Apoptosis (Mus musculus)

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315CaspActivator of Cell DeathpFas LigandpApoptosisDNA FragmentationDegradationbbeMitochondrionIGF1R signaling pathwaybInterferon regulatory factorsep53 RelatedInhibitor of Cell DeathPmaip1MIR29B1MIR29ACasp9Mdm2Bak1Traf3Irf1Nfkb1FasBirc2DiabloAkt1GzmcTnfrsf21BadNfkbiaCasp1Ripk1Irf2NfkbibLtaCasp4Irf6Casp3Prf1Tnfrsf1aIgf1rRelaChukBaxApaf1Tnfrsf1bCASP10Birc3BidTnfrsf25Mapk10Traf1IkbkbIrf5DffaCYCSNfkbibBBC3Irf3Casp2HrkTrp73Scaf11Casp7MycTnfIgf2CraddIkbkgBokTraf2CflarBcl2l2Pik3r1TraddBirc5Igf1Tnfrsf10bJunBnip3lDffbTraddBcl2Tnfrsf1aIrf7RelaBcl2l1Irf4NfkbieTrp534Map2k4Ripk1CDKN2ACasp8XiapBadNfkbiaFaslTnfsf10NfkbieHellsNfkb1FaddMcl1Casp6Bcl2l11Map3k1Trp63MIR29B2


