Extracellular vesicles in the crosstalk of cardiac cells (Homo sapiens)
From WikiPathways
Description
(A) FB-derived exosomes enriched with miR-21-3p or Spp1 and EGFR proteins are transferred to CMs, leading to CM hypertrophy. (B) EVs secreted from CMs or MSCs, as well as circulating EVs exert regulatory effects on CM apoptosis. (C) CM-derived exosomal HSP90 together with secreted IL-6 are able to activate STAT-3 signaling in cardiac FBs, leading to cardiac fibrosis; whereas CM-derived exosomes from exercised diabetic mice express high levels of miR-29b and miR-455, thus reducing cardiac fibrosis. (D) EVs secreted from CMs or MSCs are transferred to ECs, exerting pro- or anti-angiogenic activities.
Description from Bei et al.
Quality Tags
Ontology Terms
Saving...Bibliography
- Bei Y, Das S, Rodosthenous RS, Holvoet P, Vanhaverbeke M, Monteiro MC, Monteiro VVS, Radosinska J, Bartekova M, Jansen F, Li Q, Rajasingh J, Xiao J; ''Extracellular Vesicles in Cardiovascular Theranostics.''; Theranostics, 2017 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| A. Hypertrophy | Pathway | ||
| B. Apoptosis | Pathway | ||
| BIRC5 | GeneProduct | ENSG00000089685 (Ensembl)  | |
| C. Fibrosis | Pathway | ||
| CD63 | GeneProduct | ENSG00000135404 (Ensembl) | |
| CD81 | GeneProduct | ENSG00000110651 (Ensembl) | |
| D. Angiogenesis | Pathway | ||
| EGF | GeneProduct | ENSG00000138798 (Ensembl) | |
| EGFR | GeneProduct | ENSG00000146648 (Ensembl) | |
| ETS2 | GeneProduct | ENSG00000157557 (Ensembl) | |
| FGF | GeneProduct | ||
| GATA4 | GeneProduct | ENSG00000136574 (Ensembl) | |
| HSP20 | GeneProduct | ||
| HSP20 | GeneProduct | ENSG00000142168 (Ensembl) | |
| HSP70 | GeneProduct | ||
| HSP90 | GeneProduct | ||
| HSPB1 | GeneProduct | ENSG00000106211 (Ensembl) | |
| IGF1 | GeneProduct | ENSG00000017427 (Ensembl) | |
| IL6 | GeneProduct | ENSG00000136244 (Ensembl) | |
| MAPK Signaling | Pathway | WP382 (WikiPathways) | |
| MIR320A | GeneProduct | ENSG00000208037 (Ensembl) | |
| MIR455 | GeneProduct | ENSG00000207726 (Ensembl) | |
| MMP9 | GeneProduct | ENSG00000100985 (Ensembl) | |
| NF-kB Signaling | Pathway | ||
| PDGF | GeneProduct | ||
| PDLIM5 | GeneProduct | ENSG00000163110 (Ensembl) | |
| PTEN | GeneProduct | ENSG00000171862 (Ensembl) | |
| Renin angiotensin system (RAS) | Pathway | ||
| SOD1 | GeneProduct | ENSG00000142168 (Ensembl) | |
| SORBS2 | GeneProduct | ENSG00000154556 (Ensembl) | |
| SPP1 | GeneProduct | ENSG00000118785 (Ensembl) | |
| STAT3 | GeneProduct | ENSG00000168610 (Ensembl) | |
| TLR4 | GeneProduct | ENSG00000136869 (Ensembl) | |
| VEGFR2 | GeneProduct | ENSG00000128052 (Ensembl) | |
| mir-19a | GeneProduct | 406979 (Entrez Gene) | |
| mir-29b1 | GeneProduct | HGNC:31619 (HGNC) | |
| mir-29b2 | GeneProduct | HGNC:31620 (HGNC) | |
| mir21-3p | GeneProduct | HGNC:31586 (HGNC) | |
| p-Akt | GeneProduct |
Annotated Interactions
No annotated interactions
