G1 to S cell cycle control (Danio rerio)

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1CheckpointupDNA polymerasesbCyclin DsppCell cycle DNA replication genesppinactiveueDependent KinasesG1/S Cell CycleG2 Phase-M phasecakbG1/S transition Cyclinphosphorylation of proteinsinvolved in G1/S transitionCyclin EspRbG1/S transition PhaseTTTCC/GCGCorigen recognitioncomplexDependent KinasesG1 PhaseG1 CyclinpuDegredationdp1eE2fDNA replicationE2fzgc:85772CREB3CDKmcm5zgc:77841zgc:66452cdk4e2f3ATME2F2ccneccneccnemyt1aCREB3L4gadd45aPOLE2E2fcdk6tfdp2zgc:114132mcm2CDC25AE2F4E2F1orc6lccnd2azgc:56264tp53cdkn1carpa1mdm2POLEMCM6ccnd3zgc:56598mcm4pcnaRB1orc1lCdkE2F5ORC2LCDC2ACDC2Atp53ccnd2borc3lzgc:101599cdkn2dCyclinDcdkn2a/bCDKN1Accng2zgc:110727RB1zgc:86724mcm3ccnb1prim1cdk4wee1TFDP1ccna1cdkn2czgc:85821RB1zgc:56310zgc:77827zgc:55680rpa2TFDP1E2F6CyclinDCREB1CDKN1Bzgc:85821MCM7RBL1creb3l1CDKCREBL1cdk6ccnd1Cdk


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.

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Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
96476view16:07, 15 March 2018Marvin M2Connected lines and annotated nodes
78353view09:36, 7 January 2015MaintBotadded missing graphIds
71508view19:21, 17 October 2013MaintBotAutomated update of data sources
68634view04:47, 6 July 2013MaintBotUpdated to 2013 gpml schema
67269view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
40800view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
35828view22:12, 17 February 2010KhanspersAdded lit ref and connections
35827view22:02, 17 February 2010KhanspersModified description
34189view21:24, 9 December 2009MaintBotAutomatic update of empty xrefs
21616view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:G1 to S cell cycle Reactome]] moved to [[Pathway:WP445]]: Moved to stable identifier
12016view08:44, 15 May 2008MaintBotAdded to category $category
12014view08:43, 15 May 2008A.C.ZambonUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProduct403064 (Entrez Gene)
CDC25AGeneProduct
CDC2AGeneProduct
CDKGeneProduct
CDKN1AGeneProduct100151416 (Entrez Gene)
CDKN1BGeneProduct368329 (Entrez Gene)
CREB1GeneProduct573207 (Entrez Gene)
CREB3GeneProduct
CREB3L4GeneProduct
CREBL1GeneProduct
CdkGeneProduct
CyclinDGeneProduct
E2F1GeneProductENSDARG00000103868 (Ensembl)
E2F2GeneProductENSDARG00000079233 (Ensembl)
E2F4GeneProduct406741 (Entrez Gene)
E2F5GeneProduct373090 (Entrez Gene)
E2F6GeneProduct
E2fGeneProduct
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2LGeneProduct
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RB1GeneProduct777733 (Entrez Gene)
RBL1GeneProduct795522 (Entrez Gene)
TFDP1GeneProduct393749 (Entrez Gene)
ccna1GeneProduct404206 (Entrez Gene)
ccnb1GeneProduct58025 (Entrez Gene)
ccnd1GeneProductENSDARG00000101637 (Ensembl)
ccnd2aGeneProductENSDARG00000051748 (Ensembl)
ccnd2bGeneProductENSDARG00000070408 (Ensembl)
ccnd3GeneProductENSDARG00000027391 (Ensembl)
ccneGeneProduct30188 (Entrez Gene)
ccng2GeneProduct266794 (Entrez Gene)
cdk4GeneProductENSDARG00000087937 (Ensembl)
cdk6GeneProductENSDARG00000070228 (Ensembl)
cdkn1caGeneProductENSDARG00000010878 (Ensembl)
cdkn2a/bGeneProductENSDARG00000037262 (Ensembl)
cdkn2cGeneProductENSDARG00000057610 (Ensembl)
cdkn2dGeneProductENSDARG00000094176 (Ensembl)
creb3l1GeneProductENSDARG00000015793 (Ensembl)
e2f3GeneProductENSDARG00000070463 (Ensembl)
gadd45aGeneProduct431763 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
mdm2GeneProduct30637 (Entrez Gene)
myt1aGeneProductENSDARG00000074030 (Ensembl)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
tfdp2GeneProduct338204 (Entrez Gene)
tp53GeneProduct30590 (Entrez Gene)
wee1GeneProduct327060 (Entrez Gene)
zgc:101599GeneProduct450080 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:114132GeneProduct541325 (Entrez Gene)
zgc:55680GeneProduct393141 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:66452GeneProduct406853 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)
zgc:85821GeneProduct405897 (Entrez Gene)
zgc:86724GeneProduct415165 (Entrez Gene)

Annotated Interactions

No annotated interactions
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