Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)

From WikiPathways

Revision as of 08:59, 14 September 2017 by Mkutmon (Talk | contribs)
Jump to: navigation, search
2, 4, 10, 13, 19...11, 15, 21, 23, 363, 6, 9, 10, 14...1, 7, 26, 35, 41...12, 16, 20, 22, 25...3, 25, 383, 30, 375, 17, 18, 39nucleoplasmcytosolRCL1 RPS16 RRP9 RPS26 EXOSC4 RPS9 RPS25 RPS28 21S pre-rRNA:SSUprocessomeRPS2 C1DRPL37A RPSA RPL21 RPS10 RPS4Y1 RPS5 NOB1RPS13 NOL11WBSCR22RPL10L RPS4Y2 NHP2L1 RPL24 RPS29 RPS24 RPL6 WDR18 RPL7 PES1 RPL3 SKIV2L2GNL3 RPS21 XRN2DDX21 EBNA1BP2 RPL14 RPLP0 PELP1 RPS19 32S pre-rRNARPS11 RPP14 NOL11RPS12 IMP4 RRP7A WDR43 BYSL MPHOSPH10 LTV1BOP1 SKIV2L2RPP30 DIS3RPL36AL RPS9 RPS8UTPA complexEXOSC1 RPSA RPL7A RPL32 RPL11 RPS15ARRP9 RPS13 RPL29 FBL FCF1RPL34 RPS3 LAS1L FBL RPS27 BMS1 RPS8 RPS26 PES1 NOB1EXOSC6 RPLP1 RPS7 RCL1 LAS1L RCL1 SENP3 FAU RPL13 RPL5 RPS28 UTP18FTSJ3RPS20 CIRH1A RPS6 SENP3 RPS7RPL13A RPL10 CIRH1A WDR12 WDR12 UTPC complexRPL40 RPS27A(77-156) BOP1 RPS2RIOK1 RPL38 MPHOSPH6RPS14HEATR1 RPL31 RPS27LRPS14 EXOSC10XRN2RPL18A RRP36 TEX10 NOP56 RPS5 EXOSC8 5S rRNA IMP4 EXOSC9 WDR43 RPS27A(77-156) RPL41 RPP38 40S ribosomalcomplexRPS12 18SE pre-rRNA:SSUprocessomeFBL RPS19 EXOSC7 EXOSC10:C1D:MPHOSPH6:SKIV2L2:ExosomeNOP56 RPL26 NOL9 WDR75 32S pre-rRNA MPHOSPH6 FBL RPLP2 RPL35 RPL9 PNO1RPP40 RBM28RPS17 C1D RPS16RPS28RRP1RPS27RPS23 RPS3AEXOSC10 NOL12RPL23 RPL15 TSR1 RPS25 RPS23NOB1 XRN2MPHOSPH10 CSNK1DRPS11LAS1LSKIV2L2RPL36 CSNK1D IMP3 NHP2L1 BMS1 NOP56 47S pre-rRNA:SSUprocessomeRPL26L1 IMP3 RIOK2 SKIV2L2 RPS4X NCLRPP21 28SrRNA:12Spre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoWRPS4X RPS15A EXOSC3 RPS6 RPL22 45S pre-rRNA:SSUprocessome30S pre-rRNA:SSUprocessomeRPS18 RPL39 UTP15 IMP3 RPL3L RPS18 RPS27L PES1 TEX10 RCL1 NOL6 MPHOSPH10 MPHOSPH10 RIOK3NOP58 RPL8 RPS3A UTP15 IMP4 RRP9 28S rRNA NHP2L1 RPS27 RPS2 TSR1RPL18 PNO1 RPS7 RPS21 NIP7RPS15 RPS4Y1 18SE pre-rRNA BOP1WDR18 CSNK1ERPS11 RPL30 GNL3:EBNA1BP2:DDX21:PES1RPL37 RPL39L 18SE pre-40SparticleBYSLRPS3A EXOSC5RPL27A RPS4Y2 EXOSC10RPL28 HEATR1 IMP3 NOP58 RPL17 ERI118SE pre-rRNA BMS1 RPS24RPL12 RPS14 32Spre-rRNA:Rix1:LAS1L:NOL9:SENP3RPS27L RPS3 RPS23 RPP25 EXOSC2 NOL9 RPL4 RPL23A RPS16 UTPA complexRPS13RPL22L1 RPS9RPS528S rRNA FAU PeBoW complexRPL27 RPS20 CSNK1E NOP58 RPS10 18S rRNA 12S pre-rRNA RPS15 RPL19 RPL10A RRP9 RPS24 PELP1 WDR75 NOP56 NOP58 RPL35A 5.8S rRNA RPS29 21S pre-rRNA ISG20L2LTV1 RPS17 RPS8 IMP4 RIOK1NHP2L1 NOL9BMS1 RPS6RPL36A RIOK2EXOSC5 60S ribosomalcomplexRPS15A 4535288, 421, 35, 41, 46, 471, 35, 41, 46, 4773333238, 42232116, 31, 38, 483, 39


Description

In humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleolus (Stanek et al. 2001). The 47S precursor is processed over the course of about 5-8 minutes (Popov et al. 2013) by endoribonucleases and exoribonucleases to yield the 28S rRNA and 5.8S rRNA of the 60S subunit and the 18S rRNA of the 40S subunit (reviewed in Mullineus and Lafontaine 2012, Henras et al. 2015). As the pre-rRNA is being transcribed, a large protein complex, the small subunit (SSU) processome, assembles in the region of the 18S rRNA sequence, forming terminal knobs on the pre-rRNA (reviewed in Phipps et al. 2011, inferred from yeast in Dragon et al. 2002). The SSU processome contains both ribosomal proteins of the small subunit and processing factors which process the pre-rRNA and modify nucleotides. Through addition of subunits the SSU processome appears to be converted into the larger 90S pre-ribosome (inferred from yeast in Grandi et al. 2002). An analogous large subunit processome (LSU) assembles in the region of the 28S rRNA, however the LSU is less well characterized (inferred from yeast in McCann et al. 2015).
