Selenoamino acid metabolism (Homo sapiens)

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2387, 813226143129, 3063810, 19, 2411, 261, 1235734133421162231233, 2732, 36, 3715, 3315, 33139, 18, 253, 154, 532, 36, 3717, 20cytosolheme RPS2 RPS16 FAU GSHRPS4Y2 KARS RPL26 tRNA(Sec)RPL24 PXLP pyruvic acidSEPHS2RPL32 NADP+GSSeSGRPS24 NADP+NAM NH3RPL18A 18S rRNA RPL35 RPL38 80S:Met-tRNAi:mRNA:SECISBP2:SecRPL6 RPL27 RPS7 RPS5 RPL18A FAD RPL10L RPL37A RPS27L H2ORPS13 RPL13A PAPSS1,2H2ORPS20 RPS24 RPL21 RPLP2 RPS29 RPL41 RPS25 SeCystaRPS3 RPS6 RPL28 PPiRPL8 RPL26L1 NADP+RPS8 5.8S rRNA RPS8 RPS15 H+H+RPL13 H2ORPL28 SECISBP2 RPS4Y1 K+ SARC APSe5S rRNA RPL12 RPS14 RPL30 RPLP0 RPL3L RPL34 RPL37 acceptorRPS28 ADP18S rRNA RPL34 2-acetamidoglucalH2ORPL3 RPS10 RPS27 HNMT RPL14 tRNA(Met)RPS9 RPS29 RPL13A RPL10 Met-tRNAi EEFSEC RPL35 RPL35 RPL38 H2ORPS7 RPS5 TXNRD1 RPL4 SeMet-tRNA(Met)RPL17 H2ORPS17 RPS2 RPL9 RPL41 RPS10 SECISBP2 AdoMetPSTK RPSA RPS14 RPS23 RPS19 RPL32 PiRPS15A RPL7 RPL36 RPL22L1 RPS27L RPL23A TNXRD1:FAD dimerRPL26 RPL19 RPL14 RPS19 Me2SeFAU EPRS RPL7A RPS26 bGalNAc derivativeRPL23A GTP RPS27A(77-156) EEFSEC RPS27 RPS3 RPS16 PPiRPL39L RPS15A RPS11 RPL37A RPL24 RPL18 EEFSEC RPL23A NADP+SEPSECStetramer:PXLPRPS5 RPL30 Met-tRNAi RPL28 NNMT SECISBP2RPL31 GSHPAPSS1,2RPS12 MeHist,N1MNA,MeGlyDARS MeSeHMTATPMeSeO2HNADP+RPS6 EEFSEC RPLP1 NH3RPS20 RPL40 RPL36 RPL11 RPL37 RPL8 RPS26 RPL18A NADPH28S rRNA RPS27 AdoHcyPAPSeAdoHcyRPLP2 AdoMetGSHH3PO4RPS2 RPL29 PAPGSR-2:FAD dimerRPL27A RPS26 RPS3A RPL27 RPL11 RPL3 RPS18 RPL35A Met-tRNAi RPS17 RPS3A RPL11 FAD RPS11 AMPCTH tetramer:PXLPSELPH+RPL8 MetTrans(1)ATPPiFAD Ceruloplasmin mRNA RPS12 RPL22 RPL39L GSR-2 RPS18 TNXRD1:FAD dimerRPL21 PAPSS2 RPL15 RPS21 RPL5 RPS24 RPL7 RPS13 RPL36AL RPL34 RPL3 RPL23 RPL22L1 RPL13 TNXRD1:FAD dimerRPS23 RPL3L RPS28 RPL18 AdoMetQARS RPL5 ATPSeO3(2-)RPL19 INMTHist,NAM,GlyRPS16 CTH RPLP1 RPS4X Ceruloplasmin mRNA Mg2+ H+GSSGH2ORPL26L1 AIMP1(1-312) RPS15 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTPSARS LARS L-SerFAD RPL39 5.8S rRNA RPL36A RPL12 RPL23 AMPCBS tetramerAdoSeMetAdoHcy2OBUTAGTP RPL15 RPL36A 28S rRNA RPL10L MeSebGalNacRPLP2 CTH SeMetATPMSDMRPS14 H2SeO4RPS12 RPSA RPS21 GSSebGalNacRPL23 RPL31 5S rRNA RPL29 RPL17 RPL6 GSSGRPL24 RPS10 RPL22L1 RPS15 NADPH5.8S rRNA RPL27 TXNRD1 RPL26 RPL36AL PPiRPL39L NADPHRPS27L RPS25 RPS20 RPL14 RPL36 SARS dimerGDP RPL4 RPL30 RPL13A RPL21 L-SerH2OH2O28S rRNA PXLP RPL32 RPL17 ATPRPS15A RPL35A RPS9 MAT1A multimersSec-tRNA(Sec) Sec-tRNA(Sec)RPL27A Sec H2Se5S rRNA RPS18 RPL10 RPS28 RPS4Y1 GTP MAT1A aminoacyl-tRNAsynthetasemultienzyme complexPAPSS1 RPL10A RPS17 