Proteasome degradation (Danio rerio)

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p45 ATPase SubunitActivators ofE3/ProteinUbiquitin/E2 ComplexHOMOLOGY MAPPCatalytic Core (p45)Degrades only Peptides(PA700) (ATP dependent)Proteins to be DegradedPresentation by MHC class 1Proteasome 20SUbiquitin/ProteinProteasome 26 SUnfolds and DegradesAlpha subunitsLid subunitsBeta subunitsAMP Ubiquitin/E1 ComplexCytosolic ProteinsIntact ProteinsOxidatively DamagedATP20S ComplexHLA-Hpsmc6psmd10HLA-Bpsma5psmb7psmd1PSMA3ube2d3PSMA1psmd2HLA-Gpsmb3psmd13psme2ube2d2lube2bpsmc1psmc5psma2HIST1H2ABpsmd12psmb10psme3ube2d1bpsmd4bpsmc5psmd9psma8psmb8psmd7PSMB9psmd11NEDD4UBE1LPSMA6psmd3psmb2HLA-Ch2afzpsmd6psmb5psmc4IFNGpsma4psmd5h2afxpsmb1psmb4psmc3HLA-Epsme1psmd8ube1psmc2HLA-Fubcpsmb6HLA-JHLA-Arpn1rpn2


Description

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Individual proteins in the nucleus and cytosol, as well as in the endoplasmic reticulum (ER) and mitochondria, are degraded at widely differing rates that vary from minutes for some regulatory enzymes to days or weeks for proteins such as actin and myosin in skeletal muscle or months for hemoglobin in the red cell.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
117063view14:24, 16 May 2021EweitzModified title
97815view15:01, 9 June 2018EgonwUndo revision 97768 by [[Special:Contributions/Mick Eikelhof|Mick Eikelhof]] ([[User talk:Mick Eikelhof|Talk]]) Text cannot be copied from other websites.
97768view13:31, 7 June 2018Mick EikelhofModified description
91969view14:09, 7 April 2017LWackersConnected lines where possible.
91968view13:05, 7 April 2017LWackersUpdated annotations and text labels. Added a number of missing annotations.
85387view08:14, 11 May 2016EgonwFixed the data source.
84703view21:44, 15 March 2016KhanspersQuick edit to datanode annotation or property
68631view04:43, 6 July 2013MaintBotUpdated to 2013 gpml schema
67611view11:33, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
40797view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
34186view21:23, 9 December 2009MaintBotAutomatic update of empty xrefs
21241view11:31, 14 November 2008MaintBot[[Pathway:Danio rerio:Proteasome Degradation]] moved to [[Pathway:WP267]]: Moved to stable identifier
12072view08:46, 15 May 2008MaintBotAdded to category $category
12070view08:46, 15 May 2008NsalomonisUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
HIST1H2ABGeneProduct
HLA-AGeneProduct
HLA-BGeneProduct
HLA-CGeneProduct
HLA-EGeneProduct
HLA-FGeneProduct
HLA-GGeneProduct
HLA-HGeneProduct
HLA-JGeneProduct
IFNGGeneProduct
NEDD4GeneProduct
PSMA1GeneProduct
PSMA3GeneProduct
PSMA6GeneProduct
PSMB9GeneProduct
UBE1LGeneProduct
h2afxGeneProduct394048 (Entrez Gene)
h2afzGeneProduct573415 (Entrez Gene)
psma2GeneProduct554153 (Entrez Gene)
psma4GeneProduct326687 (Entrez Gene)
psma5GeneProduct403011 (Entrez Gene)
psma8GeneProduct406445 (Entrez Gene)
psmb10GeneProduct64280 (Entrez Gene)
psmb1GeneProduct445413 (Entrez Gene)
psmb2GeneProduct436882 (Entrez Gene)
psmb3GeneProduct573095 (Entrez Gene)
psmb4GeneProduct550499 (Entrez Gene)
psmb5GeneProduct30387 (Entrez Gene)
psmb6GeneProduct30388 (Entrez Gene) U13393
psmb7GeneProduct64278 (Entrez Gene)
psmb8GeneProduct30666 (Entrez Gene)
psmc1GeneProduct336786 (Entrez Gene)
psmc2GeneProduct393941 (Entrez Gene)
psmc3GeneProduct321947 (Entrez Gene)
psmc4GeneProduct326884 (Entrez Gene) PRS6_HUMAN
psmc5GeneProduct445285 (Entrez Gene) PRS6_HUMAN
psmc6GeneProduct321585 (Entrez Gene)
psmd10GeneProduct403085 (Entrez Gene)
psmd11GeneProduct322265 (Entrez Gene)
psmd12GeneProduct321898 (Entrez Gene)
psmd13GeneProduct393922 (Entrez Gene)
psmd1GeneProduct554967 (Entrez Gene)
psmd2GeneProduct393518 (Entrez Gene)
psmd3GeneProduct393544 (Entrez Gene)
psmd4bGeneProduct550287 (Entrez Gene)
psmd5GeneProduct550235 (Entrez Gene)
psmd6GeneProduct393261 (Entrez Gene)
psmd7GeneProduct327330 (Entrez Gene)
psmd8GeneProduct415221 (Entrez Gene)
psmd9GeneProduct436709 (Entrez Gene)
psme1GeneProduct30648 (Entrez Gene)
psme2GeneProduct30647 (Entrez Gene)
psme3GeneProduct30649 (Entrez Gene)
rpn1GeneProduct325561 (Entrez Gene)
rpn2GeneProduct335985 (Entrez Gene)
ubcGeneProduct777766 (Entrez Gene)
ube1GeneProduct406335 (Entrez Gene)
ube2bGeneProduct437020 (Entrez Gene)
ube2d1bGeneProduct324015 (Entrez Gene)
ube2d2lGeneProduct335444 (Entrez Gene)
ube2d3GeneProduct321832 (Entrez Gene)

Annotated Interactions

No annotated interactions

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