Lipid metabolism pathway (Homo sapiens)
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Description
Lipid metabolism is the break down or storage of fats for energy; these fats are obtained from consuming food and absorbing them or they are synthesized by an animal's liver. Lipid metabolism does exist in plants, though the processes differ in some ways when compared to animals. Lipogenesis is the process of synthesizing these fats. Lipid metabolism often begins with hydrolysis, which occurs when a chemical breaks down as a reaction to coming in contact with water. Since lipids (fats) are hydrophobic, hydrolysis in lipid metabolism occurs in the cytoplasm which ends up creating glycerol and fatty acids. Due to the hydrophobic nature of lipids they require special transport proteins known as lipoproteins, which are hydrophilic. Lipoproteins are categorized by their density levels. The varying densities between the types of lipoproteins are characteristic to what type of fats they transport. A number of these lipoproteins are synthesized in the liver, but not all of them originate from this organ.
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Bibliography
- Zhang X, Saarinen AM, Hitosugi T, Wang Z, Wang L, Ho TH, Liu J; ''Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia.''; Elife, 2017 PubMed Europe PMC Scholia
- Asfa AS, Qiu B, Wee S, Choi H, Gunaratne J, Tergaonkar V; ''Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.''; Sci Rep, 2016 PubMed Europe PMC Scholia
- Grahn TH, Zhang Y, Lee MJ, Sommer AG, Mostoslavsky G, Fried SK, Greenberg AS, Puri V; ''FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes.''; Biochem Biophys Res Commun, 2013 PubMed Europe PMC Scholia
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