Following cleavage of the pre-rRNA within internal transcribed spacer 1 (ITS1), the pre-ribosomal particle separates into a pre-60S subunit and a pre-40S subunit in the nucleolus (reviewed in Hernandez-Verdun et al. 2010, Phipps et al. 2011). The pre-60S and pre-40S ribosomal particles are then exported from the nucleus to the cytoplasm where the processing factors dissociate and recycle back to the nucleus
Nuclease digestions of the 47S pre-rRNA can follow several paths. In the major pathway, the ends of the 47S pre-rRNA are trimmed to yield the 45S pre-rRNA. Digestion at site 2 (also called site 2b in mouse, see Henras et al. 2015 for nomenclature) cleaves the 45S pre-rRNA to yield the 30S pre-rRNA containing the 18S rRNA of the small subunit and the 32S pre-rRNA containing the 5.8S rRNA and the 28S rRNA of the large subunit. The 32S pre-rRNA is digested in the nucleus to yield the 5.8S rRNA and the 28S rRNA while the 30S pre-rRNA is digested in the nucleus to yield the 18SE pre-rRNA which is then processed in the nucleus and cytosol to yield the 18S rRNA. At least 286 human proteins, 74 of which have no yeast homolog, are required for efficient processing of pre-rRNA in the nucleus (Tafforeau et al. 2013) View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 6791226
Reactome-version 
Reactome version: 61
Reactome Author 
Reactome Author: May, Bruce

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Mullineux ST, Lafontaine DL.; ''Mapping the cleavage sites on mammalian pre-rRNAs: where do we stand?''; PubMed Europe PMC Scholia
  2. Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C, Kutay U.; ''CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.''; PubMed Europe PMC Scholia
  3. Sato M, Araki N, Kumeta M, Takeyasu K, Taguchi Y, Asai T, Furukawa K, Horigome T.; ''Interaction, mobility, and phosphorylation of human orthologues of WD repeat-containing components of the yeast SSU processome t-UTP sub-complex.''; PubMed Europe PMC Scholia
  4. Zhou GJ, Zhang Y, Wang J, Guo JH, Ni J, Zhong ZM, Wang LQ, Dang YJ, Dai JF, Yu L.; ''Cloning and characterization of a novel human RNA binding protein gene PNO1.''; PubMed Europe PMC Scholia
  5. Haindl M, Harasim T, Eick D, Muller S.; ''The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.''; PubMed Europe PMC Scholia
  6. Turner AJ, Knox AA, Prieto JL, McStay B, Watkins NJ.; ''A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4.''; PubMed Europe PMC Scholia
  7. Yanagida M, Shimamoto A, Nishikawa K, Furuichi Y, Isobe T, Takahashi N.; ''Isolation and proteomic characterization of the major proteins of the nucleolin-binding ribonucleoprotein complexes.''; PubMed Europe PMC Scholia
  8. Castle CD, Cassimere EK, Denicourt C.; ''LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis.''; PubMed Europe PMC Scholia
  9. Ginisty H, Amalric F, Bouvet P.; ''Nucleolin functions in the first step of ribosomal RNA processing.''; PubMed Europe PMC Scholia
  10. Morello LG, Hesling C, Coltri PP, Castilho BA, Rimokh R, Zanchin NI.; ''The NIP7 protein is required for accurate pre-rRNA processing in human cells.''; PubMed Europe PMC Scholia
  11. Prieto JL, McStay B.; ''Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells.''; PubMed Europe PMC Scholia
  12. Tomecki R, Labno A, Drazkowska K, Cysewski D, Dziembowski A.; ''hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.''; PubMed Europe PMC Scholia
  13. Tafforeau L, Zorbas C, Langhendries JL, Mullineux ST, Stamatopoulou V, Mullier R, Wacheul L, Lafontaine DL.; ''The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors.''; PubMed Europe PMC Scholia
  14. Hölzel M, Orban M, Hochstatter J, Rohrmoser M, Harasim T, Malamoussi A, Kremmer E, Längst G, Eick D.; ''Defects in 18 S or 28 S rRNA processing activate the p53 pathway.''; PubMed Europe PMC Scholia
  15. Grandi P, Rybin V, Bassler J, Petfalski E, Strauss D, Marzioch M, Schäfer T, Kuster B, Tschochner H, Tollervey D, Gavin AC, Hurt E.; ''90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors.''; PubMed Europe PMC Scholia
  16. Rouquette J, Choesmel V, Gleizes PE.; ''Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells.''; PubMed Europe PMC Scholia
  17. Hölzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D.; ''Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation.''; PubMed Europe PMC Scholia
  18. Yoshikawa H, Ishikawa H, Izumikawa K, Miura Y, Hayano T, Isobe T, Simpson RJ, Takahashi N.; ''Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis.''; PubMed Europe PMC Scholia
  19. Popov A, Smirnov E, Kováčik L, Raška O, Hagen G, Stixová L, Raška I.; ''Duration of the first steps of the human rRNA processing.''; PubMed Europe PMC Scholia
  20. Sloan KE, Mattijssen S, Lebaron S, Tollervey D, Pruijn GJ, Watkins NJ.; ''Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing.''; PubMed Europe PMC Scholia
  21. McCann KL, Charette JM, Vincent NG, Baserga SJ.; ''A protein interaction map of the LSU processome.''; PubMed Europe PMC Scholia
  22. Gérus M, Bonnart C, Caizergues-Ferrer M, Henry Y, Henras AK.; ''Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit.''; PubMed Europe PMC Scholia
  23. Zorbas C, Nicolas E, Wacheul L, Huvelle E, Heurgué-Hamard V, Lafontaine DL.; ''The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.''; PubMed Europe PMC Scholia
  24. Stanek D, Koberna K, Pliss A, Malínský J, Masata M, Vecerová J, Risueño MC, Raska I.; ''Non-isotopic mapping of ribosomal RNA synthesis and processing in the nucleolus.''; PubMed Europe PMC Scholia
  25. Wang M, Pestov DG.; ''5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decay.''; PubMed Europe PMC Scholia
  26. Phipps KR, Charette J, Baserga SJ.; ''The small subunit processome in ribosome biogenesis—progress and prospects.''; PubMed Europe PMC Scholia
