Ciliary landscape (Homo sapiens)

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1NucleusBBSomeTRAPPcomplex 3complex 44complex 21HSF1/HSPA1L/MAPRE2complex 19complex 29Basal bodyNOTARL/NPHP/UNC119GIDIQ/CALM1complex 47complex 15Exosomecomplex 49U5-snRNPcomplex 39complex 12complex FOX/RFXDynein-1complex 5complex 31complex 16COP9 signalosomecomplex 9IFT-B1complex 5TUBG/NMEcomplex 53ANKS/NEKU4/U6-snRNPProteasomeMCMcomplex 28Axonemecomplex 7IFT-Acomplex 26MAK/ICK/KIAA0556Cell membraneCiliumTransition zoneTFAP2DCDH23LSM4IFT122ECHS1IFT57COPS8IFT74NINLCD2BP2MCM5RBM14MCM8TFAP2CMCM7COPS1RABEP2AIMP1DCAF7SSNA1IFT43CTBP2CLUAP1IFT140MCM4TNKS1BP1COPS5COPS4YAP1MFAP1RAB2ANDUFA9MCM10CAMK2AMCM9MCM2DGKETTC8TFAP2AMCM3CNOT1DYNLL1IFT81CNOT10GLADCAF11TSSC1MCM6COPS6USH1CCOPS2CDR2GDI1NUP133EXOC8VPS4ABBS9LZTFL1CTSAHDAC2NUDCDYNLL2UQCC1SNRPB2ACSL3NUP88DVL3RQCD1UBE2D2COPS7ATFAP2EWEE1CBSBBIP1NME8RAB3IL1HDAC1DNPEPMSH2TFAP2BERFIFT27RAB14IFT46EXOSC9LCA5CEP170RB1NDUFA5WNK1MKS1SNAP29COPS7BTMED1RAB21CLTCREBBPH3F3AARFGAP3APCARL8BCOPS3ARHGDIAPOM121EHBP1CTNNB1IFT20RPGRRHBDD2EFTUD2CCDC40NFKB1SPATA7CNOT6LIFT52CEP97Cytosolcomplex 46IFT-B1IFT88IFT80IFT172IFT-B2DynactinDynein-2IFT-B2IFT22TTC30BTTC30ATTC26HSPB11CLUAP1TRAF3IP1EXOC6BEXOC6EXOC7EXOC5EXOC2EXOC3EXOC1EXOC4exocyst-2exocyst-1EXOC2EXOC3EXOC1EXOC6BEXOC6EXOC7EXOC5EXOC4RALBBBSomeBBS1BBS2BBS5BBS4BBS7TCTEX1D2PAFAH1B1DYNLRB2DYNLRB1MAPRE2Dynein-1WDR60DYNLT1WDR34DYNLT3TIPRLTCTEX1D2DYNLT3DYNC1H1DYNLT1PAFAH1B1DYNC1I2DYNC1LI1Dynein-2WHRNVIMZYG11BGLB1NEFLNEFMXPNPEP3NEFGID4ARMC8RANBP9RMND5BRANBP10MAEAMKLN1GID8LCN2WDR26YPEL5EFHC2PGRMC2UBE2HRMND5AHTRA2DDX5ZMYND19RAB8AANKS6ANKS3NEK7NEK8MYL6TBC1D4CEP290IQGAP2CALM1LRPPRCIQCB1IQGAP3IQGAP1COX6CSTOMMYL6BRAC1EIF5BEXOSC2EXOSC4EXOSC7ExosomeTCEB2 PSMD13EHD3AAR2DOCK5FUZPSMD8APMAPSMC4AGPAT2PSMD7AFG3L2RNGTTPSMC6PSMD12VAPBINTUPSMC4


Description

Ciliary landscape pathway - according to Boldt et al. 2016 - was constructed using the results of affinity proteomics for 217 proteins with known or suspected involvement in ciliary function, resulting in a landscape of 1319 proteins and 4905 interactions of which the most important are shown here (derived from Figure 1). Ciliary function is impaired in a wide spectrum of diseases (ciliopathies) including polycystic kidney disease, Usher syndrome, Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Jeune syndrome.

