Transcriptional cascade regulating adipogenesis (Homo sapiens)

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Peroxisome proliferator-activated receptor γ (PPARγ) lies at the core of the transcriptional cascade that regulates adipogenesis. The expression of Pparg is regulated by several pro-adipogenic (green) and anti-adipogenic (orange) factors. PPARγ itself is activated by an as-yet-uncharacterized ligand. CCAAT-enhancer-binding protein α (C/EBPα) is regulated through a series of inhibitory protein–protein interactions. Some transcription-factor families have several members that participate in adipogenesis, such as the Krüppel-like factors (KLFs). Black lines indicate effects on gene expression, whereas blue lines represent effects on protein activity.

 

Rosen et al. Figure 2a