ACE inhibitor pathway (Bos taurus)

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377EDHFBlood vesselsZona glomerulosa of the adrenal glandMesangial cells aroundblood vessels in the kidneysAGTACE InhibitorACEAGTR1TFsAngiotensin IIAngiotensin IRENCTSGACEAldosteroneAng 1-5TGFB1CMA1ProstacyclinBradykininCa++NOS3DeoxycorticosteroneNR3C2Ang 1-9MAS1CYP11B2BDKRB1TFsATP6AP2BDKRB2AGTR2ACE2KNG1Ang 1-771025109, 10261ACEACE2


Description

The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP554_96328 with a 90.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia
  2. Athyros VG, Mikhailidis DP, Kakafika AI, Tziomalos K, Karagiannis A; ''Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?''; Expert Opin Pharmacother, 2007 PubMed Europe PMC Scholia
  3. Ferreira AJ, Raizada MK; ''Are we poised to target ACE2 for the next generation of antihypertensives?''; J Mol Med, 2008 PubMed Europe PMC Scholia
  4. Bassett MH, White PC, Rainey WE; ''The regulation of aldosterone synthase expression.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC Scholia
  5. McDowell SE, Coleman JJ, Ferner RE; ''Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.''; BMJ, 2006 PubMed Europe PMC Scholia
  6. Maron BA, Leopold JA; ''Mineralocorticoid receptor antagonists and endothelial function.''; Curr Opin Investig Drugs, 2008 PubMed Europe PMC Scholia
  7. Batenburg WW, Jan Danser AH; ''The (pro)renin receptor: a new addition to the renin-angiotensin system?''; Eur J Pharmacol, 2008 PubMed Europe PMC Scholia
  8. Weir MR; ''Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?''; Clin Ther, 2007 PubMed Europe PMC Scholia
  9. Schwartz GL, Turner ST; ''Pharmacogenetics of antihypertensive drug responses.''; Am J Pharmacogenomics, 2004 PubMed Europe PMC Scholia
  10. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W; ''Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.''; Kidney Int, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117471view10:58, 21 May 2021EweitzModified title
105956view11:48, 16 August 2019MaintBotHMDB identifier normalization
96331view09:34, 8 March 2018Mkutmonremove redundant ontology tag
96330view09:34, 8 March 2018MkutmonOntology Term : 'angiotensin signaling pathway' added !
96329view09:33, 8 March 2018MkutmonUpdated homology conversion
80846view15:28, 30 June 2015Mkutmonhomology conversion
79145view05:51, 5 March 2015KhanspersModified title
79144view05:42, 5 March 2015KhanspersUpdated conversion from Hs
71401view19:00, 17 October 2013MaintBotAutomated update of data sources
67016view09:53, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
63332view21:13, 9 May 2013MaintBotUpdated to 2013 gpml schema
57076view20:11, 20 January 2013Egonw
40511view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
35048view09:36, 11 February 2010Thomasremoved genmapp notes (invalid link)
35040view09:29, 11 February 2010ThomasModified description
33754view23:59, 8 December 2009MaintBotAutomatic update of empty xrefs
31672view11:42, 14 August 2009MaintBotFixed group labels
30602view22:16, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACE InhibitorMetaboliteCHEBI:35457 (ChEBI)
ACE2GeneProductENSBTAG00000034402 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:59272
ACEGeneProductENSBTAG00000024950 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1636
AGTGeneProductENSBTAG00000012393 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:183
AGTR1GeneProductENSBTAG00000045633 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:185
AGTR2GeneProductENSBTAG00000040386 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:186
ATP6AP2GeneProductENSBTAG00000017801 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10159
AldosteroneMetaboliteHMDB00037 (HMDB)
Ang 1-5MetaboliteC15852 (KEGG Compound)
Ang 1-7Metabolite110354 (Chemspider)
Ang 1-9MetaboliteC15851 (KEGG Compound)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
BDKRB1GeneProductENSBTAG00000007052 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:623
BDKRB2GeneProductENSBTAG00000021717 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:624
BradykininMetaboliteHMDB04246 (HMDB)
CMA1GeneProductENSBTAG00000027033 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1215
CTSGGeneProductENSBTAG00000013234 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1511
CYP11B2GeneProductENSBTAG00000037824 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1585
Ca++MetaboliteHMDB00464 (HMDB)
DeoxycorticosteroneMetaboliteHMDB00016 (HMDB)
KNG1GeneProductENSBTAG00000005122 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3827
MAS1GeneProductENSBTAG00000031724 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4142
NOS3GeneProductENSBTAG00000017680 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4846
NR3C2GeneProductENSBTAG00000027182 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4306
ProstacyclinMetabolite114805 (PubChem-compound)
RENGeneProductENSBTAG00000021333 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5972
TFsGeneProduct
TGFB1GeneProductENSBTAG00000020457 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7040

Annotated Interactions

No annotated interactions
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