FABP4 in ovarian cancer (Homo sapiens)
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Description
Regulation of FABP4 in ovarian cancer. FABP4 (fatty acid binding protein) can substantially increase metastatic potential of ovarian cancer cells, and leads to more aggressive disease. Mir-409-3p negatively regulates FABP4 in ovarian cancer cells, and mir-409-3p is decreased in hypoxic conditions. Pink arrows indicates potential therapuetic therapeutic stratgeies; in Gharpure et al, DOPC nanoliposomes containing either miR-409-3p mimic or FABP4 siRNA was shown to inhibit tumor progression.
Description was adapted from Gharpure et al.
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Saving...Bibliography
- Gharpure KM, Pradeep S, Sans M, Rupaimoole R, Ivan C, Wu SY, Bayraktar E, Nagaraja AS, Mangala LS, Zhang X, Haemmerle M, Hu W, Rodriguez-Aguayo C, McGuire M, Mak CSL, Chen X, Tran MA, Villar-Prados A, Pena GA, Kondetimmanahalli R, Nini R, Koppula P, Ram P, Liu J, Lopez-Berestein G, Baggerly K, S Eberlin L, Sood AK; ''FABP4 as a key determinant of metastatic potential of ovarian cancer.''; Nat Commun, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
| Name | Type | Database reference | Comment |
|---|---|---|---|
| FABP4 | GeneProduct | ENSG00000170323 (Ensembl)  | |
| MIR409 | Rna | ENSG00000199107 (Ensembl) |
Annotated Interactions
No annotated interactions
