Genotoxicity pathway (Homo sapiens)

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243, 8, 1377, 16, 1716197, 167, 9, 13, 16, 17, 19...73, 8, 13773, 77107, 197, 1612, 14, 151, 3, 4, 8, 16...776, 7, 10, 1673117776, 167, 167, 167227, 167778877207, 11, 17517, 163, 197, 167, 16777, 137, 163, 8, 13163, 8, 133, 8, 131, 3, 4, 8, 13...713197, 169, 13, 192, 4, 7, 11, 16...7, 87, 1379, 197, 1616127, 16, 17, 21, 2227, 1636, 7, 1671412, 15717, 163, 8, 13797, 167712713, 1977, 167, 164, 7, 167196, 10, 193, 8, 16, 217777, 161627, 16, 177, 162, 7, 14-16, 19714987, 167, 16143, 813, 7, 8, 13713777, 167977, 167, 167777137, 167, 141677, 16, 193, 7, 16, 193, 8, 1331437, 16777, 1673, 8, 13, 16, 2119, 21, 227, 1687, 1673, 873, 8, 133, 1937, 11371673, 1673, 13, 193, 7, 12, 19, 213, 7, 163, 8, 13, 193, 7, 179, 191573, 8, 1377, 1673, 7, 11, 17167, 13, 16, 2371, 3, 4, 1633, 81677, 167, 16, 17, 2215, 167, 161573, 117, 167, 161373, 8, 133, 8, 137, 16777, 173, 8, 137, 133, 937, 13, 177, 16, 177152, 7, 16, 1873, 197, 14, 167, 16193, 773, 8, 1382, 79, 1973, 7, 177, 167, 1677711113, 777, 167, 1677, 163, 8, 1310, 12, 157117, 2173, 8, 137, 161631777173, 8, 137, 167-9, 16, 17, 21...1314177, 177, 221977, 1777, 117777, 162, 7, 151548774913, 166, 10, 1579147FBXO22E2F7PPM1DHIST1H2BGGXYLT1HIST1H2BMCDKN1ACCP110DCP1BID2B3GNT2TP53I3SEL1LTNFRSF17E2F8PRKAB2ITPR1ITPKCDUSP14HIST1H3DTRIM22MEX3BHIST1H2BCACTA2SERTAD1COILAMER1LCE1ERBM12BTM7SF3DAAM1EI24HIST1H2BISMAD5BLOC1S2CENPETIGARPRKAB1ARRDC4RPS27LRAPGEF2TOPORSLRRFIP2DDB2BRMS1LMDM2HIST1H2BNNLRX1RRM2BAENBTG2CBLBGADD45ACEBPDPTGER4PHLDA3IKBIPHIST1H2BBTRIAP1HIST1H1EUSP41PLK3SEMG2PCDH8


Description

This pathway describes the transcriptomic biomarker TGx-DDI genotoxicity assay developed to readily distinguishes DNA damage-inducing (DDI) agents from non-DDI agents in a high-throughput method.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
97441view22:09, 17 May 2018Linda.RieswijkReorganized and fixed unconnected lines
97398view21:01, 14 May 2018Linda.RieswijkFixed unconnected lines
97359view19:24, 10 May 2018Linda.RieswijkOntology Term : 'DNA damage response pathway' added !
97358view19:21, 10 May 2018Linda.RieswijkModified description
97355view19:02, 10 May 2018Linda.RieswijkModified description
97354view19:01, 10 May 2018Linda.RieswijkModified description
97352view18:58, 10 May 2018Linda.RieswijkNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTA2GeneProduct59 (Entrez Gene)
AENGeneProduct64782 (Entrez Gene)
AMER1GeneProduct139285 (Entrez Gene)
ARRDC4GeneProduct91947 (Entrez Gene)
B3GNT2GeneProduct10678 (Entrez Gene)
BLOC1S2GeneProduct282991 (Entrez Gene)
BRMS1LGeneProduct84312 (Entrez Gene)
BTG2GeneProduct7832 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CCP110GeneProduct9738 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CEBPDGeneProduct1052 (Entrez Gene)
CENPEGeneProduct1062 (Entrez Gene)
COILGeneProduct8161 (Entrez Gene)
DAAM1GeneProduct23002 (Entrez Gene)
DCP1BGeneProduct196513 (Entrez Gene)
DDB2GeneProduct1643 (Entrez Gene)
DUSP14GeneProduct11072 (Entrez Gene)
E2F7GeneProduct144455 (Entrez Gene)
E2F8GeneProduct79733 (Entrez Gene)
EI24GeneProduct9538 (Entrez Gene)
FBXO22GeneProduct26263 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
GXYLT1GeneProduct283464 (Entrez Gene)
HIST1H1EGeneProduct3008 (Entrez Gene)
HIST1H2BBGeneProduct3018 (Entrez Gene)
HIST1H2BCGeneProduct8347 (Entrez Gene)
HIST1H2BGGeneProduct8339 (Entrez Gene)
HIST1H2BIGeneProduct8346 (Entrez Gene)
HIST1H2BMGeneProduct8342 (Entrez Gene)
HIST1H2BNGeneProduct8341 (Entrez Gene)
HIST1H3DGeneProduct8351 (Entrez Gene)
ID2GeneProduct3398 (Entrez Gene)
IKBIPGeneProduct121457 (Entrez Gene)
ITPKCGeneProduct80271 (Entrez Gene)
ITPR1GeneProduct3708 (Entrez Gene)
LCE1EGeneProduct353135 (Entrez Gene)
LRRFIP2GeneProduct9209 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MEX3BGeneProduct84206 (Entrez Gene)
NLRX1GeneProduct79671 (Entrez Gene) Type your comment here
PCDH8GeneProduct5100 (Entrez Gene)
PHLDA3GeneProduct23612 (Entrez Gene)
PLK3GeneProduct1263 (Entrez Gene)
PPM1DGeneProduct8493 (Entrez Gene)
PRKAB1GeneProduct5564 (Entrez Gene)
PRKAB2GeneProduct5565 (Entrez Gene)
PTGER4GeneProduct5734 (Entrez Gene)
RAPGEF2GeneProduct9693 (Entrez Gene)
RBM12BGeneProduct389677 (Entrez Gene)
RPS27LGeneProduct6232 (Entrez Gene) Type your comment here
RRM2BGeneProduct50484 (Entrez Gene)
SEL1LGeneProduct6400 (Entrez Gene)
SEMG2GeneProduct6407 (Entrez Gene)
SERTAD1GeneProduct29950 (Entrez Gene)
SMAD5GeneProduct4090 (Entrez Gene)
TIGARGeneProduct57103 (Entrez Gene)
TM7SF3GeneProduct51768 (Entrez Gene)
TNFRSF17GeneProduct608 (Entrez Gene)
TOPORSGeneProduct10210 (Entrez Gene)
TP53I3GeneProduct9540 (Entrez Gene)
TRIAP1GeneProduct51499 (Entrez Gene)
TRIM22GeneProduct10346 (Entrez Gene)
USP41GeneProduct373856 (Entrez Gene)

Annotated Interactions

No annotated interactions

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