NRF2-ARE regulation (Homo sapiens)

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31332NucleusAutoregulatoryloopProteasomedegradation of NRF2AREPhase II enzymesERKGSK3BPCEBPBMAFPI3KGCLCJNKP38NRF2PPPKCHO-1SLC7A11NQO1GSTA2GCLMCEBPBPNRF2KEAP1NRF2PP1Early response to stressorLate response to stressorFYNSRCYES1NRF2PINSRPGAM5NRF2KEAP1CUL3RBX1KEAP1OKEAP1CUL3RBX1FYNSRCYES1


Description

draft

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  2. Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  3. Niture SK, Khatri R, Jaiswal AK; ''Regulation of Nrf2-an update.''; Free Radic Biol Med, 2014 PubMed Europe PMC Scholia
  4. Vomhof-Dekrey EE, Picklo MJ Sr; ''The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism.''; J Nutr Biochem, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140180view17:25, 4 August 2025EgonwModified description
140161view14:53, 2 August 2025Ash iyerAdded protein complex nodes
140138view19:13, 31 July 2025Khanspersadded note for ptm
134796view02:54, 27 July 2024EweitzEconomize layout
134795view02:53, 27 July 2024EweitzEconomize layout
127491view17:22, 11 October 2023Khanspers
127272view00:01, 1 September 2023Khanspersupdated phosphosite
127257view18:29, 28 August 2023KhanspersAdded literature reference and updated description
98705view18:20, 28 September 2018KhanspersModified title
98704view18:19, 28 September 2018KhanspersModified title
98702view18:14, 28 September 2018KhanspersModified description
98701view18:06, 28 September 2018KhanspersOntology Term : 'nuclear factor, erythroid 2 like 2 signaling pathway' added !
98700view18:05, 28 September 2018Khanspersfixed connection
98699view18:03, 28 September 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CEBPBGeneProduct1051 (Entrez Gene)
CUL3GeneProductENSG00000036257 (Ensembl)
ERKGeneProduct2048 (Entrez Gene)
FYNGeneProductENSG00000010810 (Ensembl)
GCLCGeneProduct2729 (Entrez Gene)
GCLMGeneProduct2730 (Entrez Gene)
GSK3BGeneProductENSG00000082701 (Ensembl)
GSTA2GeneProduct2939 (Entrez Gene)
HO-1GeneProduct3162 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
JNKGeneProduct5599 (Entrez Gene)
KEAP1GeneProduct9817 (Entrez Gene) Cysteine residues are oxidized, causing KEAP1 to dislocate from NRF2
MAFGeneProduct4094 (Entrez Gene)
NQO1GeneProduct1728 (Entrez Gene)
NRF2GeneProduct4780 (Entrez Gene)
P38GeneProduct7965 (Entrez Gene)
PGAM5GeneProductENSG00000247077 (Ensembl)
PI3KGeneProduct5290 (Entrez Gene)
PKCGeneProduct5578 (Entrez Gene)
RBX1GeneProductENSG00000100387 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
YES1GeneProductENSG00000176105 (Ensembl)

Annotated Interactions

No annotated interactions

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