p38 MAPK signaling pathway (Canis familiaris)

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1-8Stress: Osmotic shockg-radiation, AnisomycinFASL, InflammatoryCytokines, UV, etc.?Translation??DNA transcriptionGrowth Factors, UVTrophic Factors, etc.??Cytokines Production,Apoptosis, etc.TRAF2TGFBR1MAP2K4MEF2DMAPKAPK5MAP2K6TRADDMYCApoptosisMAP3K9RAC1PLA2G4AELK1SHC1DAXXMAPK14HSPB1HMGN1MAPKAPK2MAPKAPK2ATF2MAPK14RIPK1DDIT3MKNK1TGFB2CDC42HRASGRB2STAT1RASGRF1MAXMAP3K5RPS6KA5MAP3K7MAP3K1CREB1Transcription factors


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP400 (r95117) with a 100.0% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  2. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  3. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  4. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  5. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  6. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  7. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  8. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
122865view08:06, 27 May 2022EgonwMade a pathway clickable
116820view10:16, 14 May 2021EweitzModified title
95738view13:24, 19 January 2018Mkutmonupdated homology conversion
95120view15:04, 16 November 2017Mkutmonadded missing homology converter comment source
68539view22:24, 5 July 2013MaintBotUpdated to 2013 gpml schema
67567view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
40695view21:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
38710view19:30, 23 September 2010AlexanderPico
38229view21:09, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38228view21:08, 27 August 2010Khanspers
38189view23:05, 23 August 2010Khansperstest
38188view23:04, 23 August 2010Khanspers
38187view23:03, 23 August 2010KhanspersReverted to version '23:39, 12 February 2010' by Khanspers
38186view23:02, 23 August 2010Khanspers
35725view23:39, 12 February 2010KhanspersDescription and bibliography
33979view18:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32253view12:56, 15 August 2009MaintBotFixed text labels
31771view12:08, 14 August 2009MaintBotFixed group labels
31275view20:00, 13 August 2009MaintBotFixed text labels
30723view22:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF2GeneProductENSCAFG00000013332 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1386
ApoptosisPathwayWP254 (WikiPathways)
CDC42GeneProductENSCAFG00000014707 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:998
CREB1GeneProductENSCAFG00000013510 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1385
DAXXGeneProductENSCAFG00000000981 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1616
DDIT3GeneProductENSCAFG00000030112 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1649
ELK1GeneProductENSCAFG00000015178 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2002
GRB2GeneProductENSCAFG00000030297 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2885
HMGN1GeneProductENSCAFG00000010045 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3150
HRASGeneProductENSCAFG00000031029 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3265
HSPB1GeneProductENSCAFG00000013544 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3315
MAP2K4GeneProductENSCAFG00000017851 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6416
MAP2K6GeneProductENSCAFG00000010758 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5608
MAP3K1GeneProductENSCAFG00000006917 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4214
MAP3K5GeneProductENSCAFG00000000251 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4217
MAP3K7GeneProductENSCAFG00000003123 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6885
MAP3K9GeneProductENSCAFG00000016679 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4293
MAPK14GeneProductENSCAFG00000001378 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1432
MAPKAPK2GeneProductENSCAFG00000011432 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9261
MAPKAPK5GeneProductENSCAFG00000008745 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8550
MAXGeneProductENSCAFG00000016212 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4149
MEF2DGeneProductENSCAFG00000016806 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4209
MKNK1GeneProductENSCAFG00000004205 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8569
MYCGeneProductENSCAFG00000001086 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4609
PLA2G4AGeneProductENSCAFG00000013778 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5321
RAC1GeneProductENSCAFG00000015716 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5879
RASGRF1GeneProductENSCAFG00000014053 (Ensembl)
  • PDZ domain containing guanine nucleotide exchange
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5923
RIPK1GeneProductENSCAFG00000009321 (Ensembl)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8737
RPS6KA5GeneProductENSCAFG00000017543 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9252
SHC1GeneProductENSCAFG00000017156 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6464
STAT1GeneProductENSCAFG00000009797 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6772
TGFB2GeneProductENSCAFG00000010815 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7042
TGFBR1GeneProductENSCAFG00000002528 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7046
TRADDGeneProductENSCAFG00000020382 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8717
TRAF2GeneProductENSCAFG00000019541 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7186

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1154"
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