  27. Hölzel M, Grimm T, Rohrmoser M, Malamoussi A, Harasim T, Gruber-Eber A, Kremmer E, Eick D.; ''The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing.''; PubMed Europe PMC Scholia
  28. Freed EF, Prieto JL, McCann KL, McStay B, Baserga SJ.; ''NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.''; PubMed Europe PMC Scholia
  29. Morello LG, Coltri PP, Quaresma AJ, Simabuco FM, Silva TC, Singh G, Nickerson JA, Oliveira CC, Moore MJ, Zanchin NI.; ''The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing.''; PubMed Europe PMC Scholia
  30. Romanova L, Grand A, Zhang L, Rayner S, Katoku-Kikyo N, Kellner S, Kikyo N.; ''Critical role of nucleostemin in pre-rRNA processing.''; PubMed Europe PMC Scholia
  31. Widmann B, Wandrey F, Badertscher L, Wyler E, Pfannstiel J, Zemp I, Kutay U.; ''The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits.''; PubMed Europe PMC Scholia
  32. Hernandez-Verdun D, Roussel P, Thiry M, Sirri V, Lafontaine DL.; ''The nucleolus: structure/function relationship in RNA metabolism.''; PubMed Europe PMC Scholia
  33. Haag S, Kretschmer J, Bohnsack MT.; ''WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA.''; PubMed Europe PMC Scholia
  34. Preti M, O'Donohue MF, Montel-Lehry N, Bortolin-Cavaillé ML, Choesmel V, Gleizes PE.; ''Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA.''; PubMed Europe PMC Scholia
  35. Pertschy B, Schneider C, Gnädig M, Schäfer T, Tollervey D, Hurt E.; ''RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1.''; PubMed Europe PMC Scholia
  36. Kass S, Sollner-Webb B.; ''The first pre-rRNA-processing event occurs in a large complex: analysis by gel retardation, sedimentation, and UV cross-linking.''; PubMed Europe PMC Scholia
  37. O'Donohue MF, Choesmel V, Faubladier M, Fichant G, Gleizes PE.; ''Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits.''; PubMed Europe PMC Scholia
  38. Carron C, O'Donohue MF, Choesmel V, Faubladier M, Gleizes PE.; ''Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals.''; PubMed Europe PMC Scholia
  39. Heindl K, Martinez J.; ''Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing.''; PubMed Europe PMC Scholia
  40. Tomecki R, Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP, Dziembowski A, Jensen TH.; ''The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.''; PubMed Europe PMC Scholia
  41. Wyler E, Zimmermann M, Widmann B, Gstaiger M, Pfannstiel J, Kutay U, Zemp I.; ''Tandem affinity purification combined with inducible shRNA expression as a tool to study the maturation of macromolecular assemblies.''; PubMed Europe PMC Scholia
  42. Grimm T, Hölzel M, Rohrmoser M, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Eick D.; ''Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex.''; PubMed Europe PMC Scholia
  43. Zemp I, Wild T, O'Donohue MF, Wandrey F, Widmann B, Gleizes PE, Kutay U.; ''Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2.''; PubMed Europe PMC Scholia
  44. Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ.; ''A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.''; PubMed Europe PMC Scholia
  45. Rohrmoser M, Hölzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D.; ''Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit.''; PubMed Europe PMC Scholia
  46. Schilders G, van Dijk E, Pruijn GJ.; ''C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing.''; PubMed Europe PMC Scholia
  47. Henras AK, Plisson-Chastang C, O'Donohue MF, Chakraborty A, Gleizes PE.; ''An overview of pre-ribosomal RNA processing in eukaryotes.''; PubMed Europe PMC Scholia
  48. Couté Y, Kindbeiter K, Belin S, Dieckmann R, Duret L, Bezin L, Sanchez JC, Diaz JJ.; ''ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis.''; PubMed Europe PMC Scholia
  49. Sloan KE, Bohnsack MT, Bohnsack MT, Schneider C, Watkins NJ.; ''The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA.''; PubMed Europe PMC Scholia
  50. Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y, Kremmer E, Rao A, Heissmeyer V.; ''Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114630view16:09, 25 January 2021ReactomeTeamReactome version 75
113078view11:13, 2 November 2020ReactomeTeamReactome version 74
112312view15:23, 9 October 2020ReactomeTeamReactome version 73
101211view11:10, 1 November 2018ReactomeTeamreactome version 66
100749view20:35, 31 October 2018ReactomeTeamreactome version 65
100293view19:12, 31 October 2018ReactomeTeamreactome version 64
99839view15:56, 31 October 2018ReactomeTeamreactome version 63
99396view14:34, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99090view12:39, 31 October 2018ReactomeTeamreactome version 62
94494view08:59, 14 September 2017Mkutmonreactome version 61
86967view13:41, 15 July 2016MkutmonOntology Term : 'RNA processing pathway' added !
86396view09:17, 11 July 2016ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12S pre-rRNA R-HSA-6791201 (Reactome)
18S rRNA ProteinX03205 (EMBL)
18SE pre-40S particleComplexR-HSA-6791531 (Reactome)
18SE pre-rRNA R-HSA-6791204 (Reactome)
18SE pre-rRNA:SSU processomeComplexR-HSA-6791187 (Reactome)
21S pre-rRNA R-HSA-6791194 (Reactome)
21S pre-rRNA:SSU processomeComplexR-HSA-6791199 (Reactome)
28S

rRNA:12S

pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW		ComplexR-HSA-6791568 (Reactome)
28S rRNA ProteinM11167 (EMBL)
30S pre-rRNA:SSU processomeComplexR-HSA-6791185 (Reactome)
32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3ComplexR-HSA-6791562 (Reactome) The PeBoW complex and the Rix1:LAS1L:NOL9:SENP3 complex associate with pre-60S ribosome subunits during maturation and are required for efficient rRNA processing. Note that this complex contains many ribsomal subunit proteins and processing factors but the precise composition is not known.
