Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens)

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38188486883, 8587NucelusOther effectorsEpithelial-Mesenchymal TransitionHypoxiaDegradationTGFb and Ras/MAPKUbiquitin-mediateddegradationJAG1MEF2DGSK3BGDF15pre-miR-9-2MAP2K1NUBPLNRP2PROX1TGFB1FMNL2FrizzledCytokeratinsCollagenCTNNB1TRAF6FOXQ1HRASEIF5A2WNTTUSC3RAF1TGFBR1STRAPTP53CDH1RBPJAKT1ClaudinsSMAD4NOTCH1Tyrosine kinase receptorsMMPsJUPTWIST1TMPRSS4MAPK3PPNR2C2MAP2K3MAP2K6MAP2K4MAPK14MAPK8SHC1GRB2SOS1SOS2KRASMAP2K2MAPK1PI3KAKT2AKT3SNAI1SNAI2NOTCH2NOTCH3NOTCH4HIF1A88JAG2DLL1DLL3DLL4DLK1CDKL2TWIST2PCDH2ZEB2FOXC2FOXM1FN1SNAI1SNAI1PPPSNAI1PCTDSP1SNAI1PPPKD1PAK1LATS2TWIST1TWIST2PPTWIST1TWIST2ZEB2SumoZEB2SumoSUZ12RBBP4EEDEZH2ZEB1822TGFBR2TGFB2TGFB3MAPK11MAPK13MAPK12SNAI1PSMAD2SMAD3OccludinsDSPPKP1PKP2CRB3MPP5VTNMMP158MMP2MMP9ID1ID28CDH18ClaudinsOccludinsDSPCDH2FN1VTNSPARCITGA5CDH1PKP1PKP2CRB3TJP1CDH2VTN