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Bibliography

  1. Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R; ''An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.''; Nat Commun, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
102218view20:44, 11 December 2018Khanspersfixed unconnected interactions
98719view14:32, 1 October 2018FehrhartProteasome
98718view14:20, 1 October 2018FehrhartIQ/GAP
98717view14:07, 1 October 2018FehrhartGID
98716view13:45, 1 October 2018FehrhartNEF
98715view13:21, 1 October 2018Fehrhartadded BBSome and dynein complexes
98714view12:52, 1 October 2018Fehrhartadded complexes IFTB1 and B2
98599view14:12, 20 September 2018FehrhartModified description
98598view14:06, 20 September 2018FehrhartOntology Term : 'ciliopathy' added !
98597view14:05, 20 September 2018FehrhartOntology Term : 'transport pathway' added !
98596view13:56, 20 September 2018FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AAR2GeneProductENSG00000131043 (Ensembl)
ACSL3GeneProductENSG00000123983 (Ensembl)
AFG3L2GeneProductENSG00000141385 (Ensembl)
AGPAT2GeneProductENSG00000169692 (Ensembl)
AIMP1GeneProductENSG00000164022 (Ensembl)
ANKS3GeneProductENSG00000168096 (Ensembl)
ANKS6GeneProductENSG00000165138 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
APMAPGeneProductENSG00000101474 (Ensembl) no annotation found yet
ARFGAP3GeneProduct26286 (Entrez Gene)
ARHGDIAGeneProductENSG00000141522 (Ensembl)
ARL8BGeneProductENSG00000134108 (Ensembl)
ARMC8GeneProductENSG00000114098 (Ensembl)
BBIP1GeneProductENSG00000214413 (Ensembl)
BBS1GeneProductENSG00000174483 (Ensembl)
BBS2GeneProductENSG00000125124 (Ensembl)
BBS4GeneProductENSG00000140463 (Ensembl)
BBS5GeneProductENSG00000163093 (Ensembl)
BBS7GeneProductENSG00000138686 (Ensembl)
BBS9GeneProductENSG00000122507 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CBSGeneProductENSG00000160200 (Ensembl)
CCDC40GeneProductENSG00000141519 (Ensembl)
CD2BP2GeneProductENSG00000169217 (Ensembl)
CDH23GeneProductENSG00000107736 (Ensembl)
CDR2GeneProductENSG00000140743 (Ensembl)
CEP170GeneProductENSG00000143702 (Ensembl)
CEP290GeneProductENSG00000198707 (Ensembl)
CEP97GeneProductENSG00000182504 (Ensembl)
CLTGeneProductno idea what that should be
CLUAP1GeneProductENSG00000103351 (Ensembl)
CNOT10GeneProductENSG00000182973 (Ensembl)
CNOT1GeneProductENSG00000125107 (Ensembl)
CNOT6LGeneProductENSG00000138767 (Ensembl)
COPS1GeneProductno annotation found yet
COPS2GeneProductENSG00000166200 (Ensembl)
COPS3GeneProductENSG00000141030 (Ensembl)
COPS4GeneProductENSG00000138663 (Ensembl)
COPS5GeneProductCOPS5 (HGNC)
COPS6GeneProductENSG00000168090 (Ensembl)
COPS7AGeneProductENSG00000111652 (Ensembl)
COPS7BGeneProductENSG00000144524 (Ensembl)
COPS8GeneProductENSG00000198612 (Ensembl)
COX6CGeneProductENSG00000164919 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTSAGeneProductENSG00000064601 (Ensembl)
DCAF11GeneProductENSG00000100897 (Ensembl)
DCAF7GeneProductENSG00000136485 (Ensembl)
DDX5GeneProductENSG00000108654 (Ensembl)
DGKEGeneProductENSG00000153933 (Ensembl)
DNPEPGeneProductENSG00000123992 (Ensembl)
DOCK5GeneProductENSG00000147459 (Ensembl)
DVL3GeneProductENSG00000161202 (Ensembl)
DYNC1H1GeneProductENSG00000197102 (Ensembl)
DYNC1I2GeneProductENSG00000077380 (Ensembl)
DYNC1LI1GeneProductENSG00000144635 (Ensembl)
DYNLL1GeneProductENSG00000088986 (Ensembl)
