic asparaginyl tRNA synthetase) catalyzes the reaction of asparagine, tRNA(Asn), and ATP to form Asn-tRNA(Asn), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Beaulande et al. 1998).
R-HSA-380002 (Reactome) TARS (cytosolic threonyl tRNA synthetase) catalyzes the reaction of threonine, tRNA(Thr), and ATP to form Thr-tRNA(Thr), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer (Pan et al. 1982).
R-HSA-380008 (Reactome) KARS (cytosolic lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).
R-HSA-380042 (Reactome) VARS (cytosolic valyl tRNA synthetase) catalyzes the reaction of valine, tRNA(Val), and ATP to form Val-tRNA(Val), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Vilalta et al. 1993).
R-HSA-380048 (Reactome) GARS (cytosolic glycyl tRNA synthetase) catalyzes the reaction of glycine, tRNA(Gly), and ATP to form Gly tRNA(Gly), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a dimer. Cytosolic and mitochondrial glycyl tRNA synthetase enzymes are both encoded by the same gene; the cytosolic protein lacks an aminoterminal 54 residue sequence found in the mitochondrial protein. Mutations in GARS are associated with Charcot Marie Tooth disease and distal spinal muscular atrophy, two diseases characterized by axonal dysfunction (Antonellis et al. 2006)
R-HSA-380157 (Reactome) MARS2 (mitochondrial methionyl tRNA synthetase) catalyzes the reaction of methionine, mitochondrial tRNA(Met), and ATP to form Met-tRNA(Met), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Spencer et al. 2004).
R-HSA-380158 (Reactome) CARS2 (mitochondrial cysteinyl tRNA synthetase) catalyzes the reaction of cysteine, mitochondrial tRNA(Cys), and ATP to form Cys-tRNA(Cys), AMP, and pyrophosphate. The CARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
R-HSA-380170 (Reactome) YARS2 (mitochondrial tyrosyl tRNA synthetase) catalyzes the reaction of tyrosine, mitochondrial tRNA(Tyr), and ATP to form Tyr-tRNA(Tyr), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Bonnefond et al. 2005).
R-HSA-380176 (Reactome) IARS2 (mitochondrial isoleucyl tRNA synthetase) catalyzes the reaction of isoleucine, mitochondrial tRNA(Ile), and ATP to form Ile-tRNA(Ile), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Degoul et al. 1995).
R-HSA-380177 (Reactome) AARS2 (mitochondrial alanyl tRNA synthetase) catalyzes the reaction of alanine, mitochondrial tRNA(Ala), and ATP to form Ala-tRNA(Ala), AMP, and pyrophosphate. The AARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
R-HSA-380198 (Reactome) PARS2 (mitochondrial prolyl tRNA synthetase) catalyzes the reaction of proline, mitochondrial tRNA(Pro), and ATP to form Pro-tRNA(Pro), AMP, and pyrophosphate. The PARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
R-HSA-380199 (Reactome) VARS2 (mitochondrial valyl tRNA synthetase) catalyzes the reaction of valine, mitochondrial tRNA(val), and ATP to form Val-tRNA(Val), AMP, and pyrophosphate. The VARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
R-HSA-380200 (Reactome) LARS2 (mitochondrial leucyl tRNA synthetase) catalyzes the reaction of leucine, mitochondrial tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Bullard et al. 2000).
R-HSA-380201 (Reactome) TARS2 (mitochondrial threonyl tRNA synthetase) catalyzes the reaction of threonine, mitochondrial tRNA(Thr), and ATP to form Thr-tRNA(Thr), AMP, and pyrophosphate. The TARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
R-HSA-380203 (Reactome) FARS2 (mitochondrial phenylalanyl tRNA synthetase) catalyzes the reaction of phenylalanine, mitochondrial tRNA(Phe), and ATP to form Phe-tRNA(Phe), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a monomer (Bullard et al. 1999).