32S pre-rRNA R-HSA-6791200 (Reactome)
32S pre-rRNAR-HSA-6791200 (Reactome)
40S ribosomal complexComplexR-HSA-72392 (Reactome)
45S pre-rRNA:SSU processomeComplexR-HSA-6791211 (Reactome)
47S pre-rRNA:SSU processomeComplexR-HSA-6791184 (Reactome)
5.8S rRNA ProteinJ01866 (EMBL)
5S rRNA ProteinV00589 (EMBL)
60S ribosomal complexComplexR-HSA-72499 (Reactome)
BMS1 ProteinQ14692 (Uniprot-TrEMBL)
BOP1 ProteinQ14137 (Uniprot-TrEMBL)
BOP1ProteinQ14137 (Uniprot-TrEMBL)
BYSL ProteinQ13895 (Uniprot-TrEMBL)
BYSLProteinQ13895 (Uniprot-TrEMBL)
C1D ProteinQ13901 (Uniprot-TrEMBL)
C1DProteinQ13901 (Uniprot-TrEMBL)
CIRH1A ProteinQ969X6 (Uniprot-TrEMBL)
CSNK1D ProteinP48730 (Uniprot-TrEMBL)
CSNK1DProteinP48730 (Uniprot-TrEMBL)
CSNK1E ProteinP49674 (Uniprot-TrEMBL)
CSNK1EProteinP49674 (Uniprot-TrEMBL)
DDX21 ProteinQ9NR30 (Uniprot-TrEMBL)
DIS3ProteinQ9Y2L1 (Uniprot-TrEMBL)
EBNA1BP2 ProteinQ99848 (Uniprot-TrEMBL)
ERI1ProteinQ8IV48 (Uniprot-TrEMBL)
EXOSC1 ProteinQ9Y3B2 (Uniprot-TrEMBL)
EXOSC10 ProteinQ01780 (Uniprot-TrEMBL)
EXOSC10:C1D:MPHOSPH6:SKIV2L2:ExosomeComplexR-HSA-6791581 (Reactome)
EXOSC10ProteinQ01780 (Uniprot-TrEMBL)
EXOSC2 ProteinQ13868 (Uniprot-TrEMBL)
EXOSC3 ProteinQ9NQT5 (Uniprot-TrEMBL)
EXOSC4 ProteinQ9NPD3 (Uniprot-TrEMBL)
EXOSC5 ProteinQ9NQT4 (Uniprot-TrEMBL)
EXOSC5ProteinQ9NQT4 (Uniprot-TrEMBL)
EXOSC6 ProteinQ5RKV6 (Uniprot-TrEMBL)
EXOSC7 ProteinQ15024 (Uniprot-TrEMBL)
EXOSC8 ProteinQ96B26 (Uniprot-TrEMBL)
EXOSC9 ProteinQ06265 (Uniprot-TrEMBL)
FAU ProteinP62861 (Uniprot-TrEMBL)
FBL ProteinP22087 (Uniprot-TrEMBL)
FCF1ProteinQ9Y324 (Uniprot-TrEMBL)
FTSJ3ProteinQ8IY81 (Uniprot-TrEMBL)
GNL3 ProteinQ9BVP2 (Uniprot-TrEMBL)
GNL3:EBNA1BP2:DDX21:PES1ComplexR-HSA-8869320 (Reactome)
HEATR1 ProteinQ9H583 (Uniprot-TrEMBL)
IMP3 ProteinQ9NV31 (Uniprot-TrEMBL)
IMP4 ProteinQ96G21 (Uniprot-TrEMBL)
ISG20L2ProteinQ9H9L3 (Uniprot-TrEMBL)
LAS1L ProteinQ9Y4W2 (Uniprot-TrEMBL)
LAS1LProteinQ9Y4W2 (Uniprot-TrEMBL)
LTV1 ProteinQ96GA3 (Uniprot-TrEMBL)
LTV1ProteinQ96GA3 (Uniprot-TrEMBL)
MPHOSPH10 ProteinO00566 (Uniprot-TrEMBL)
MPHOSPH6 ProteinQ99547 (Uniprot-TrEMBL)
MPHOSPH6ProteinQ99547 (Uniprot-TrEMBL)
NCLProteinP19338 (Uniprot-TrEMBL)
NHP2L1 ProteinP55769 (Uniprot-TrEMBL)
NIP7ProteinQ9Y221 (Uniprot-TrEMBL)
NOB1 ProteinQ9ULX3 (Uniprot-TrEMBL)
NOB1ProteinQ9ULX3 (Uniprot-TrEMBL)
NOL11ProteinQ9H8H0 (Uniprot-TrEMBL)
NOL12ProteinQ9UGY1 (Uniprot-TrEMBL)
NOL6 ProteinQ9H6R4 (Uniprot-TrEMBL)
NOL9 ProteinQ5SY16 (Uniprot-TrEMBL)
NOL9ProteinQ5SY16 (Uniprot-TrEMBL)
NOP56 ProteinO00567 (Uniprot-TrEMBL)
NOP58 ProteinQ9Y2X3 (Uniprot-TrEMBL)
PELP1 ProteinQ8IZL8 (Uniprot-TrEMBL)
PES1 ProteinO00541 (Uniprot-TrEMBL)
PNO1 ProteinQ9NRX1 (Uniprot-TrEMBL)
PNO1ProteinQ9NRX1 (Uniprot-TrEMBL)
PeBoW complexComplexR-HSA-6791214 (Reactome)
RBM28ProteinQ9NW13 (Uniprot-TrEMBL)
RCL1 ProteinQ9Y2P8 (Uniprot-TrEMBL)
RIOK1 ProteinQ9BRS2 (Uniprot-TrEMBL)
RIOK1ProteinQ9BRS2 (Uniprot-TrEMBL)
RIOK2 ProteinQ9BVS4 (Uniprot-TrEMBL)
RIOK2ProteinQ9BVS4 (Uniprot-TrEMBL)
RIOK3ProteinO14730 (Uniprot-TrEMBL)
RPL10 ProteinP27635 (Uniprot-TrEMBL)
RPL10A ProteinP62906 (Uniprot-TrEMBL)
RPL10L ProteinQ96L21 (Uniprot-TrEMBL)
RPL11 ProteinP62913 (Uniprot-TrEMBL)
RPL12 ProteinP30050 (Uniprot-TrEMBL)
RPL13 ProteinP26373 (Uniprot-TrEMBL)
RPL13A ProteinP40429 (Uniprot-TrEMBL)
RPL14 ProteinP50914 (Uniprot-TrEMBL)
RPL15 ProteinP61313 (Uniprot-TrEMBL)
RPL17 ProteinP18621 (Uniprot-TrEMBL)
RPL18 ProteinQ07020 (Uniprot-TrEMBL)
RPL18A ProteinQ02543 (Uniprot-TrEMBL)