DYNLL2GeneProductENSG00000264364 (Ensembl)
DYNLRB1GeneProductENSG00000125971 (Ensembl)
DYNLRB2GeneProductENSG00000168589 (Ensembl)
DYNLT1GeneProductENSG00000146425 (Ensembl)
DYNLT3GeneProductENSG00000165169 (Ensembl)
ECHS1GeneProductENSG00000127884 (Ensembl)
EFHC2GeneProductENSG00000183690 (Ensembl)
EFTUD2GeneProductENSG00000108883 (Ensembl)
EHBP1GeneProductENSG00000115504 (Ensembl)
EHD3GeneProductENSG00000013016 (Ensembl)
EIF5BGeneProductENSG00000158417 (Ensembl)
ERFGeneProductENSG00000105722 (Ensembl)
EXOC1GeneProductENSG00000090989 (Ensembl)
EXOC2GeneProductENSG00000112685 (Ensembl)
EXOC3GeneProductENSG00000180104 (Ensembl)
EXOC4GeneProductENSG00000131558 (Ensembl)
EXOC5GeneProductENSG00000070367 (Ensembl)
EXOC6BGeneProductENSG00000144036 (Ensembl)
EXOC6GeneProductENSG00000138190 (Ensembl)
EXOC7GeneProductENSG00000182473 (Ensembl)
EXOC8GeneProductENSG00000116903 (Ensembl)
EXOSC2GeneProductENSG00000130713 (Ensembl)
EXOSC4GeneProductENSG00000178896 (Ensembl)
EXOSC7GeneProductENSG00000075914 (Ensembl)
EXOSC9GeneProductENSG00000123737 (Ensembl)
FUZGeneProductENSG00000010361 (Ensembl)
GDI1GeneProductENSG00000203879 (Ensembl)
GID4GeneProductENSG00000141034 (Ensembl)
GID8GeneProductENSG00000101193 (Ensembl)
GLAGeneProductENSG00000102393 (Ensembl)
GLB1GeneProductENSG00000170266 (Ensembl)
H3F3AGeneProductENSG00000163041 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
HSPB11GeneProductENSG00000081870 (Ensembl)
HTRA2GeneProductENSG00000115317 (Ensembl)
IFT122GeneProductENSG00000163913 (Ensembl)
IFT140GeneProductENSG00000187535 (Ensembl)
IFT172GeneProductENSG00000138002 (Ensembl)
IFT20GeneProductENSG00000109083 (Ensembl)
IFT22GeneProductENSG00000128581 (Ensembl)
IFT27GeneProductENSG00000100360 (Ensembl)
IFT43GeneProductENSG00000119650 (Ensembl)
IFT46GeneProductENSG00000118096 (Ensembl)
IFT52GeneProductENSG00000101052 (Ensembl)
IFT57GeneProductENSG00000114446 (Ensembl)
IFT74GeneProductENSG00000096872 (Ensembl)
IFT80GeneProductENSG00000068885 (Ensembl)
IFT81GeneProductENSG00000122970 (Ensembl)
IFT88GeneProductENSG00000032742 (Ensembl)
INTUGeneProductENSG00000164066 (Ensembl) no annotation found yet
IQCB1GeneProductENSG00000173226 (Ensembl)
IQGAP1GeneProductENSG00000140575 (Ensembl)
IQGAP2GeneProductENSG00000145703 (Ensembl)
IQGAP3GeneProductENSG00000183856 (Ensembl)
LCA5GeneProductENSG00000135338 (Ensembl)
LCN2GeneProductENSG00000148346 (Ensembl)
LRPPRCGeneProductENSG00000138095 (Ensembl)
LSM4GeneProductENSG00000130520 (Ensembl)
LZTFL1GeneProductENSG00000163818 (Ensembl)
MAEAGeneProductENSG00000090316 (Ensembl)
MAPRE2GeneProductENSG00000166974 (Ensembl)
MCM10GeneProductENSG00000065328 (Ensembl)
MCM2GeneProductENSG00000073111 (Ensembl)
MCM3GeneProductENSG00000112118 (Ensembl)
MCM4GeneProductENSG00000104738 (Ensembl)
MCM5GeneProductENSG00000100297 (Ensembl)
MCM6GeneProductENSG00000076003 (Ensembl)
MCM7GeneProductENSG00000166508 (Ensembl)
MCM8GeneProductENSG00000125885 (Ensembl)
MCM9GeneProductENSG00000111877 (Ensembl)
MFAP1GeneProductENSG00000140259 (Ensembl)
MKLN1GeneProductENSG00000128585 (Ensembl)
MKS1GeneProductENSG00000011143 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MYL6BGeneProductENSG00000196465 (Ensembl)
MYL6GeneProductENSG00000092841 (Ensembl)
NDUFA5GeneProductENSG00000128609 (Ensembl)
NDUFA9GeneProductENSG00000139180 (Ensembl)
NEFLGeneProductENSG00000277586 (Ensembl)