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Miyaki M, Kuroki T; ''Role of Smad4 (DPC4) inactivation in human cancer.''; Biochem Biophys Res Commun, 2003 PubMed Europe PMC Scholia
  2. Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, Ethier SP, Miller F, Wu G; ''Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis.''; Cancer Res, 2011 PubMed Europe PMC Scholia
  3. Vu T, Datta PK; ''Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis.''; Cancers (Basel), 2017 PubMed Europe PMC Scholia
  4. Wang X, Wu F, Wang H, Duan X, Huang R, Tuersuntuoheti A, Su L, Yan S, Zhao Y, Lu Y, Li K, Yao J, Luo Z, Guo L, Liu J, Chen X, Hu H, Li X, Bao M, Bi X, Du B, Miao S, Cai J, Wang L, Zhou H, Ying J, Song W, Zhao H; ''PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation.''; J Exp Clin Cancer Res, 2020 PubMed Europe PMC Scholia
  5. Li Q, Wu J, Wei P, Xu Y, Zhuo C, Wang Y, Li D, Cai S; ''Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition.''; Am J Cancer Res, 2015 PubMed Europe PMC Scholia
  6. Yang C, Chen H, Tan G, Gao W, Cheng L, Jiang X, Yu L, Tan Y; ''FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer.''; Cancer Lett, 2013 PubMed Europe PMC Scholia
  7. Lamouille S, Xu J, Derynck R; ''Molecular mechanisms of epithelial-mesenchymal transition.''; Nat Rev Mol Cell Biol, 2014 PubMed Europe PMC Scholia
  8. Abba M, Patil N, Rasheed K, Nelson LD, Mudduluru G, Leupold JH, Allgayer H; ''Unraveling the role of FOXQ1 in colorectal cancer metastasis.''; Mol Cancer Res, 2013 PubMed Europe PMC Scholia
  9. Lu MH, Huang CC, Pan MR, Chen HH, Hung WC; ''Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9.''; Clin Cancer Res, 2012 PubMed Europe PMC Scholia
  10. Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD; ''Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.''; J Clin Oncol, 2008 PubMed Europe PMC Scholia
  11. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  12. Kranenburg O; ''Prometastatic NOTCH Signaling in Colon Cancer.''; Cancer Discov, 2015 PubMed Europe PMC Scholia
  13. Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A; ''Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.''; Pathol Res Pract, 2009 PubMed Europe PMC Scholia
  14. Takagi Y, Kohmura H, Futamura M, Kida H, Tanemura H, Shimokawa K, Saji S; ''Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.''; Gastroenterology, 1996 PubMed Europe PMC Scholia
  15. De Bosscher K, Hill CS, Nicolás FJ; ''Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.''; Biochem J, 2004 PubMed Europe PMC Scholia
  16. Koyama M, Ito M, Nagai H, Emi M, Moriyama Y; ''Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.''; Mutat Res, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128751view12:36, 21 February 2024EweitzUpgrade disease node
127351view18:25, 20 September 2023Khanspersupdated phospho sites
127236view20:17, 25 August 2023Khanspersadded lit ref and updated description
126531view23:07, 25 May 2023Khanspersupdated phosphorylation interaction type
118997view09:29, 8 June 2021FinterlyRemoved empty Comment
111457view23:37, 10 August 2020KhanspersAdded interaction between PDCD6 and RAF1
108129view10:28, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106393view21:28, 28 August 2019KhanspersModified description
105464view05:12, 8 August 2019KhanspersModified description
103784view20:45, 5 April 2019Khanspersunified node size and added lit refs for mutations
97604view12:00, 29 May 2018AMTanOntology Term : 'colon epithelial cell' added !
97583view22:40, 26 May 2018AlexanderPicoModified title
97138view22:02, 30 April 2018Khanspersadded cell label
97137view21:54, 30 April 2018KhanspersModified title
97006view23:30, 25 April 2018KhanspersModified title
96593view23:50, 22 March 2018KhanspersModified description
96592view23:17, 22 March 2018KhanspersOntology Term : 'disease of cellular proliferation' added !
96591view20:56, 22 March 2018KhanspersModified description
96590view20:45, 22 March 2018Khansperswork in progress
96586view16:45, 22 March 2018KhanspersOntology Term : 'colorectal cancer' added !
96585view04:27, 22 March 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDH2GeneProductENSG00000170558 (Ensembl)
CDKL2GeneProductENSG00000138769 (Ensembl)
CRB3GeneProductENSG00000130545 (Ensembl)
CTDSP1GeneProductENSG00000144579 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
ClaudinsGeneProduct
CollagenGeneProduct
CytokeratinsGeneProduct
DLK1GeneProductENSG00000185559 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DLL3GeneProductENSG00000090932 (Ensembl)
DLL4GeneProductENSG00000128917 (Ensembl)
DSPGeneProductENSG00000096696 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EIF5A2GeneProductENSG00000163577 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FMNL2GeneProductENSG00000157827 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
FOXC2GeneProductENSG00000176692 (Ensembl)
FOXM1GeneProductENSG00000111206 (Ensembl)
FOXQ1GeneProductENSG00000164379 (Ensembl)
FrizzledGeneProduct
GDF15GeneProductENSG00000130513 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
ID1GeneProductENSG00000125968 (Ensembl)
ID2GeneProductENSG00000115738 (Ensembl)
ITGA5GeneProductENSG00000161638 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
JAG2GeneProductENSG00000184916 (Ensembl)
JUPGeneProductENSG00000173801 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LATS2GeneProductENSG00000150457 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP2K4GeneProductENSG00000065559 (Ensembl)
MAP2K6GeneProductENSG00000108984 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MEF2DGeneProductENSG00000116604 (Ensembl)
MMP15GeneProductENSG00000102996 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MMPsGeneProduct
MPP5GeneProductENSG00000072415 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
NOTCH3GeneProductENSG00000074181 (Ensembl)
NOTCH4GeneProductENSG00000204301 (Ensembl)
NR2C2GeneProductENSG00000177463 (Ensembl)
NRP2GeneProductENSG00000118257 (Ensembl)
NUBPLGeneProductENSG00000151413 (Ensembl)
OccludinsGeneProduct
PAK1GeneProductENSG00000149269 (Ensembl)
PI3KGeneProductENSG00000166333 (Ensembl)
PKD1GeneProductENSG00000008710 (Ensembl)
PKP1GeneProductENSG00000081277 (Ensembl)
PKP2GeneProductENSG00000057294 (Ensembl)
PROX1GeneProductENSG00000117707 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
RBPJGeneProductENSG00000168214 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
SPARCGeneProductENSG00000113140 (Ensembl)
STRAPGeneProductENSG00000023734 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TJP1GeneProductENSG00000104067 (Ensembl)
TMPRSS4GeneProductENSG00000137648 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TUSC3GeneProductENSG00000104723 (Ensembl)
TWIST1GeneProductENSG00000122691 (Ensembl)
TWIST2GeneProductENSG00000233608 (Ensembl)
Tyrosine kinase receptorsGeneProduct
VTNGeneProductENSG00000109072 (Ensembl)
WNTGeneProduct
ZEB1GeneProductENSG00000148516 (Ensembl)
ZEB2GeneProductENSG00000169554 (Ensembl)
pre-miR-9-2GeneProductENSG00000284447 (Ensembl)

Annotated Interactions

No annotated interactions

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