R-HSA-380216 (Reactome) EARS2 (mitochondrial glutamyl tRNA synthetase) catalyzes the reaction of glutamate, mitochondrial tRNA(Glu), and ATP to form Glu-tRNA(Glu), AMP, and pyrophosphate. The EARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
R-HSA-380222 (Reactome) WARS2 (mitochondrial tryptophanyl tRNA synthetase) catalyzes the reaction of tryptophan, mitochondrial tRNA(Trp), and ATP to form Trp-tRNA(Trp), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Jorgensen et al. 2000).
R-HSA-380224 (Reactome) RARS2 (mitochondrial arginyl tRNA synthetase) catalyzes the reaction of arginine, mitochondrial tRNA(Arg), and ATP to form Arg tRNA(Arg), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase. Homozygosity for RARS2 mutations has been associated with pontocerebellar hypoplasia – a disease characterized by a severe reduction in cerebellum and brainstem size (Edvardson et al. 2007).
R-HSA-380227 (Reactome) NARS2 (mitochondrial asparaginyl tRNA synthetase) catalyzes the reaction of asparagine, mitochondrial tRNA(Asn), and ATP to form Asn-tRNA(Asn), AMP, and pyrophosphate. The NARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
R-HSA-380229 (Reactome) DARS2 (mitochondrial aspartyl tRNA synthetase) catalyzes the reaction of aspartate, mitochondrial tRNA(Asp), and ATP to form Asp tRNA(Asp), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer (Bonnefond et al. 2005). Homozygosity for DARS2 mutations is associated with leukoencephalopathy with brainstem and spinal cord involvement plus lactate elevation (Scheper et al 2007).
R-HSA-380233 (Reactome) KARS (mitochondrial lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).
R-HSA-380234 (Reactome) HARS2 (mitochondrial histidyl tRNA synthetase) catalyzes the reaction of histidine, mitochondrial tRNA(His), and ATP to form His-tRNA(His), AMP, and pyrophosphate. The enzyme is a class II tRNA synthetase (O'Hanlon et al. 1995).
R-HSA-380239 (Reactome) SARS2 (mitochondrial seryl tRNA synthetase) catalyzes the reaction of serine, mitochondrial tRNA(Ser), and ATP to form Ser-tRNA(Ser), AMP, and pyrophosphate. SARS2 is a class II tRNA synthetase inferred from the biochemical properties of its bovine homologue to function as a dimer (Yokogawa et al. 2000).
R-HSA-380240 (Reactome) GARS (mitochondrial glycyl tRNA synthetase) catalyzes the reaction of glycine, tRNA(Gly), and ATP to form Gly-tRNA(Gly), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a dimer. Cytosolic and mitochondrial glycyl tRNA synthetase enzymes are both encoded by the same gene; the cytosolic protein lacks an aminoterminal 54-residue sequence found in the mitochondrial protein. Mutations in GARS are associated with Charcot-Marie-Tooth disease (Antonellis et al. 2007).
R-HSA-380241 (Reactome) QARS (mitochondrial glutaminyl tRNA synthetase) catalyzes the reaction of glutamine, tRNA(Gln), and ATP to form Gln-tRNA(Gln), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase. The same gene encodes both the cytosolic and mitochondrial QARS enzymes (Lamour et al. 1994).
R-HSA-449937 (Reactome) Mitochondrial PPA2 (pyrophosphatase (inorganic) 2) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme requires Mg++ for activity (Curbo et al. 2006). The enzyme is inferred to be a homodimer by analogy to its cytosolic isoform.
R-HSA-71732 (Reactome) Cytosolic PPA1 (pyrophosphatase (inorganic) 1) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme, a homodimer, requires Mg++ for activity (Fisher et al. 1974; Pynes and Younathan 1967; Thuiller et al. 1978).
