G1 to S cell cycle control (Rattus norvegicus)

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1bCyclin EspG2 Phase-M phaseCyclin DsG1/S Cell CycleuupE2fcakeDNA replicationG1 CyclinDependant CyclasesCyclinDTTTCC/GCGCpDegradationG1/S transition CyclinDependent Kinasesphosphorylation of proteinsinvolved in G1/S transitionuorigin recognition complexpbG1 PhaseRbDNA polymerasesedp1pCheckpointinactivepCell cycle DNA replication genesG1/S transition PhaseAtf6bCdkn1cPrim2Tp53E2f6Myt1Ccna1Rpa1E2f3Creb3l3Rb1CDKN2DCdkn2bCdk6Cdk4Mcm4Wee1PolePrim1Tfdp1LOC100362927Mcm3Ccne1Cdk2Orc6Ccnb1Ccne2Cdk1Mcm5Cdc45Gadd45aTfdp1Orc3Tfdp2CDKCcnd2Cdk7CDKN2AE2f1Rbl1Rb1Ccne1Pola2Mnat1Cdc25aE2f2Mcm7Cdk6CcnhE2f5PcnaCdkn1aMycCcng2Ccnd1Creb3l4Tp53Cdk7Rb1Creb3Cdkn1bMcm6Creb3l1CDKOrc5Cdk2E2fMcm2Orc4Ccnd3E2f4Orc2Ccne1Mdm2Rpa2Pole2Cdkn2cAtmOrc1Cdk4Creb1E2fCdKCyclinDCdK


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP45 (r95145) with a 92.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95749view13:54, 19 January 2018MkutmonHomology conversion update
71777view20:31, 17 October 2013MaintBotAutomated update of data sources
69353view18:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
67267view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
47766view05:20, 6 April 2012Khanspersupdated xrefs
41665view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
35823view21:56, 17 February 2010KhanspersAdded lit ref
35822view21:55, 17 February 2010KhanspersModified description
34060view19:05, 9 December 2009MaintBotAutomatic update of empty xrefs
32403view17:03, 15 August 2009MaintBotFixed text labels
32058view13:33, 14 August 2009MaintBotFixed group labels
31434view21:03, 13 August 2009MaintBotFixed text labels
31019view01:07, 30 July 2009MaintBotConverted from Homo sapiens
21409view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:G1 to S cell cycle Reactome]] moved to [[Pathway:WP348]]: Moved to stable identifier
8070view13:46, 7 January 2008MaintBot[[Pathway:Rat:G1 to S cell cycle Reactome]] moved to [[Pathway:Rattus norvegicus:G1 to S cell cycle Reactome]]: Renaming species
7657view16:07, 18 December 2007MaintBotfixed category names
7228view12:41, 4 November 2007MaintBotAdded categories to GPML
6544view22:20, 22 May 2007A.C.Zambongpml file for [[Rat:G1_to_S_cell_cycle_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Atf6bGeneProductENSRNOG00000000431 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1388
AtmGeneProductENSRNOG00000029773 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:472
CDKGeneProduct
CDKN2AGeneProductNo homologues found for original id L:1029
CDKN2DGeneProductNo homologues found for original id L:1032
Ccna1GeneProductENSRNOG00000014052 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8900
Ccnb1GeneProductENSRNOG00000058539 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:891
Ccnd1GeneProductENSRNOG00000020918 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:595
Ccnd2GeneProductENSRNOG00000057710 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:894
Ccnd3GeneProductENSRNOG00000050258 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:896
Ccne1GeneProductENSRNOG00000014786 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:898
Ccne2GeneProductENSRNOG00000008055 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9134
Ccng2GeneProductENSRNOG00000002089 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:901
CcnhGeneProductENSRNOG00000031656 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:902
Cdc25aGeneProductENSRNOG00000020737 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:993
Cdc45GeneProductENSRNOG00000050071 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8318
Cdk1GeneProductENSRNOG00000000632 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:983
Cdk2GeneProductENSRNOG00000006469 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1017
Cdk4GeneProductENSRNOG00000025602 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1019
Cdk6GeneProductENSRNOG00000009258 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1021
Cdk7GeneProductENSRNOG00000018510 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1022
Cdkn1aGeneProductENSRNOG00000000521 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1026
Cdkn1bGeneProductENSRNOG00000007249 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1027
Cdkn1cGeneProductENSRNOG00000059500 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1028
Cdkn2bGeneProductENSRNOG00000006735 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1030
Cdkn2cGeneProductENSRNOG00000008956 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1031
Creb1GeneProductENSRNOG00000013412 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1385
Creb3GeneProductENSRNOG00000016452 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10488
Creb3l1GeneProductENSRNOG00000005413 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:90993
Creb3l3GeneProductENSRNOG00000032202 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:84699
Creb3l4GeneProductENSRNOG00000023493 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:148327
E2fGeneProduct
E2f1GeneProductENSRNOG00000016708 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1869
E2f2GeneProductENSRNOG00000047741 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1870
E2f3GeneProductENSRNOG00000029273 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1871
E2f4GeneProductENSRNOG00000015708 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1874
E2f5GeneProductENSRNOG00000010760 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1875
E2f6GeneProductENSRNOG00000004449 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1876
Gadd45aGeneProductENSRNOG00000005615 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1647
LOC100362927GeneProductENSRNOG00000037481 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6119
Mcm2GeneProductENSRNOG00000016316 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4171
Mcm3GeneProductENSRNOG00000012543 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4172
Mcm4GeneProductENSRNOG00000001833 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4173
Mcm5GeneProductENSRNOG00000014336 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4174
Mcm6GeneProductENSRNOG00000003703 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4175
Mcm7GeneProductENSRNOG00000001349 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4176
Mdm2GeneProductENSRNOG00000006304 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4193
Mnat1GeneProductENSRNOG00000007267 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4331
MycGeneProductENSRNOG00000004500 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609
Myt1GeneProductENSRNOG00000017346 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4661
Orc1GeneProductENSRNOG00000008841 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4998
Orc2GeneProductENSRNOG00000012558 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4999
Orc3GeneProductENSRNOG00000008314 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23595
Orc4GeneProductENSRNOG00000005021 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5000
Orc5GeneProductENSRNOG00000011519 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5001
Orc6GeneProductENSRNOG00000024043 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23594
PcnaGeneProductENSRNOG00000021264 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5111
Pola2GeneProductENSRNOG00000020906 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23649
Pole2GeneProductENSRNOG00000004242 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5427
PoleGeneProductENSRNOG00000037449 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5426
Prim1GeneProductENSRNOG00000031993 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5557
Prim2GeneProductENSRNOG00000012486 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5558
Rb1GeneProductENSRNOG00000016029 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5925
Rbl1GeneProductENSRNOG00000006921 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5933
Rpa1GeneProductENSRNOG00000003123 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6117
Rpa2GeneProductENSRNOG00000013005 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6118
Tfdp1GeneProductENSRNOG00000019222 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7027
Tfdp2GeneProductENSRNOG00000011241 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7029
Tp53GeneProductENSRNOG00000010756 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7157
Wee1GeneProductENSRNOG00000010017 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7465

Annotated Interactions

No annotated interactions
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