Tumor suppressor activity of SMARCB1 (Homo sapiens)
From WikiPathways
Description
SMARCB1 is a core subunit proteins of the SWI/SNF chromatin remodeling complex, which interact with transcription factors at promoters and enhancers to modulate gene expression. Renal medullary carcinomas have been found to be deficient in SMARCB1 (BAF47) due to mutations. This pathway represents a summary of target genes and pathways implicated in the tumor suppression activity of SMARCB1.
This pathway is modeled after figure 2 of "Oncogenic roles of SMARCB1/INI1 and its deficient
tumors" by Kohashi and Oda, https://www.ncbi.nlm.nih.gov/pubmed/28109176.Quality Tags
Ontology Terms
Bibliography
- Wang X, Haswell JR, Roberts CW; ''Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.''; Clin Cancer Res, 2014 PubMed Europe PMC Scholia
- Mora-Blanco EL, Mishina Y, Tillman EJ, Cho YJ, Thom CS, Pomeroy SL, Shao W, Roberts CW; ''Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5.''; Oncogene, 2014 PubMed Europe PMC Scholia
- Kohashi K, Oda Y; ''Oncogenic roles of SMARCB1/INI1 and its deficient tumors.''; Cancer Sci, 2017 PubMed Europe PMC Scholia
- Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW; ''Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.''; Cancer Cell, 2010 PubMed Europe PMC Scholia
- Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW, Dorsch M; ''Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.''; Nat Med, 2010 PubMed Europe PMC Scholia
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Annotated Interactions
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