AdeSeHCysreduced acceptorRPL40 EEFSEC:GTPRPS7 RPL37A RPL4 RPS8 H2ORPL29 RPL22 MeSeOHMeOH80S:Met-tRNAi:mRNARPS27A(77-156) RPL7A RPS29 RPS23 PXLP PXLP-CBS TXNRD1 H2ORPS4Y1 RPSA RPL31 PAPSeRATPRPL27A SCLY RARS PPiRPS3A Ser-tRNA(Sec)RPL10A RPS21 Mg2+ RPL15 RPS9 SEPSECS Ade-RibRPL6 ATPRPL39 MNA SCLY dimer:PXLPPAPSS1 RPLP1 RPS19 AIMP2 RPLP0 RPL7A ADPSec-tRNA(Sec):EEFSEC:GTP2OBUTARPL10A RPL39 RPL3L RPLP0 AMPbGalNAcHist RPL9 Sec-tRNA(Sec) GSHRPL26L1 RPL35A GSSeHNADPHRPS27A(77-156) L-AlaMe3Se+H+AdoHcyHSeMTH2OAHCYH+RPL40 RPL18 SecMARS PXLP RPS4X RPS4Y2 MeSecCeruloplasmin mRNA RPL13 RPL41 SeHCysRPL36AL CTH tetramer:PXLPPiMeHist GNMT RPL7 RPL5 RPL12 RPL37 FAU H2OSep-tRNA(Sec)RPS4Y2 RPS13 18S rRNA RPS4X IARS RPS3 H2OMeSeHRPS25 RPL19 EEF1E1 RPL22 NADPHRPL36A EEFSEC:GDPH+PAPSS2 RPL38 PSTK:Mg2+RPL10L RPL10 RPS11 RPL9 RPS6 Gly 28


Description

Selenium (Se) is a trace element essential for the normal function of the body. Selenoamino acids are defined as those amino acids where selenium has been substituted for sulphur. Selenium and sulphur share many chemical properties and so the substitution of normal amino acids with selenoamino acids has little effect on protein structure and function. Both inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can be introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) and then utilized for the de novo synthesis of Sec through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of Sec formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SEPSECS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

All nutritional selenium is metabolised into selenide directly or through methylselenol (MeSeH). Sec liberated from selenoproteins is transformed to Se(2-) by selenocysteine lyase (SCLY). SeMet liberated from general proteins and from free SeMet sources is transformed into Se(2-) either through MeSeH by cystathionine gamma-lyase (CTH) followed by demethylation (SeMet to CH3SeH to H2Se), or through Sec by SCLY after the trans-selenation pathway (SeMet to Sec to H2Se). MeSec is hydrolysed into MeSeH by CTH. Methylseleninic acid (MeSeO2H) is reduced to methylselenol. MeSeH is demethylated to Se(2-) for further utilization for selenoprotein synthesis or oxidised to selenite (SeO3(2-)) for excretion in the form of selenosugar. Additionally, MeSeH is further methylated to dimethylselenide (Me2Se) and trimethylselenonium (Me3Se+) for excretion. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 2408522
Reactome-version 
Reactome version: 63
Reactome Author 
Reactome Author: Williams, MG

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114774view16:26, 25 January 2021ReactomeTeamReactome version 75
