CYP2E1 activation leading to neurodegeneration (Homo sapiens)

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1KE: Apoptosis (1513)AO: Neurodegeneration (1514)CYP2E1 activationKE: Unfolded Protein Response (1512)StressorsIncrease caspaseexpressionIncrease concentration of ROSBiomarker SBDP-145 increaseKE: Oxidative Stress (1510)MIE: CYP2E1 Activation (1508)SevofluraneAcetylcysteineTP53TG3CEIF2AK3titanium oxideethanolisofluraneERN1NFE2L2L(-)-Glutathione(oxidized)methoxyfluraneHalothaneBCL2IsoniazidMAPK8ATF6chlorzoxazoneacetaminophenEnfluraneSOD1


Description

CYP2E1 activation leading to neurodegeneration. This pathway is based on the Adverse Outcome Pathway by Jelle Broers on AOPWiki: https://aopwiki.org/aops/260 .

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Quality Tags

Ontology Terms

 

Bibliography

  1. ''https://aopwiki.org/aops/260''; ,

History

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CompareRevisionActionTimeUserComment
123534view06:37, 2 August 2022EgonwMade four pathways clickable
117649view11:43, 22 May 2021EweitzModified title
106790view13:27, 17 September 2019MaintBotHMDB identifier normalization
97425view14:18, 16 May 2018AdoBioInfoReplaced the textlabels with pathway nodes. Naisu.
97274view08:43, 7 May 2018AdoBioInfoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF6GeneProductENSG00000118217 (Ensembl)
AcetylcysteineMetaboliteCHEBI:17561 (ChEBI)
BCL2GeneProductENSG00000171791 (Ensembl)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
EnfluraneMetaboliteHMDB14373 (HMDB)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
IsoniazidMetaboliteHMDB15086 (HMDB)
L(-)-Glutathione(oxidized)MetaboliteCHEBI:17858 (ChEBI)
MAPK8GeneProductENSG00000107643 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
SOD1GeneProductENSG00000142168 (Ensembl)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
TP53TG3CGeneProductENSG00000205457 (Ensembl)
acetaminophenMetaboliteCHEBI:46195 (ChEBI)
chlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
ethanolMetaboliteCHEBI:16236 (ChEBI)
isofluraneMetaboliteCHEBI:6015 (ChEBI)
methoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
titanium oxideMetaboliteCHEBI:134438 (ChEBI)

Annotated Interactions

No annotated interactions

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