RPL19 ProteinP84098 (Uniprot-TrEMBL)
RPL21 ProteinP46778 (Uniprot-TrEMBL)
RPL22 ProteinP35268 (Uniprot-TrEMBL)
RPL22L1 ProteinQ6P5R6 (Uniprot-TrEMBL)
RPL23 ProteinP62829 (Uniprot-TrEMBL)
RPL23A ProteinP62750 (Uniprot-TrEMBL)
RPL24 ProteinP83731 (Uniprot-TrEMBL)
RPL26 ProteinP61254 (Uniprot-TrEMBL)
RPL26L1 ProteinQ9UNX3 (Uniprot-TrEMBL)
RPL27 ProteinP61353 (Uniprot-TrEMBL)
RPL27A ProteinP46776 (Uniprot-TrEMBL)
RPL28 ProteinP46779 (Uniprot-TrEMBL)
RPL29 ProteinP47914 (Uniprot-TrEMBL)
RPL3 ProteinP39023 (Uniprot-TrEMBL)
RPL30 ProteinP62888 (Uniprot-TrEMBL)
RPL31 ProteinP62899 (Uniprot-TrEMBL)
RPL32 ProteinP62910 (Uniprot-TrEMBL)
RPL34 ProteinP49207 (Uniprot-TrEMBL)
RPL35 ProteinP42766 (Uniprot-TrEMBL)
RPL35A ProteinP18077 (Uniprot-TrEMBL)
RPL36 ProteinQ9Y3U8 (Uniprot-TrEMBL)
RPL36A ProteinP83881 (Uniprot-TrEMBL)
RPL36AL ProteinQ969Q0 (Uniprot-TrEMBL)
RPL37 ProteinP61927 (Uniprot-TrEMBL)
RPL37A ProteinP61513 (Uniprot-TrEMBL)
RPL38 ProteinP63173 (Uniprot-TrEMBL)
RPL39 ProteinP62891 (Uniprot-TrEMBL)
RPL39L ProteinQ96EH5 (Uniprot-TrEMBL)
RPL3L ProteinQ92901 (Uniprot-TrEMBL)
RPL4 ProteinP36578 (Uniprot-TrEMBL)
RPL40 ProteinP62987 (Uniprot-TrEMBL)
RPL41 ProteinP62945 (Uniprot-TrEMBL)
RPL5 ProteinP46777 (Uniprot-TrEMBL)
RPL6 ProteinQ02878 (Uniprot-TrEMBL)
RPL7 ProteinP18124 (Uniprot-TrEMBL)
RPL7A ProteinP62424 (Uniprot-TrEMBL)
RPL8 ProteinP62917 (Uniprot-TrEMBL)
RPL9 ProteinP32969 (Uniprot-TrEMBL)
RPLP0 ProteinP05388 (Uniprot-TrEMBL)
RPLP1 ProteinP05386 (Uniprot-TrEMBL)
RPLP2 ProteinP05387 (Uniprot-TrEMBL)
RPP14 ProteinO95059 (Uniprot-TrEMBL)
RPP21 ProteinQ9H633 (Uniprot-TrEMBL)
RPP25 ProteinQ9BUL9 (Uniprot-TrEMBL)
RPP30 ProteinP78346 (Uniprot-TrEMBL)
RPP38 ProteinP78345 (Uniprot-TrEMBL)
RPP40 ProteinO75818 (Uniprot-TrEMBL)
RPS10 ProteinP46783 (Uniprot-TrEMBL)
RPS11 ProteinP62280 (Uniprot-TrEMBL)
RPS11ProteinP62280 (Uniprot-TrEMBL)
RPS12 ProteinP25398 (Uniprot-TrEMBL)
RPS13 ProteinP62277 (Uniprot-TrEMBL)
RPS13ProteinP62277 (Uniprot-TrEMBL)
RPS14 ProteinP62263 (Uniprot-TrEMBL)
RPS14ProteinP62263 (Uniprot-TrEMBL)
RPS15 ProteinP62841 (Uniprot-TrEMBL)
RPS15A ProteinP62244 (Uniprot-TrEMBL)
RPS15AProteinP62244 (Uniprot-TrEMBL)
RPS16 ProteinP62249 (Uniprot-TrEMBL)
RPS16ProteinP62249 (Uniprot-TrEMBL)
RPS17 ProteinP08708 (Uniprot-TrEMBL)
RPS18 ProteinP62269 (Uniprot-TrEMBL)
RPS19 ProteinP39019 (Uniprot-TrEMBL)
RPS2 ProteinP15880 (Uniprot-TrEMBL)
RPS20 ProteinP60866 (Uniprot-TrEMBL)
RPS21 ProteinP63220 (Uniprot-TrEMBL)
RPS23 ProteinP62266 (Uniprot-TrEMBL)
RPS23ProteinP62266 (Uniprot-TrEMBL)
RPS24 ProteinP62847 (Uniprot-TrEMBL)
RPS24ProteinP62847 (Uniprot-TrEMBL)
RPS25 ProteinP62851 (Uniprot-TrEMBL)
RPS26 ProteinP62854 (Uniprot-TrEMBL)
RPS27 ProteinP42677 (Uniprot-TrEMBL)
RPS27A(77-156) ProteinP62979 (Uniprot-TrEMBL)
RPS27L ProteinQ71UM5 (Uniprot-TrEMBL)
RPS27LProteinQ71UM5 (Uniprot-TrEMBL)
RPS27ProteinP42677 (Uniprot-TrEMBL)
RPS28 ProteinP62857 (Uniprot-TrEMBL)
RPS28ProteinP62857 (Uniprot-TrEMBL)
RPS29 ProteinP62273 (Uniprot-TrEMBL)
RPS2ProteinP15880 (Uniprot-TrEMBL)
RPS3 ProteinP23396 (Uniprot-TrEMBL)
RPS3A ProteinP61247 (Uniprot-TrEMBL)
RPS3AProteinP61247 (Uniprot-TrEMBL)
RPS4X ProteinP62701 (Uniprot-TrEMBL)
RPS4Y1 ProteinP22090 (Uniprot-TrEMBL)
RPS4Y2 ProteinQ8TD47 (Uniprot-TrEMBL)
RPS5 ProteinP46782 (Uniprot-TrEMBL)
RPS5ProteinP46782 (Uniprot-TrEMBL)
RPS6 ProteinP62753 (Uniprot-TrEMBL)
RPS6ProteinP62753 (Uniprot-TrEMBL)
RPS7 ProteinP62081 (Uniprot-TrEMBL)
RPS7ProteinP62081 (Uniprot-TrEMBL)