113218view11:28, 2 November 2020ReactomeTeamReactome version 74
112442view15:38, 9 October 2020ReactomeTeamReactome version 73
101347view11:23, 1 November 2018ReactomeTeamreactome version 66
100885view20:57, 31 October 2018ReactomeTeamreactome version 65
100426view19:31, 31 October 2018ReactomeTeamreactome version 64
99976view16:15, 31 October 2018ReactomeTeamreactome version 63
99530view14:51, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99168view12:42, 31 October 2018ReactomeTeamreactome version 62
93759view13:34, 16 August 2017ReactomeTeamreactome version 61
93281view11:19, 9 August 2017ReactomeTeamreactome version 61
87653view08:55, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
86360view09:16, 11 July 2016ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
18S rRNA ProteinX03205 (EMBL)
2-acetamidoglucalMetaboliteCHEBI:73979 (ChEBI)
28S rRNA ProteinM11167 (EMBL)
2OBUTAMetaboliteCHEBI:30831 (ChEBI)
5.8S rRNA ProteinJ01866 (EMBL)
5S rRNA ProteinV00589 (EMBL)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTPComplexR-HSA-5359044 (Reactome)
80S:Met-tRNAi:mRNA:SECISBP2:SecComplexR-HSA-5359053 (Reactome)
80S:Met-tRNAi:mRNAComplexR-HSA-72505 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHCYProteinP23526 (Uniprot-TrEMBL)
AIMP1(1-312) ProteinQ12904 (Uniprot-TrEMBL)
AIMP2 ProteinQ13155 (Uniprot-TrEMBL)
AMPMetaboliteCHEBI:16027 (ChEBI)
APSeMetaboliteCHEBI:2485 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ade-RibMetaboliteCHEBI:16335 (ChEBI)
AdeSeHCysMetaboliteCHEBI:77028 (ChEBI)
AdoHcyMetaboliteCHEBI:16680 (ChEBI)
AdoMetMetaboliteCHEBI:15414 (ChEBI)
AdoSeMetMetaboliteCHEBI:9066 (ChEBI)
CBS tetramerComplexR-HSA-1614610 (Reactome)
CTH ProteinP32929 (Uniprot-TrEMBL)
CTH tetramer:PXLPComplexR-HSA-1625212 (Reactome)
Ceruloplasmin mRNA ProteinM13699 (EMBL)
DARS ProteinP14868 (Uniprot-TrEMBL)
EEF1E1 ProteinO43324 (Uniprot-TrEMBL)
EEFSEC ProteinP57772 (Uniprot-TrEMBL)
EEFSEC:GDPComplexR-HSA-5359051 (Reactome)
EEFSEC:GTPComplexR-HSA-5359045 (Reactome)
EPRS ProteinP07814 (Uniprot-TrEMBL)
FAD MetaboliteCHEBI:16238 (ChEBI)
FAU ProteinP62861 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GNMT ProteinQ14749 (Uniprot-TrEMBL)
GSHMetaboliteCHEBI:16856 (ChEBI)
GSR-2 ProteinP00390-2 (Uniprot-TrEMBL)
GSR-2:FAD dimerComplexR-HSA-71680 (Reactome)
GSSGMetaboliteCHEBI:17858 (ChEBI)
GSSeHMetaboliteCHEBI:64729 (ChEBI)
GSSeSGMetaboliteCHEBI:26634 (ChEBI)
GSSebGalNacMetaboliteCHEBI:77008 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
Gly MetaboliteCHEBI:57305 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