RARS2mim-catalysisR-HSA-380224 (Reactome)
SARS dimermim-catalysisR-HSA-379992 (Reactome)
SARS2 dimermim-catalysisR-HSA-380239 (Reactome)
Ser-tRNA(Ser)ArrowR-HSA-379992 (Reactome)
Ser-tRNA(Ser)ArrowR-HSA-380239 (Reactome)
TARS dimermim-catalysisR-HSA-380002 (Reactome)
TARS2(1-?)mim-catalysisR-HSA-380201 (Reactome)
Thr-tRNA(Thr)ArrowR-HSA-380002 (Reactome)
Thr-tRNA(Thr)ArrowR-HSA-380201 (Reactome)
Trp-tRNA(Trp)ArrowR-HSA-379977 (Reactome)
Trp-tRNA(Trp)ArrowR-HSA-380222 (Reactome)
Tyr-tRNA(Tyr)ArrowR-HSA-379980 (Reactome)
Tyr-tRNA(Tyr)ArrowR-HSA-380170 (Reactome)
VARS2mim-catalysisR-HSA-380199 (Reactome)
VARSmim-catalysisR-HSA-380042 (Reactome)
Val-tRNA(Val)ArrowR-HSA-380042 (Reactome)
Val-tRNA(Val)ArrowR-HSA-380199 (Reactome)
WARS dimermim-catalysisR-HSA-379977 (Reactome)
WARS2mim-catalysisR-HSA-380222 (Reactome)
YARS dimermim-catalysisR-HSA-379980 (Reactome)
YARS2 dimermim-catalysisR-HSA-380170 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-379861 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-379865 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-379867 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-379893 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-379974 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-379982 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-379993 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-379994 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-380008 (Reactome)
tRNA(Ala)R-HSA-379864 (Reactome)
tRNA(Ala)R-HSA-380177 (Reactome)
tRNA(Arg)R-HSA-379993 (Reactome)
tRNA(Arg)R-HSA-380224 (Reactome)
tRNA(Asn)R-HSA-379996 (Reactome)
tRNA(Asn)R-HSA-380227 (Reactome)
tRNA(Asp)R-HSA-379867 (Reactome)
tRNA(Asp)R-HSA-380229 (Reactome)
tRNA(Cys)R-HSA-379887 (Reactome)
tRNA(Cys)R-HSA-380158 (Reactome)
tRNA(Gln)R-HSA-379982 (Reactome)
tRNA(Gln)R-HSA-380241 (Reactome)
tRNA(Glu)R-HSA-379861 (Reactome)
tRNA(Glu)R-HSA-380216 (Reactome)
tRNA(Gly)R-HSA-380048 (Reactome)
tRNA(Gly)R-HSA-380240 (Reactome)
tRNA(His)R-HSA-379844 (Reactome)
tRNA(His)R-HSA-380234 (Reactome)
tRNA(Ile)R-HSA-379893 (Reactome)
tRNA(Ile)R-HSA-380176 (Reactome)
tRNA(Leu)R-HSA-379974 (Reactome)
tRNA(Leu)R-HSA-380200 (Reactome)
tRNA(Lys)R-HSA-380008 (Reactome)
tRNA(Lys)R-HSA-380233 (Reactome)
tRNA(Met)R-HSA-379994 (Reactome)
tRNA(Met)R-HSA-380157 (Reactome)
tRNA(Phe)R-HSA-379848 (Reactome)
tRNA(Phe)R-HSA-380203 (Reactome)
tRNA(Pro)R-HSA-379865 (Reactome)
tRNA(Pro)R-HSA-380198 (Reactome)
tRNA(Ser)R-HSA-379992 (Reactome)
tRNA(Ser)R-HSA-380239 (Reactome)
tRNA(Thr)R-HSA-380002 (Reactome)
tRNA(Thr)R-HSA-380201 (Reactome)
tRNA(Trp)R-HSA-379977 (Reactome)
tRNA(Trp)R-HSA-380222 (Reactome)
tRNA(Tyr)R-HSA-379980 (Reactome)
tRNA(Tyr)R-HSA-380170 (Reactome)
tRNA(Val)R-HSA-380042 (Reactome)
tRNA(Val)R-HSA-380199 (Reactome)

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