Thermogenesis (Homo sapiens)

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Lipid dropletNucleusmTORC1HeatComplexesI II III IVSecretedRPS6KA1cAMP SignalingPathwayFADH2NADHRPS6KA3UCP1PRKG1RPTORTGACTL6BPNPLA2fatty acidRPS6KA2FRS2RHEBPRKACACPT2PPARGC1APPARGGNASCarnitineRPS6KA6CREB3FGF21H+AcylcarnitineCPT1ARPS6KDM1AcAMPSLC25A29GlycerolADPSLC25A20TCA CyclePRDM16DGZNF516FGF21HRASAcetyl-CoAMGLLUCP1KDM3BcGMPMAP3K5Electron Transport ChainATF2GRB2SIRT6ANPARID1BTSC1PLIN1H+ADRB3mTOR SignalingPathwayAcyl-CoARegulation oflipolysis in adipocyteMGACSL1RPS6KB1Coenzyme APPPPADCY1PADCY2ADCY3ADCY5ADCY6ADCY7ADCY8ADCY9ADCY4ADCY10CNR1NPR1KLBFGFR1BNPSOS1SOS2KRASNRASTSC2PMTORMLST8AKT1S1RPS6KB2PPRKG2LIPEPPRKACBPRKACGMAPK SignalingPathwayMAP2K3PMAPK14PMAPK11PMAPK13PMAPK12PCREB1CREB3L4CREB3L2CREB3L3CREB3L1CREB5KDM3AACTBSMARCA2SMARCA4SMARCB1SMARCC1SMARCC2SMARCD1SMARCD2SMARCD3SMARCE1ACTG1DPF3DPF1ARID1AACTL6AUCP1fatty acidATPAcyl-CoAAcylcarnitineCoenzyme ACarnitineH+ACSL3ACSL4ACSL5ACSL6CPT1BCPT1COxidativePhosphorylationATPaseH+H+H+H+


