mapk cascade (Danio rerio)

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1, 2GiGqp38 MAPK PathwayNucleusStress Activated PathwaysActivatedRap1GAPGrowth and MitogenesisComplexGb and Ggnrasmap2k4aGDPmapk3map2k6hrasamap2k2ambpbelk1mapk12bmap3k3brafmapk10mapk14amap3k2map3k12SIPA1MAP2K3raf1aKRASmap3k1rrasplcb3map2k4amap2map2k7mapk1GTPmap2k1rasa3junApoptosisarafRapGAPII


Description

The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP422 (r95146) with a 90.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC Scholia
  2. Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116826view10:19, 14 May 2021EweitzModified title
95770view14:24, 19 January 2018MkutmonHomology conversion update
86983view14:32, 15 July 2016MkutmonOntology Term : 'mitogen activated protein kinase signaling pathway' added !
68640view04:54, 6 July 2013MaintBotUpdated to 2013 gpml schema
62804view17:46, 2 May 2013Mkutmonremove datasource annotations without identifier
62786view16:32, 2 May 2013MaintBotUpdated UniProt data source
40808view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
34197view21:27, 9 December 2009MaintBotAutomatic update of empty xrefs
32325view13:27, 15 August 2009MaintBotFixed text labels
31931view12:55, 14 August 2009MaintBotFixed group labels
31360view20:33, 13 August 2009MaintBotFixed text labels
31053view01:23, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
GDPMetabolite146-91-8 (CAS)
GTPMetabolite2564-35-4 (CAS)
KRASGeneProductNo homologues found for original id L:3845
MAP2K3GeneProductNo homologues found for original id L:5606
RapGAPIIGeneProduct
SIPA1GeneProductENSDARG00000076697 (Ensembl)
  • not confirmed SwissProt ID - mu: SPA1 MOUSE
  • Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6494
arafGeneProductENSDARG00000054533 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:369
brafGeneProductENSDARG00000017661 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:673
elk1GeneProductENSDARG00000078066 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2002
hrasaGeneProductENSDARG00000098497 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3265
junGeneProductENSDARG00000043531 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3725
map2GeneProductENSDARG00000055052 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4133
map2k1GeneProductENSDARG00000007825 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5604
map2k2aGeneProductENSDARG00000006609 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5605
map2k4aGeneProductENSDARG00000063583 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416
map2k6GeneProductENSDARG00000099184 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5608
map2k7GeneProductENSDARG00000008279 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5609
map3k12GeneProductENSDARG00000103651 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7786
map3k1GeneProductENSDARG00000098405 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214
map3k2GeneProductENSDARG00000062884 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10746
map3k3GeneProductENSDARG00000060348 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4215
mapk10GeneProductENSDARG00000102730 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5602
mapk12bGeneProductENSDARG00000006409 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6300
mapk14aGeneProductENSDARG00000000857 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1432
mapk1GeneProductENSDARG00000027552 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5594
mapk3GeneProductENSDARG00000070573 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5595
mbpbGeneProductENSDARG00000089413 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4155
nrasGeneProductENSDARG00000038225 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4893
plcb3GeneProductENSDARG00000068246 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5331
raf1aGeneProductENSDARG00000096415 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5894
rasa3GeneProductENSDARG00000063371 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:22821
rrasGeneProductENSDARG00000006553 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6237

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1343"
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