NEFMGeneProductENSG00000104722 (Ensembl)
NEK7GeneProductENSG00000151414 (Ensembl)
NEK8GeneProductENSG00000160602 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NINLGeneProductENSG00000101004 (Ensembl)
NME8GeneProductENSG00000086288 (Ensembl)
NUDCGeneProductENSG00000090273 (Ensembl)
NUP133GeneProductENSG00000069248 (Ensembl)
NUP88GeneProductENSG00000108559 (Ensembl)
PAFAH1B1GeneProductENSG00000007168 (Ensembl)
PGRMC2GeneProductENSG00000164040 (Ensembl)
POM121GeneProductENSG00000196313 (Ensembl)
PSMC4GeneProductENSG00000013275 (Ensembl)
PSMC6GeneProductENSG00000100519 (Ensembl)
PSMD12GeneProductENSG00000197170 (Ensembl)
PSMD13GeneProductENSG00000185627 (Ensembl)
PSMD7GeneProductENSG00000103035 (Ensembl)
PSMD8GeneProductENSG00000099341 (Ensembl)
RAB14GeneProductENSG00000119396 (Ensembl)
RAB21GeneProductENSG00000080371 (Ensembl)
RAB2AGeneProductENSG00000104388 (Ensembl)
RAB3IL1GeneProductENSG00000167994 (Ensembl)
RAB8AGeneProductENSG00000167461 (Ensembl)
RABEP2GeneProductENSG00000177548 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RALBGeneProductENSG00000144118 (Ensembl)
RANBP10GeneProductENSG00000141084 (Ensembl)
RANBP9GeneProductENSG00000010017 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RBM14GeneProductENSG00000239306 (Ensembl)
RHBDD2GeneProductENSG00000005486 (Ensembl)
RMND5AGeneProductENSG00000153561 (Ensembl)
RMND5BGeneProductENSG00000145916 (Ensembl)
RNGTTGeneProductENSG00000111880 (Ensembl)
RPGRGeneProductENSG00000156313 (Ensembl)
RQCD1ProteinD5MQE1 (Uniprot-TrEMBL)
SMC4GeneProductENSG00000113810 (Ensembl)
SNAP29GeneProductENSG00000099940 (Ensembl)
SNRPB2GeneProductENSG00000125870 (Ensembl)
SPATA7GeneProductENSG00000042317 (Ensembl)
SSNA1GeneProductENSG00000176101 (Ensembl)
STOMGeneProductENSG00000148175 (Ensembl)
TBC1D4GeneProductENSG00000136111 (Ensembl)
TCEB2 GeneProductENSG00000138663 (Ensembl)
TCTEX1D2GeneProductENSG00000213123 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TFAP2BGeneProductENSG00000008196 (Ensembl)
TFAP2CGeneProductENSG00000087510 (Ensembl)
TFAP2DGeneProductENSG00000008197 (Ensembl)
TFAP2EGeneProductENSG00000116819 (Ensembl)
TIPRLGeneProductENSG00000143155 (Ensembl)
TMED1GeneProductENSG00000099203 (Ensembl)
TNKS1BP1GeneProductENSG00000149115 (Ensembl)
TRAF3IP1GeneProductENSG00000204104 (Ensembl)
TSSC1GeneProductENSG00000032389 (Ensembl)
TTC26GeneProductENSG00000105948 (Ensembl)
TTC30AGeneProductENSG00000197557 (Ensembl)
TTC30BGeneProductENSG00000196659 (Ensembl)
TTC8GeneProductENSG00000165533 (Ensembl)
UBE2D2GeneProductENSG00000131508 (Ensembl)
UBE2HGeneProductENSG00000186591 (Ensembl)
UQCC1GeneProductENSG00000101019 (Ensembl)
USH1CGeneProductENSG00000006611 (Ensembl)
VAPBGeneProductENSG00000124164 (Ensembl)
VIMGeneProductENSG00000026025 (Ensembl)
VPS4AGeneProductENSG00000132612 (Ensembl)
WDR26GeneProductENSG00000162923 (Ensembl)
WDR34GeneProductENSG00000119333 (Ensembl)
WDR60GeneProductENSG00000126870 (Ensembl)
WEE1GeneProductENSG00000166483 (Ensembl)
WHRNGeneProductENSG00000095397 (Ensembl)
WNK1GeneProductENSG00000060237 (Ensembl)
XPNPEP3GeneProductENSG00000196236 (Ensembl)
YAP1GeneProductENSG00000137693 (Ensembl)
YPEL5GeneProductENSG00000119801 (Ensembl)
ZMYND19GeneProductENSG00000165724 (Ensembl)
ZYG11BGeneProductENSG00000162378 (Ensembl)

Annotated Interactions

No annotated interactions

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