Description

Thermogenesis is an essential process of heat production in warm-blooded animals and some plants.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
123362view05:01, 18 July 2022EgonwMade a few pathways clickable
106178view12:07, 16 August 2019MaintBotHMDB identifier normalization
102774view08:51, 24 January 2019EgonwMissed one.
102772view21:11, 23 January 2019EgonwFixed the casing of two ChEBI identifiers (prefix should be CHEBI: instead of ChEBI:)
98055view06:12, 13 July 2018Fehrhartadded ID for MAPK signaling pathway
98002view10:12, 30 June 2018EgonwAdded an identifier for endocannabinoids.
98001view09:22, 30 June 2018EgonwI missed one :(
98000view08:15, 30 June 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97999view20:05, 29 June 2018KhanspersOntology Term : 'electron transport chain pathway' added !
97998view20:04, 29 June 2018KhanspersOntology Term : 'brown fat cell' added !
97997view20:04, 29 June 2018KhanspersOntology Term : 'beige adipocyte' added !
97996view20:03, 29 June 2018KhanspersAdded endocannabinoids etc
97995view19:43, 29 June 2018Khansperswork in progress
97994view19:24, 29 June 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACSL1GeneProductENSG00000151726 (Ensembl)
ACSL3GeneProductENSG00000123983 (Ensembl)
ACSL4GeneProductENSG00000068366 (Ensembl)
ACSL5GeneProductENSG00000197142 (Ensembl)
ACSL6GeneProductENSG00000164398 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTL6AGeneProductENSG00000136518 (Ensembl)
ACTL6BGeneProductENSG00000077080 (Ensembl)
ADCY10GeneProductENSG00000143199 (Ensembl)
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY2GeneProduct108 (Entrez Gene)
ADCY3GeneProduct109 (Entrez Gene)
ADCY4GeneProductENSG00000129467 (Ensembl)
ADCY5GeneProductENSG00000173175 (Ensembl)
ADCY6GeneProductENSG00000174233 (Ensembl)
ADCY7GeneProductENSG00000121281 (Ensembl)
ADCY8GeneProductENSG00000155897 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
ADPMetaboliteCHEBI:2342 (ChEBI)
ADRB3GeneProductENSG00000188778 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
ANPMetaboliteCHEBI:80233 (ChEBI)
ARID1AGeneProductENSG00000117713 (Ensembl)
ARID1BGeneProductENSG00000049618 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
ATPMetaboliteCHEBI:2359 (ChEBI)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
Acyl-CoAMetaboliteCHEBI:2455 (ChEBI)
AcylcarnitineMetaboliteChEBI:75659 (ChEBI)
BNPMetaboliteCHEBI:80234 (ChEBI)
CNR1GeneProductENSG00000118432 (Ensembl)
CPT1AGeneProductENSG00000110090 (Ensembl)
CPT1BGeneProductENSG00000205560 (Ensembl)
CPT1CGeneProductENSG00000169169 (Ensembl)
CPT2GeneProductENSG00000157184 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
CREB3GeneProductENSG00000107175 (Ensembl)
CREB3L1GeneProduct90993 (Entrez Gene)
CREB3L2GeneProductENSG00000182158 (Ensembl)
CREB3L3GeneProductENSG00000060566 (Ensembl)
CREB3L4GeneProductENSG00000143578 (Ensembl)
CREB5GeneProductENSG00000146592 (Ensembl)
CarnitineMetaboliteCHEBI:3424 (ChEBI)
Coenzyme AMetaboliteCHEBI:3771 (ChEBI)
DGMetaboliteCHEBI:4481 (ChEBI)
DPF1GeneProductENSG00000011332 (Ensembl)
DPF3GeneProductENSG00000205683 (Ensembl)
Electron Transport ChainPathwayWP111 (WikiPathways)
FADH2MetaboliteCHEBI:4957 (ChEBI)
FGF21GeneProductENSG00000105550 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FRS2GeneProductENSG00000166225 (Ensembl)
GNASGeneProductENSG00000087460 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GlycerolMetaboliteCHEBI:5448 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
HRASGeneProductENSG00000174775 (Ensembl)
KDM1AGeneProductENSG00000004487 (Ensembl)
KDM3AGeneProductENSG00000115548 (Ensembl)
KDM3BGeneProductENSG00000120733 (Ensembl)
KLBGeneProductENSG00000134962 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LIPEGeneProductENSG00000079435 (Ensembl)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAPK Signaling PathwayPathway
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MGMetaboliteCHEBI:35759 (ChEBI)
MGLLGeneProductENSG00000074416 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NADHMetaboliteCHEBI:7423 (ChEBI)
NPR1GeneProductENSG00000169418 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
PLIN1GeneProductENSG00000166819 (Ensembl)
PNPLA2GeneProductENSG00000177666 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRDM16GeneProductENSG00000142611 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKG1GeneProductENSG00000185532 (Ensembl)
PRKG2GeneProductENSG00000138669 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPS6GeneProductENSG00000137154 (Ensembl)
RPS6KA1GeneProductENSG00000117676 (Ensembl)
RPS6KA2GeneProductENSG00000071242 (Ensembl)
RPS6KA3GeneProductENSG00000177189 (Ensembl)
RPS6KA6GeneProductENSG00000072133 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPS6KB2GeneProductENSG00000175634 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
Regulation of

lipolysis in

adipocyte		Pathway
SIRT6GeneProductENSG00000077463 (Ensembl)
SLC25A20GeneProductENSG00000178537 (Ensembl)
SLC25A29GeneProductENSG00000197119 (Ensembl)
SMARCA2GeneProductENSG00000080503 (Ensembl)
SMARCA4GeneProductENSG00000127616 (Ensembl)
SMARCB1GeneProductENSG00000099956 (Ensembl)
SMARCC1GeneProductENSG00000173473 (Ensembl)
SMARCC2GeneProductENSG00000139613 (Ensembl)
SMARCD1GeneProductENSG00000066117 (Ensembl)
SMARCD2GeneProductENSG00000108604 (Ensembl)
SMARCD3GeneProductENSG00000082014 (Ensembl)
SMARCE1GeneProductENSG00000073584 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCA CyclePathwayWP78 (WikiPathways)
TGMetaboliteCHEBI:75844 (ChEBI)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
UCP1GeneProductENSG00000109424 (Ensembl)
ZNF516GeneProductENSG00000101493 (Ensembl)
cAMP Signaling PathwayPathway
cAMPMetaboliteCHEBI:1325 (ChEBI)
cGMPMetaboliteCHEBI:1327 (ChEBI)
fatty acidMetaboliteCHEBI:35366 (ChEBI)
mTOR Signaling PathwayPathwayWP1471 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4321"
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