RPS8 ProteinP62241 (Uniprot-TrEMBL)
RPS8ProteinP62241 (Uniprot-TrEMBL)
RPS9 ProteinP46781 (Uniprot-TrEMBL)
RPS9ProteinP46781 (Uniprot-TrEMBL)
RPSA ProteinP08865 (Uniprot-TrEMBL)
RRP1ProteinP56182 (Uniprot-TrEMBL)
RRP36 ProteinQ96EU6 (Uniprot-TrEMBL)
RRP7A ProteinQ9Y3A4 (Uniprot-TrEMBL)
RRP9 ProteinO43818 (Uniprot-TrEMBL)
SENP3 ProteinQ9H4L4 (Uniprot-TrEMBL)
SKIV2L2 ProteinP42285 (Uniprot-TrEMBL)
SKIV2L2ProteinP42285 (Uniprot-TrEMBL)
TEX10 ProteinQ9NXF1 (Uniprot-TrEMBL)
TSR1 ProteinQ2NL82 (Uniprot-TrEMBL)
TSR1ProteinQ2NL82 (Uniprot-TrEMBL)
U3 snoRNA Protein
UTP15 ProteinQ8TED0 (Uniprot-TrEMBL)
UTP18ProteinQ9Y5J1 (Uniprot-TrEMBL)
UTPA complexComplexR-HSA-6790880 (Reactome)
UTPC complexComplexR-HSA-6790889 (Reactome)
WBSCR22ProteinO43709 (Uniprot-TrEMBL)
WDR12 ProteinQ9GZL7 (Uniprot-TrEMBL)
WDR18 ProteinQ9BV38 (Uniprot-TrEMBL)
WDR43 ProteinQ15061 (Uniprot-TrEMBL)
WDR75 ProteinQ8IWA0 (Uniprot-TrEMBL)
XRN2ProteinQ9H0D6 (Uniprot-TrEMBL)
nascent pre-rRNA transcript Protein

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
18SE pre-40S particleR-HSA-6791223 (Reactome)
18SE pre-rRNA:SSU processomeArrowR-HSA-6791222 (Reactome)
21S pre-rRNA:SSU processomeArrowR-HSA-6791221 (Reactome)
21S pre-rRNA:SSU processomeR-HSA-6791222 (Reactome)
28S

rRNA:12S

pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW		ArrowR-HSA-6791219 (Reactome)
28S

rRNA:12S

pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW		R-HSA-6791218 (Reactome)
30S pre-rRNA:SSU processomeArrowR-HSA-6791228 (Reactome)
30S pre-rRNA:SSU processomeR-HSA-6791221 (Reactome)
32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3R-HSA-6791219 (Reactome)
32S pre-rRNAArrowR-HSA-6791228 (Reactome)
40S ribosomal complexArrowR-HSA-6791223 (Reactome)
45S pre-rRNA:SSU processomeArrowR-HSA-6791227 (Reactome)
45S pre-rRNA:SSU processomeR-HSA-6791228 (Reactome)
47S pre-rRNA:SSU processomeR-HSA-6791227 (Reactome)
60S ribosomal complexArrowR-HSA-6791218 (Reactome)
BOP1ArrowR-HSA-6791228 (Reactome)
BYSLArrowR-HSA-6791223 (Reactome)
C1DArrowR-HSA-6791218 (Reactome)
CSNK1DArrowR-HSA-6791223 (Reactome)
CSNK1Dmim-catalysisR-HSA-6791223 (Reactome)
CSNK1EArrowR-HSA-6791223 (Reactome)
CSNK1Emim-catalysisR-HSA-6791223 (Reactome)
DIS3ArrowR-HSA-6791218 (Reactome)
ERI1mim-catalysisR-HSA-6791218 (Reactome)
EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosomemim-catalysisR-HSA-6791218 (Reactome)
EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosomemim-catalysisR-HSA-6791222 (Reactome)
EXOSC10ArrowR-HSA-6791218 (Reactome)
EXOSC10ArrowR-HSA-6791222 (Reactome)
EXOSC10ArrowR-HSA-6791228 (Reactome)
EXOSC5ArrowR-HSA-6791222 (Reactome)
FCF1ArrowR-HSA-6791221 (Reactome)
FTSJ3ArrowR-HSA-6791221 (Reactome)
GNL3:EBNA1BP2:DDX21:PES1ArrowR-HSA-6791219 (Reactome)
ISG20L2mim-catalysisR-HSA-6791218 (Reactome)
LAS1LArrowR-HSA-6791219 (Reactome)
LTV1ArrowR-HSA-6791223 (Reactome)
MPHOSPH6ArrowR-HSA-6791218 (Reactome)
NCLArrowR-HSA-6791227 (Reactome)
NIP7ArrowR-HSA-6791221 (Reactome)
NOB1ArrowR-HSA-6791223 (Reactome)
NOB1mim-catalysisR-HSA-6791223 (Reactome)
NOL11ArrowR-HSA-6791221 (Reactome)
NOL11ArrowR-HSA-6791227 (Reactome)
NOL12ArrowR-HSA-6791228 (Reactome)
NOL9ArrowR-HSA-6791219 (Reactome)
PNO1ArrowR-HSA-6791223 (Reactome)
PeBoW complexArrowR-HSA-6791219 (Reactome)
