G1 to S cell cycle control (Pan troglodytes)

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1bCyclin EspG2 Phase-M phaseCyclin DsG1/S Cell CycleuupE2fcakeDNA replicationG1 CyclinDependant CyclasesCyclinDTTTCC/GCGCpDegradationG1/S transition CyclinDependent Kinasesphosphorylation of proteinsinvolved in G1/S transitionuorigin recognition complexpbG1 PhaseRbDNA polymerasesedp1pCheckpointinactivepCell cycle DNA replication genesG1/S transition PhaseCREBL1CDKN1CPRIM2ATP53E2F6MYT1CCNA1RPA1E2F3CREB3L3RB1CDKN2DCDKN2BCDK6CDK4MCM4WEE1POLEPRIM1TFDP1RPA3MCM3CCNE1CDK2ORC6CCNB1CCNE2CDK1MCM5CDC45GADD45ATFDP1ORC3TFDP2CDKCCND2CDK7CDKN2AE2F1RBL1RB1CCNE1POLA2MNAT1CDC25AE2F2MCM7CDK6CCNHE2F5PCNACDKN1AMYCCCNG2CCND1CREB3L4TP53CDK7RB1CREB3CDKN1BMCM6CREB3L1CDKORC5CDK2E2fMCM2ORC4CCND3E2F4ORC2CCNE1MDM2RPA2POLE2CDKN2CATMORC1CDK4CREB1E2fCdKCyclinDCdK


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP45 (r95145) with a 93.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95751view13:54, 19 January 2018MkutmonHomology conversion update
69254view18:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
67272view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
48163view20:20, 9 May 2012MaintBotUpdating from human to fix xrefs
41561view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
35832view22:17, 17 February 2010KhanspersAdded lit ref
35831view22:16, 17 February 2010KhanspersModified description
34291view22:01, 9 December 2009MaintBotAutomatic update of empty xrefs
33608view09:59, 1 December 2009MaintBotRemoved group label
31622view22:19, 13 August 2009MaintBotFixed text labels
30528view21:52, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProductENSPTRG00000004250 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:472
CCNA1GeneProductENSPTRG00000005784 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8900
CCNB1GeneProductENSPTRG00000016942 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:891
CCND1GeneProductENSPTRG00000052519 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:595
CCND2GeneProductENSPTRG00000004549 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:894
CCND3GeneProductENSPTRG00000018164 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:896
CCNE1GeneProductENSPTRG00000010782 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:898
CCNE2GeneProductENSPTRG00000020433 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9134
CCNG2GeneProductENSPTRG00000016196 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:901
CCNHGeneProductENSPTRG00000017063 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:902
CDC25AGeneProductENSPTRG00000014879 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:993
CDC45GeneProductENSPTRG00000014064 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8318
CDKGeneProduct
CDK1GeneProductENSPTRG00000002528 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:983
CDK2GeneProductENSPTRG00000005070 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1017
CDK4GeneProductENSPTRG00000005147 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1019
CDK6GeneProductENSPTRG00000019400 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1021
CDK7GeneProductENSPTRG00000016946 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1022
CDKN1AGeneProductENSPTRG00000018107 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1026
CDKN1BGeneProductENSPTRG00000004707 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1027
CDKN1CGeneProductENSPTRG00000003182 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1028
CDKN2AGeneProductNo homologues found for original id L:1029
CDKN2BGeneProductENSPTRG00000049465 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1030
CDKN2CGeneProductENSPTRG00000000726 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1031
CDKN2DGeneProductENSPTRG00000010477 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1032
CREB1GeneProductENSPTRG00000043959 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1385
CREB3GeneProductENSPTRG00000020918 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10488
CREB3L1GeneProductENSPTRG00000003543 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:90993
CREB3L3GeneProductENSPTRG00000010295 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:84699
CREB3L4GeneProductENSPTRG00000001368 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:148327
CREBL1GeneProductENSPTRG00000043301 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1388
E2F1GeneProductENSPTRG00000013404 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1869
E2F2GeneProductENSPTRG00000000330 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1870
E2F3GeneProductENSPTRG00000023584 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1871
E2F4GeneProductENSPTRG00000031180 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1874
E2F5GeneProductENSPTRG00000020384 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1875
E2F6GeneProductENSPTRG00000011661 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1876
E2fGeneProduct
GADD45AGeneProductENSPTRG00000000842 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1647
MCM2GeneProductENSPTRG00000015345 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4171
MCM3GeneProductENSPTRG00000018275 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4172
MCM4GeneProductENSPTRG00000020230 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4173
MCM5GeneProductENSPTRG00000014299 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4174
MCM6GeneProductENSPTRG00000012498 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4175
MCM7GeneProductENSPTRG00000019472 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4176
MDM2GeneProductENSPTRG00000005203 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4193
MNAT1GeneProductENSPTRG00000006412 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4331
MYCGeneProductENSPTRG00000020581 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4609
MYT1GeneProductENSPTRG00000032477 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4661
ORC1GeneProductENSPTRG00000000738 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4998
ORC2GeneProductENSPTRG00000012795 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4999
ORC3GeneProductENSPTRG00000018408 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23595
ORC4GeneProductENSPTRG00000012515 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5000
ORC5GeneProductENSPTRG00000019561 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5001
ORC6GeneProductENSPTRG00000008080 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23594
PCNAGeneProductENSPTRG00000013222 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5111
POLA2GeneProductENSPTRG00000003870 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23649
POLE2GeneProductENSPTRG00000048697 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5427
POLEGeneProductENSPTRG00000045365 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5426
PRIM1GeneProductENSPTRG00000022987 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5557
PRIM2AGeneProductENSPTRG00000044256 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5558
RB1GeneProductENSPTRG00000005864 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5925
RBL1GeneProductENSPTRG00000013469 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5933
RPA1GeneProductENSPTRG00000008539 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6117
RPA2GeneProductENSPTRG00000000420 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6118
RPA3GeneProductENSPTRG00000018927 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6119
TFDP1GeneProductENSPTRG00000048704 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7027
TFDP2GeneProductENSPTRG00000015479 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7029
TP53GeneProductENSPTRG00000008703 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7157
WEE1GeneProductENSPTRG00000003350 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7465

Annotated Interactions

No annotated interactions
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