H2SeMetaboliteCHEBI:16503 (ChEBI)
H2SeO4MetaboliteCHEBI:18170 (ChEBI)
H3PO4MetaboliteCHEBI:26078 (ChEBI)
HNMT ProteinP50135 (Uniprot-TrEMBL)
HSeMTR-HSA-5359039 (Reactome)
Hist MetaboliteCHEBI:18295 (ChEBI)
Hist,NAM,GlyComplexR-ALL-5359033 (Reactome)
IARS ProteinP41252 (Uniprot-TrEMBL)
INMTProteinO95050 (Uniprot-TrEMBL)
K+ MetaboliteCHEBI:29103 (ChEBI)
KARS ProteinQ15046 (Uniprot-TrEMBL)
L-AlaMetaboliteCHEBI:57972 (ChEBI)
L-SerMetaboliteCHEBI:33384 (ChEBI)
LARS ProteinQ9P2J5 (Uniprot-TrEMBL)
MARS ProteinP56192 (Uniprot-TrEMBL)
MAT1A ProteinQ00266 (Uniprot-TrEMBL)
MAT1A multimersComplexR-HSA-174383 (Reactome)
MNA MetaboliteCHEBI:16797 (ChEBI)
MSDMR-HSA-5357666 (Reactome)
Me2SeMetaboliteCHEBI:4610 (ChEBI)
Me3Se+MetaboliteCHEBI:77058 (ChEBI)
MeHist MetaboliteCHEBI:29009 (ChEBI)
MeHist,N1MNA,MeGlyComplexR-ALL-5359014 (Reactome)
MeOHMetaboliteCHEBI:17790 (ChEBI)
MeSeHMetaboliteCHEBI:64685 (ChEBI)
MeSeHMTR-HSA-5359068 (Reactome)
MeSeO2HMetaboliteCHEBI:77012 (ChEBI)
MeSeOHMetaboliteCHEBI:77062 (ChEBI)
MeSebGalNacMetaboliteCHEBI:77010 (ChEBI)
MeSecMetaboliteCHEBI:27812 (ChEBI)
Met-tRNAi R-ALL-72393 (Reactome)
MetTrans(1)ComplexR-HSA-5359013 (Reactome)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NAM MetaboliteCHEBI:17154 (ChEBI)
NH3MetaboliteCHEBI:16134 (ChEBI)
NNMT ProteinP40261 (Uniprot-TrEMBL)
PAPMetaboliteCHEBI:17985 (ChEBI)
PAPSS1 ProteinO43252 (Uniprot-TrEMBL)
PAPSS1,2ComplexR-HSA-174400 (Reactome)
PAPSS2 ProteinO95340 (Uniprot-TrEMBL)
PAPSeMetaboliteCHEBI:28450 (ChEBI)
PAPSeRR-HSA-5359054 (Reactome)
PPiMetaboliteCHEBI:29888 (ChEBI)
PSTK ProteinQ8IV42 (Uniprot-TrEMBL)
PSTK:Mg2+ComplexR-HSA-5359062 (Reactome)
PXLP MetaboliteCHEBI:18405 (ChEBI)
PXLP-CBS ProteinP35520 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
QARS ProteinP47897 (Uniprot-TrEMBL)
RARS ProteinP54136 (Uniprot-TrEMBL)
RPL10 ProteinP27635 (Uniprot-TrEMBL)
RPL10A ProteinP62906 (Uniprot-TrEMBL)
RPL10L ProteinQ96L21 (Uniprot-TrEMBL)
RPL11 ProteinP62913 (Uniprot-TrEMBL)
RPL12 ProteinP30050 (Uniprot-TrEMBL)
RPL13 ProteinP26373 (Uniprot-TrEMBL)
RPL13A ProteinP40429 (Uniprot-TrEMBL)
RPL14 ProteinP50914 (Uniprot-TrEMBL)
RPL15 ProteinP61313 (Uniprot-TrEMBL)
RPL17 ProteinP18621 (Uniprot-TrEMBL)
RPL18 ProteinQ07020 (Uniprot-TrEMBL)
RPL18A ProteinQ02543 (Uniprot-TrEMBL)
RPL19 ProteinP84098 (Uniprot-TrEMBL)
RPL21 ProteinP46778 (Uniprot-TrEMBL)
RPL22 ProteinP35268 (Uniprot-TrEMBL)
RPL22L1 ProteinQ6P5R6 (Uniprot-TrEMBL)
RPL23 ProteinP62829 (Uniprot-TrEMBL)
RPL23A ProteinP62750 (Uniprot-TrEMBL)
RPL24 ProteinP83731 (Uniprot-TrEMBL)
RPL26 ProteinP61254 (Uniprot-TrEMBL)
RPL26L1 ProteinQ9UNX3 (Uniprot-TrEMBL)