R-HSA-6791218 (Reactome) The 12S pre-rRNA is nucleolytically cleaved to yield 5.8S rRNA. C1D, MPHOSPH6 (MPP6), and EXOSC10 (Pm/Scl-100) of the exosome associate and, together with SKIV2L2 (MTR4), are required for 3' processing of mature 5.8S rRNA therefore the exonuclease activity of the exosome seems to be involved (Schilders et al. 2007). Similarly, the DIS3 subunit of the nuclear exosome is required for production of 5.8S rRNA (Tomecki et al. 2010) and the 3'-5' exoribonuclease ISG20L2 (Coute et al. 2008) are also required for production of 5.8S rRNA from 12S pre-rRNA. As inferred from the mouse homolog, the 3'-5' exonuclease ERI1 also plays a role in trimming the 3' end of pre-5.8S rRNA (Ansel et al. 2008).
R-HSA-6791219 (Reactome) Unknown nucleases process the 32S precursor rRNA (pre-rRNA) at site 4, yielding the 28S rRNA and the 12S pre-RNA that will be further processed to the mature 5.8S rRNA. Processing occurs in precursor 60S ribosomal (pre-60S) subunits that contain ribosomal proteins and processing factors. The PES1:BOP1:WDR12 complex (PeBoW complex) associates with pre-60S subunits in both the nucleus and cytosol where it is involved in processing 32S rRNA and recycling pre-60S subunit processing factors. Perturbation of the PeBoW complex prevents processing of the 32S pre-rRNA (Holzel et al. 2005, Grimm et al. 2006, Holzel et al 2007, Rohrmoser et al. 2007). The polynucleotide kinase activity of NOL9, which is associated with pre-60s subunits, is also required for processing of pre-32S rRNA (Heindl and Martinez 2010). LAS1L interacts with PELP1:TEX10:WDR18, NOL9, and SENP3 in pre-60S subunits where it is required for processing of the internal transcribed spacer 2 (ITS2) in pre-32S rRNA (Castle et al. 2012). The PELP1:TEX10:WDR18 complex is the mammalian homolog of the yeast Rix1 complex (Castle et al. 2012). A complex containing GNL3 (Nucleostemin), EBNA1BP2, DDX21, and PES1 is also required for processing 32S rRNA to 28S rRNA (Romanova et al. 2009). Both the Nucleostemin complex and the PeBoW complex both contain PES1 and therefore may be part of a single larger complex.
R-HSA-6791221 (Reactome) An unknown endonuclease cleaves site 1 (also called site A1), removing the remainder of the 5' external transcribed spacer (5' ETS) from 30S pre-rRNA containing the 18S rRNA (Freed et al. 2012, Tomecki et al. 2015). Sixteen proteins of the small ribosomal subunit are required for processing sequences flanking the 18S rRNA in the 30S pre-rRNA (O'Donohue et al. 2010) presumably due to their assembly onto pre-rRNA as processing proceeds. Additionally, FCF1 (hUTP24, part of the SSU processome) is required for cleavage at site 1 (Tomecki et al. 2015) and NOL11 and CIRH1A (Cirhin, part of the UTPA complex) interact and are required for cleavage at site 1 and other sites (A', A0, and 2) (Freed et al. 2012). FTSJ3 and NIP7 interact and are required for processing at sites 1, 2, and A0 (Morello et al. 2011).
R-HSA-6791222 (Reactome) An unknown endonuclease in the nucleolus cleaves at site E (site 2a in mouse) of 21S pre-rRNA, yielding 18SE pre-rRNA (Preti et al. 2013, Sloan et al. 2013). Evidence also indicates that 18SE may also be produced by an exonucleolytic pathway (Carron et al. 2011, Sloan et al. 2013). BYSL (Bystin, ENG1), SKIV2L2 (MTR4), and the exonuclease activity of EXOSC10 (RRP6), all associated with the exosome, are required for formation of 18SE by the exonucleolytic pathway (Sloan et al. 2013). Sequencing indicates that 18SE molecules can have variable ends, presumably due to exonuclease activity (Preti et al. 2013).
