Mitochondrial fission and fusion (Homo sapiens)

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1, 2Mitochondrial fusionProhibitinOPA1FIS1MFN1BNIP3MFN2MIB1MFN1MFN2BNIP3DRP1DRP1FIS1BAXMitochondrial fissionBCL2Endophilin-A1PDLMTP18OPA1


Description

"The dynamics of mitochondrial fission and fusion. The localization, as well as some interaction and modification of the principal proteins involved in the two processes are shown. Once dephosphorylated, DRP1 is recruited to the outer membrane by FIS1 or by another, unknown, component. The oligomerization of DRP1 is followed by constriction of the membrane and mitochondrial fission. The pro-fusion proteins (MFNs on the outer membrane and OPA1 on the inner membrane) oligomerize to induce fusion of the membranes. Other additional components of the machinery are shown. BAX, BCL2-associated X protein; BNIP3, BCL2/E1B 19 kDa-interacting protein 3; CAMK1a, calcium/calmodulin-dependent protein kinase 1a; DRP1, dynamin-related protein 1; FIS1, fission protein 1; GDAP1, ganglioside-induced differentiation-associated protein 1; l-OPA1, long form of OPA1; MFN, mitofusin; MIB, mitofusin-binding protein; MTP18, mitochondrial protein 18 kDa; OPA1, optic atrophy 1; PKA, protein kinase A; PLD, phospholipase D; s‑OPA1: short form of OPA1." Luca Scorrano et al 2010

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Bibliography

  1. Campello S, Scorrano L; ''Mitochondrial shape changes: orchestrating cell pathophysiology.''; EMBO Rep, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134826view11:56, 27 July 2024EweitzFix reference. Previous pathway title and references were for a different pathway.
134825view11:54, 27 July 2024EweitzModified description
134824view11:52, 27 July 2024EweitzModified description
134823view11:52, 27 July 2024EweitzModified description
134822view11:49, 27 July 2024EweitzModified title
134821view11:48, 27 July 2024EweitzModified title
134820view11:46, 27 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134819view11:44, 27 July 2024EweitzEconomize layout
129501view07:45, 3 May 2024Ash iyerPDL changed to PLD1.
129500view07:31, 3 May 2024Ash iyerModified description
129494view07:28, 2 May 2024SusanConnected lines
129493view07:20, 2 May 2024SusanChange the pathway labels
109037view18:17, 14 February 2020KhanspersOntology Term : 'mitochondria fusion pathway' added !
109036view18:17, 14 February 2020KhanspersOntology Term : 'mitochondria fission pathway' added !
109035view18:16, 14 February 2020KhanspersOntology Term : 'PW:0002075' removed !
109034view18:16, 14 February 2020KhanspersOntology Term : 'altered mitochondria fission pathway' added !
97926view08:50, 25 June 2018MadeomugaModified description
97925view08:47, 25 June 2018MadeomugaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171552 (Ensembl)
BNIP3GeneProductENSG00000176171 (Ensembl)
DRP1 GeneProductENSG00000087470 (Ensembl)
Endophilin-A1GeneProductENSG00000107295 (Ensembl)
FIS1GeneProductENSG00000214253 (Ensembl)
MFN1GeneProductENSG00000171109 (Ensembl)
MFN2GeneProductENSG00000116688 (Ensembl)
MIB1GeneProductENSG00000101752 (Ensembl)
MTP18 GeneProductENSG00000242114 (Ensembl)
Mitochondrial fissionPathway
Mitochondrial fusionPathway
OPA1GeneProductENSG00000198836 (Ensembl)
PDLGeneProductENSG00000075651 (Ensembl)
ProhibitinProteinA8K401 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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