RPL27 ProteinP61353 (Uniprot-TrEMBL)
RPL27A ProteinP46776 (Uniprot-TrEMBL)
RPL28 ProteinP46779 (Uniprot-TrEMBL)
RPL29 ProteinP47914 (Uniprot-TrEMBL)
RPL3 ProteinP39023 (Uniprot-TrEMBL)
RPL30 ProteinP62888 (Uniprot-TrEMBL)
RPL31 ProteinP62899 (Uniprot-TrEMBL)
RPL32 ProteinP62910 (Uniprot-TrEMBL)
RPL34 ProteinP49207 (Uniprot-TrEMBL)
RPL35 ProteinP42766 (Uniprot-TrEMBL)
RPL35A ProteinP18077 (Uniprot-TrEMBL)
RPL36 ProteinQ9Y3U8 (Uniprot-TrEMBL)
RPL36A ProteinP83881 (Uniprot-TrEMBL)
RPL36AL ProteinQ969Q0 (Uniprot-TrEMBL)
RPL37 ProteinP61927 (Uniprot-TrEMBL)
RPL37A ProteinP61513 (Uniprot-TrEMBL)
RPL38 ProteinP63173 (Uniprot-TrEMBL)
RPL39 ProteinP62891 (Uniprot-TrEMBL)
RPL39L ProteinQ96EH5 (Uniprot-TrEMBL)
RPL3L ProteinQ92901 (Uniprot-TrEMBL)
RPL4 ProteinP36578 (Uniprot-TrEMBL)
RPL40 ProteinP62987 (Uniprot-TrEMBL)
RPL41 ProteinP62945 (Uniprot-TrEMBL)
RPL5 ProteinP46777 (Uniprot-TrEMBL)
RPL6 ProteinQ02878 (Uniprot-TrEMBL)
RPL7 ProteinP18124 (Uniprot-TrEMBL)
RPL7A ProteinP62424 (Uniprot-TrEMBL)
RPL8 ProteinP62917 (Uniprot-TrEMBL)
RPL9 ProteinP32969 (Uniprot-TrEMBL)
RPLP0 ProteinP05388 (Uniprot-TrEMBL)
RPLP1 ProteinP05386 (Uniprot-TrEMBL)
RPLP2 ProteinP05387 (Uniprot-TrEMBL)
RPS10 ProteinP46783 (Uniprot-TrEMBL)
RPS11 ProteinP62280 (Uniprot-TrEMBL)
RPS12 ProteinP25398 (Uniprot-TrEMBL)
RPS13 ProteinP62277 (Uniprot-TrEMBL)
RPS14 ProteinP62263 (Uniprot-TrEMBL)
RPS15 ProteinP62841 (Uniprot-TrEMBL)
RPS15A ProteinP62244 (Uniprot-TrEMBL)
RPS16 ProteinP62249 (Uniprot-TrEMBL)
RPS17 ProteinP08708 (Uniprot-TrEMBL)
RPS18 ProteinP62269 (Uniprot-TrEMBL)
RPS19 ProteinP39019 (Uniprot-TrEMBL)
RPS2 ProteinP15880 (Uniprot-TrEMBL)
RPS20 ProteinP60866 (Uniprot-TrEMBL)
RPS21 ProteinP63220 (Uniprot-TrEMBL)
RPS23 ProteinP62266 (Uniprot-TrEMBL)
RPS24 ProteinP62847 (Uniprot-TrEMBL)
RPS25 ProteinP62851 (Uniprot-TrEMBL)
RPS26 ProteinP62854 (Uniprot-TrEMBL)
RPS27 ProteinP42677 (Uniprot-TrEMBL)
RPS27A(77-156) ProteinP62979 (Uniprot-TrEMBL)
RPS27L ProteinQ71UM5 (Uniprot-TrEMBL)
RPS28 ProteinP62857 (Uniprot-TrEMBL)
RPS29 ProteinP62273 (Uniprot-TrEMBL)
RPS3 ProteinP23396 (Uniprot-TrEMBL)
RPS3A ProteinP61247 (Uniprot-TrEMBL)
RPS4X ProteinP62701 (Uniprot-TrEMBL)
RPS4Y1 ProteinP22090 (Uniprot-TrEMBL)
RPS4Y2 ProteinQ8TD47 (Uniprot-TrEMBL)
RPS5 ProteinP46782 (Uniprot-TrEMBL)
RPS6 ProteinP62753 (Uniprot-TrEMBL)
RPS7 ProteinP62081 (Uniprot-TrEMBL)
RPS8 ProteinP62241 (Uniprot-TrEMBL)
RPS9 ProteinP46781 (Uniprot-TrEMBL)
RPSA ProteinP08865 (Uniprot-TrEMBL)
SARC MetaboliteCHEBI:15611 (ChEBI)
SARS ProteinP49591 (Uniprot-TrEMBL)
SARS dimerComplexR-HSA-379557 (Reactome)
SCLY ProteinQ96I15 (Uniprot-TrEMBL)
SCLY dimer:PXLPComplexR-HSA-5359018 (Reactome)