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP254 (r95107) with a 92.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  2. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia
  3. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  4. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  5. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95784view14:36, 19 January 2018MkutmonHomology conversion update
89986view19:02, 6 October 2016Mkutmonfixed unconnected lines
82218view02:08, 16 September 2015AlexanderPicoredirected interactions directed to mitochondria for biopax conversion
69153view18:18, 8 July 2013MaintBotUpdated to 2013 gpml schema
67049view09:59, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
47965view13:15, 23 April 2012MartijnVanIerselUpdated group styles
47964view13:14, 23 April 2012MartijnVanIerselAdded cytosol compartment
47963view13:10, 23 April 2012MartijnVanIerselupdated mitochondrion
47745view19:21, 5 April 2012Thomasfixed wrongly annotated genes
41341view00:26, 2 March 2011MaintBotRemoved redundant pathway information and comments
35103view13:10, 11 February 2010MartijnVanIerselAdded lit. ref.
34407view23:06, 9 December 2009MaintBotAutomatic update of empty xrefs
32837view19:26, 14 September 2009MaintBotAdded xrefs
31859view12:34, 14 August 2009MaintBotFixed group labels
30858view00:09, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProductENSMUSG00000001729 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:207
Apaf1GeneProductENSMUSG00000019979 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:317
BBC3GeneProductNo homologues found for original id L:27113
BadGeneProductENSMUSG00000024959 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:572
Bak1GeneProductENSMUSG00000057789 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:578
BaxGeneProductENSMUSG00000003873 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:581
Bcl2GeneProductENSMUSG00000057329 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:596
Bcl2l11GeneProductENSMUSG00000027381 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10018
Bcl2l1GeneProductENSMUSG00000007659 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:598
Bcl2l2GeneProductENSMUSG00000089682 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:599
BidGeneProductENSMUSG00000004446 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:637
Birc2GeneProductENSMUSG00000057367 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:329
Birc3GeneProductENSMUSG00000032000 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:330
Birc5GeneProductENSMUSG00000017716 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:332
Bnip3lGeneProductENSMUSG00000022051 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:665
BokGeneProductENSMUSG00000026278 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:666
CASP10GeneProductNo homologues found for original id L:843
CDKN2AGeneProductNo homologues found for original id L:1029
CYCSGeneProductNo homologues found for original id L:54205
Casp1GeneProductENSMUSG00000025888 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:834
Casp2GeneProductENSMUSG00000029863 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:835
Casp3GeneProductENSMUSG00000031628 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:836
Casp4GeneProductENSMUSG00000033538 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:837
Casp6GeneProductENSMUSG00000027997 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:839
Casp7GeneProductENSMUSG00000025076 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:840
Casp8GeneProductENSMUSG00000026029 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:841
Casp9GeneProductENSMUSG00000028914 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:842
CflarGeneProductENSMUSG00000026031 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8837
ChukGeneProductENSMUSG00000025199 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1147
CraddGeneProductENSMUSG00000045867 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8738
DffaGeneProductENSMUSG00000028974 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1676
DffbGeneProductENSMUSG00000029027 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1677
DiabloGeneProductENSMUSG00000029433 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:56616
FaddGeneProductENSMUSG00000031077 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8772
FasGeneProductENSMUSG00000024778 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:355
FaslGeneProductENSMUSG00000000817 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:356
GzmcGeneProductENSMUSG00000079186 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3002
HellsGeneProductENSMUSG00000025001 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3070
HrkGeneProductENSMUSG00000046607 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8739
Igf1GeneProductENSMUSG00000020053 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3479
Igf1rGeneProductENSMUSG00000005533 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3480
Igf2GeneProductENSMUSG00000048583 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3481
IkbkbGeneProductENSMUSG00000031537 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3551
IkbkgGeneProductENSMUSG00000004221 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8517
Irf1GeneProductENSMUSG00000018899 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3659
Irf2GeneProductENSMUSG00000031627 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3660
Irf3GeneProductENSMUSG00000003184 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3661
Irf4GeneProductENSMUSG00000021356 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3662
Irf5GeneProductENSMUSG00000029771 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3663
Irf6GeneProductENSMUSG00000026638 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3664
Irf7GeneProductENSMUSG00000025498 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3665
JunGeneProductENSMUSG00000052684 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725
LtaGeneProductENSMUSG00000024402 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4049
MIR29AGeneProduct
MIR29B1GeneProduct
MIR29B2GeneProduct
Map2k4GeneProductENSMUSG00000033352 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416
Map3k1GeneProductENSMUSG00000021754 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4214
Mapk10GeneProductENSMUSG00000046709 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5602
Mcl1GeneProductENSMUSG00000038612 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4170
Mdm2GeneProductENSMUSG00000020184 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4193
MycGeneProductENSMUSG00000022346 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4609
Nfkb1GeneProductENSMUSG00000028163 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4790
NfkbiaGeneProductENSMUSG00000021025 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4792
NfkbibGeneProductENSMUSG00000030595 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4793
NfkbieGeneProductENSMUSG00000023947 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4794
Pik3r1GeneProductENSMUSG00000041417 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5295
Pmaip1GeneProductENSMUSG00000024521 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5366
Prf1GeneProductENSMUSG00000037202 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5551
RelaGeneProductENSMUSG00000024927 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5970
Ripk1GeneProductENSMUSG00000021408 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8737
Scaf11GeneProductENSMUSG00000033228 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9169
TnfGeneProductENSMUSG00000024401 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7124
Tnfrsf10bGeneProductENSMUSG00000022074 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8795
Tnfrsf1aGeneProductENSMUSG00000030341 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7132
Tnfrsf1bGeneProductENSMUSG00000028599 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7133
Tnfrsf21GeneProductENSMUSG00000023915 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:27242
Tnfrsf25GeneProductENSMUSG00000024793 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8718
Tnfsf10GeneProductENSMUSG00000039304 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8743
TraddGeneProductENSMUSG00000031887 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8717
Traf1GeneProductENSMUSG00000026875 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7185
Traf2GeneProductENSMUSG00000026942 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7186
Traf3GeneProductENSMUSG00000021277 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7187
Trp53GeneProductENSMUSG00000059552 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7157
Trp63GeneProductENSMUSG00000022510 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8626
Trp73GeneProductENSMUSG00000029026 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7161
XiapGeneProductENSMUSG00000025860 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:331

Annotated Interactions

No annotated interactions
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