R-HSA-6791223 (Reactome) Exonuclease activity of the exosome (Preti et al. 2013) and endonuclease activity of NOB1 (inferred from yeast, Pertschy et al. 2009) process the 3' end of precursor rRNA (pre-rRNA) 18SE to yield mature 18S rRNA. During the processing, pre-rRNA 18SE is bound in the pre-40S ribosome subunit, which contains ribosomal proteins and processing factors such as NOB1 and BYSL. The pre-40S subunit is exported from the nucleus to the cytosol where processing factors are released and recycled back to the nucleus. The kinases RIOK1, RIOK2, CSNK1D and CSNK1E are associated with the pre-40S rRNA subunit in both the nucleus and cytosol and their kinase activity is required for recycling of processing factors back to the nucleus (Zemp et al. 2009, Zemp et al. 2014). RIOK1 and RIOK2 are also required for 18SE processing (Widmann et al. 2012, Zemp et al. 2009). RIOK3 (RIO3) is a cytosolic kinase that associates with the pre-40S ribosomal particle after export from the nucleus and is required for release of processing factors (Baumas et al. 2012).
R-HSA-6791227 (Reactome) Unknown nucleases concomitantly cleave the 47S precursor rRNA (pre-rRNA) at the A' site (also known as the 01 site or the A1 site), the A0 site in the 5' external transcribed spacer (5' ETS), and site 02 (also known as site 6 in mouse) in the 3' ETS (Sloan et al. 2014). Cleavage occurs when the pre-rRNA is complexed with the small subunit processome (SSU processome) complex, a large protein complex that binds the 5' region of the pre-rRNA after transcription commences (Kass and Sollner-Webb 1990, Sloan et al. 2014, inferred from yeast in Dragon et al. 2002). The UTP-A subcomplex of the SSU processome and SKIV2L2 (MTR4) are required for cleavage at the A' site while the UTP-B subcomplex and U3 snoRNP (Sloan et al. 2014) and RRP36 of the UTPC subcomplex of the SSU processome (Gerus et al. 2010) improve efficiency of cleavage. UTP18 is required for cleavage of the 5' ETS (Holzel et al. 2010). Nucleolin (NCL) interacts with the 47S pre-rRNA (Yanagida et al. 2001, inferred from mouse in Ginisty et al. 1998) and is involved in cleavage at the A' site (inferred from mouse in Ginisty et al. 1998) but its association with the SSU processome is transitory (Turner et al. 2009). NOL11, a component of the SSU processome which interacts with UTP4, increases the efficiency of processing at A', but is not strictly required (Freed et al. 2012). XRN2 exonucleolytically degrades the 5' 01 fragment (Sloan et al. 2013, inferred from mouse homologs in Wang and Pestov 2011).
R-HSA-6791228 (Reactome) An unknown endonuclease cleaves at site 2 (also called site 2b in mouse) in the internal transcribed spacer 1 (ITS1) between the 18S rRNA and the 5.8S rRNA in the 45S precursor rRNA (pre-rRNA) while the pre-rRNA is contained in a 90S particle containing ribosomal proteins and assembly factors (Sloan et al. 2013). (The 90S particle is believed to be produced by addition of further subunits to the complex containing the pre-RNA and the small subunit (SSU) processome (inferred from yeast in Grandi et al. 2002).) The products are a 30S pre-rRNA which contains the 18S rRNA and a 32S pre-rRNA containing the 5.8S rRNA and the 28S rRNA. The cleavage splits the 90S particle into a pre-40S particle and a pre-60S particle and is believed to occur while the 5' region of the 45S rRNA is bound by the SSU processome. BOP1 (a subunit of the PeBoW complex), RBM28, NOL12 and RRP1 (NOP52) also participate in the cleavage (Sloan et al. 2013, Yoshikawa et al. 2015). Exonucleases including XRN2 and EXOSC10 (RRP6) of the exosome complex then remove further nucleotides from the end of the ITS (Sloan et al. 2013).
RBM28ArrowR-HSA-6791228 (Reactome)
RIOK1ArrowR-HSA-6791223 (Reactome)
RIOK2ArrowR-HSA-6791223 (Reactome)
RIOK3ArrowR-HSA-6791223 (Reactome)
RIOK3R-HSA-6791223 (Reactome)
RPS11ArrowR-HSA-6791221 (Reactome)
RPS13ArrowR-HSA-6791221 (Reactome)
RPS14ArrowR-HSA-6791221 (Reactome)
RPS15AArrowR-HSA-6791221 (Reactome)
RPS16ArrowR-HSA-6791221 (Reactome)
RPS23ArrowR-HSA-6791221 (Reactome)
RPS24ArrowR-HSA-6791221 (Reactome)
RPS27ArrowR-HSA-6791221 (Reactome)
RPS27LArrowR-HSA-6791221 (Reactome)
RPS28ArrowR-HSA-6791221 (Reactome)
RPS2ArrowR-HSA-6791221 (Reactome)
RPS3AArrowR-HSA-6791221 (Reactome)
RPS5ArrowR-HSA-6791221 (Reactome)
RPS6ArrowR-HSA-6791221 (Reactome)
RPS7ArrowR-HSA-6791221 (Reactome)
RPS8ArrowR-HSA-6791221 (Reactome)
RPS9ArrowR-HSA-6791221 (Reactome)
RRP1ArrowR-HSA-6791228 (Reactome)
SKIV2L2ArrowR-HSA-6791218 (Reactome)
SKIV2L2ArrowR-HSA-6791222 (Reactome)
SKIV2L2ArrowR-HSA-6791227 (Reactome)
TSR1ArrowR-HSA-6791223 (Reactome)
UTP18ArrowR-HSA-6791227 (Reactome)
UTPA complexArrowR-HSA-6791221 (Reactome)
UTPA complexArrowR-HSA-6791227 (Reactome)
UTPC complexArrowR-HSA-6791227 (Reactome)
WBSCR22ArrowR-HSA-6791223 (Reactome)
XRN2ArrowR-HSA-6791228 (Reactome)
XRN2mim-catalysisR-HSA-6791223 (Reactome)
XRN2mim-catalysisR-HSA-6791227 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3797"
Personal tools