SECISBP2 ProteinQ96T21 (Uniprot-TrEMBL)
SECISBP2ProteinQ96T21 (Uniprot-TrEMBL)
SELPMetaboliteCHEBI:16144 (ChEBI)
SEPHS2ProteinQ99611 (Uniprot-TrEMBL)
SEPSECS tetramer:PXLPComplexR-HSA-5357724 (Reactome)
SEPSECS ProteinQ9HD40 (Uniprot-TrEMBL)
SeCystaMetaboliteCHEBI:27760 (ChEBI)
SeHCysMetaboliteCHEBI:9096 (ChEBI)
SeMet-tRNA(Met)R-HSA-5357731 (Reactome)
SeMetMetaboliteCHEBI:30021 (ChEBI)
SeO3(2-)MetaboliteCHEBI:18212 (ChEBI)
Sec MetaboliteCHEBI:16633 (ChEBI)
Sec-tRNA(Sec) R-HSA-5357708 (Reactome)
Sec-tRNA(Sec):EEFSEC:GTPComplexR-HSA-5359036 (Reactome)
Sec-tRNA(Sec)R-HSA-5357708 (Reactome)
SecMetaboliteCHEBI:16633 (ChEBI)
Sep-tRNA(Sec)R-HSA-5357712 (Reactome)
Ser-tRNA(Sec)R-HSA-5357730 (Reactome)
TNXRD1:FAD dimerComplexR-HSA-73532 (Reactome)
TXNRD1 ProteinQ16881 (Uniprot-TrEMBL)
acceptorR-ALL-5359011 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
ComplexR-HSA-379688 (Reactome)
bGalNAc derivativeMetaboliteCHEBI:17806 (ChEBI)
bGalNAcMetaboliteCHEBI:28497 (ChEBI)
heme MetaboliteCHEBI:17627 (ChEBI)
pyruvic acidMetaboliteCHEBI:32816 (ChEBI)
reduced acceptorR-ALL-5359016 (Reactome)
tRNA(Met)R-HSA-379742 (Reactome)
tRNA(Sec)R-HSA-5357732 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
2-acetamidoglucalArrowR-HSA-5333612 (Reactome)
2OBUTAArrowR-HSA-2408537 (Reactome)
2OBUTAArrowR-HSA-2408543 (Reactome)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTPArrowR-HSA-2408529 (Reactome)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTPR-HSA-5333615 (Reactome)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTPmim-catalysisR-HSA-5333615 (Reactome)
80S:Met-tRNAi:mRNA:SECISBP2:SecArrowR-HSA-5333615 (Reactome)
80S:Met-tRNAi:mRNAR-HSA-2408529 (Reactome)
ADPArrowR-HSA-2408507 (Reactome)
ADPArrowR-HSA-2408540 (Reactome)
AHCYmim-catalysisR-HSA-2408532 (Reactome)
AMPArrowR-HSA-2408526 (Reactome)
AMPArrowR-HSA-2408546 (Reactome)
AMPArrowR-HSA-8959510 (Reactome)
APSeArrowR-HSA-2408525 (Reactome)
APSeR-HSA-2408540 (Reactome)
ATPR-HSA-2408507 (Reactome)
ATPR-HSA-2408525 (Reactome)
ATPR-HSA-2408526 (Reactome)
ATPR-HSA-2408540 (Reactome)
ATPR-HSA-2408546 (Reactome)
ATPR-HSA-2408551 (Reactome)
ATPR-HSA-8959510 (Reactome)
Ade-RibArrowR-HSA-2408532 (Reactome)
AdeSeHCysArrowR-HSA-2408544 (Reactome)
AdeSeHCysR-HSA-2408532 (Reactome)
AdoHcyArrowR-HSA-2408536 (Reactome)
AdoHcyArrowR-HSA-2408541 (Reactome)
AdoHcyArrowR-HSA-2408554 (Reactome)
AdoHcyArrowR-HSA-5333608 (Reactome)
AdoMetR-HSA-2408536 (Reactome)
AdoMetR-HSA-2408541 (Reactome)
AdoMetR-HSA-2408554 (Reactome)
AdoMetR-HSA-5333608 (Reactome)
AdoSeMetArrowR-HSA-2408551 (Reactome)
AdoSeMetR-HSA-2408544 (Reactome)
CBS tetramermim-catalysisR-HSA-2408559 (Reactome)
CTH tetramer:PXLPmim-catalysisR-HSA-2408537 (Reactome)
CTH tetramer:PXLPmim-catalysisR-HSA-2408539 (Reactome)
CTH tetramer:PXLPmim-catalysisR-HSA-2408543 (Reactome)
EEFSEC:GDPArrowR-HSA-5333615 (Reactome)
EEFSEC:GTPR-HSA-2408509 (Reactome)
GSHArrowR-HSA-2408542 (Reactome)
GSHArrowR-HSA-5333608 (Reactome)
GSHR-HSA-2408500 (Reactome)
GSHR-HSA-2408556 (Reactome)
GSR-2:FAD dimermim-catalysisR-HSA-2408542 (Reactome)
GSSGArrowR-HSA-2408500 (Reactome)
GSSGArrowR-HSA-2408556 (Reactome)
GSSeHArrowR-HSA-2408542 (Reactome)
GSSeHR-HSA-2408500 (Reactome)
GSSeHR-HSA-5333607 (Reactome)
GSSeSGArrowR-HSA-2408556 (Reactome)
GSSeSGR-HSA-2408542 (Reactome)
GSSebGalNacArrowR-HSA-5333607 (Reactome)
GSSebGalNacR-HSA-5333608 (Reactome)
H+ArrowR-HSA-8959510 (Reactome)
H+R-HSA-2408542 (Reactome)
H+R-HSA-2408548 (Reactome)
H+R-HSA-2408556 (Reactome)
H+R-HSA-2408558 (Reactome)
H+R-HSA-5263614 (Reactome)
H+R-HSA-5263616 (Reactome)
H2OArrowR-HSA-2408548 (Reactome)
H2OArrowR-HSA-2408556 (Reactome)
H2OArrowR-HSA-2408558 (Reactome)
H2OArrowR-HSA-2408559 (Reactome)
H2OArrowR-HSA-5263614 (Reactome)
H2OArrowR-HSA-5263616 (Reactome)
H2OR-HSA-2408530 (Reactome)
H2OR-HSA-2408532 (Reactome)
H2OR-HSA-2408537 (Reactome)
H2OR-HSA-2408539 (Reactome)
H2OR-HSA-2408543 (Reactome)
H2OR-HSA-2408551 (Reactome)
H2OR-HSA-2408555 (Reactome)
H2OR-HSA-5333609 (Reactome)
H2OR-HSA-5333615 (Reactome)
H2OR-HSA-8959510 (Reactome)
H2SeArrowR-HSA-2408500 (Reactome)
H2SeArrowR-HSA-2408524 (Reactome)
H2SeArrowR-HSA-2408530 (Reactome)
H2SeArrowR-HSA-2408558 (Reactome)
H2SeO4R-HSA-2408525 (Reactome)
H2SeR-HSA-2408536 (Reactome)
H2SeR-HSA-8959510 (Reactome)
H3PO4ArrowR-HSA-2408555 (Reactome)
HSeMTmim-catalysisR-HSA-2408536 (Reactome)
Hist,NAM,GlyR-HSA-2408544 (Reactome)
INMTmim-catalysisR-HSA-2408554 (Reactome)
L-AlaArrowR-HSA-2408524 (Reactome)
L-SerR-HSA-2408526 (Reactome)
L-SerR-HSA-2408559 (Reactome)
MAT1A multimersmim-catalysisR-HSA-2408551 (Reactome)
MSDMmim-catalysisR-HSA-2408530 (Reactome)
Me2SeArrowR-HSA-2408541 (Reactome)
Me2SeR-HSA-2408554 (Reactome)
Me3Se+ArrowR-HSA-2408554 (Reactome)
MeHist,N1MNA,MeGlyArrowR-HSA-2408544 (Reactome)
MeOHArrowR-HSA-2408530 (Reactome)
MeSeHArrowR-HSA-2408536 (Reactome)
MeSeHArrowR-HSA-2408537 (Reactome)
MeSeHArrowR-HSA-2408539 (Reactome)
MeSeHArrowR-HSA-5263614 (Reactome)
MeSeHArrowR-HSA-5333609 (Reactome)
MeSeHMTmim-catalysisR-HSA-2408541 (Reactome)
MeSeHR-HSA-2408530 (Reactome)
MeSeHR-HSA-2408541 (Reactome)
MeSeO2HArrowR-HSA-5333612 (Reactome)
MeSeO2HR-HSA-5263616 (Reactome)
MeSeOHArrowR-HSA-5263616 (Reactome)
MeSeOHR-HSA-5263614 (Reactome)
MeSebGalNacArrowR-HSA-5333608 (Reactome)
MeSebGalNacR-HSA-5333609 (Reactome)
MeSebGalNacR-HSA-5333612 (Reactome)
MeSecR-HSA-2408539 (Reactome)
MetTrans(1)mim-catalysisR-HSA-2408544 (Reactome)
NADP+ArrowR-HSA-2408542 (Reactome)
NADP+ArrowR-HSA-2408548 (Reactome)
NADP+ArrowR-HSA-2408558 (Reactome)
NADP+ArrowR-HSA-5263614 (Reactome)
NADP+ArrowR-HSA-5263616 (Reactome)
NADPHR-HSA-2408542 (Reactome)
NADPHR-HSA-2408548 (Reactome)
NADPHR-HSA-2408558 (Reactome)
NADPHR-HSA-5263614 (Reactome)
NADPHR-HSA-5263616 (Reactome)
NH3ArrowR-HSA-2408537 (Reactome)
NH3ArrowR-HSA-2408539 (Reactome)
NH3ArrowR-HSA-2408543 (Reactome)
PAPArrowR-HSA-2408548 (Reactome)
PAPSS1,2mim-catalysisR-HSA-2408525 (Reactome)
PAPSS1,2mim-catalysisR-HSA-2408540 (Reactome)
PAPSeArrowR-HSA-2408540 (Reactome)
PAPSeR-HSA-2408548 (Reactome)
PAPSeRmim-catalysisR-HSA-2408548 (Reactome)
PPiArrowR-HSA-2408525 (Reactome)
PPiArrowR-HSA-2408526 (Reactome)
PPiArrowR-HSA-2408546 (Reactome)
PPiArrowR-HSA-2408551 (Reactome)
PSTK:Mg2+mim-catalysisR-HSA-2408507 (Reactome)
PiArrowR-HSA-2408551 (Reactome)
PiArrowR-HSA-5333615 (Reactome)
PiArrowR-HSA-8959510 (Reactome)
R-HSA-2408500 (Reactome) Gluthathioselenol (GSSeH) and reduced glutathione (GSH) condense to form hydrogen selenide (H2Se) and glutathione disulfide (GSSG). This reaction is inferred from the event in rat (Bjornstedt et al. 1992).
R-HSA-2408507 (Reactome) L-seryl-tRNA(Sec) kinase (PSTK) phosphorylates the serylated transfer RNA (tRNA) for Sec (Ser-tRNASec) to form Sep-tRNASec in the presence of ATP and Mg2+. PSTK exhibits a strict selectivity for Ser-tRNASec. It does not phosphorylate free Ser or Ser attached to its cognate tRNASer. This reaction involving PSTK is inferred from the equivalent reaction in mouse.
R-HSA-2408509 (Reactome) The final product, selenocysteinyl transfer RNA (tRNA) for Sec (Sec-tRNASec) binds to selenocysteine-specific elongation factor (EEFSEC) aka SelB complexed with GTP. This complex is now ready to be delivered to the 80S ribosome. This reaction is inferred from the equivalent reaction in mouse.
R-HSA-2408524 (Reactome) Selenocysteine lyase (SCLY) homodimer is involved in the reduction of selenocysteine (Sec) to hydrogen selenide (H2Se) and alanine (Ala) (Daher and Van Lente 1992).
R-HSA-2408525 (Reactome) Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthases 1 and 2 (PAPSS1,2) (Venkatachalam et al. 1998, Xu et al. 2000) are involved in transforming adenosine triphosphate (ATP) and selenic acid (H2SeO4) into adenylylselenate (APSe) and diphosphate via its ATP sulphurylase domain. This reaction is inferred from the event in rat (Yu et al. 1989).
R-HSA-2408526 (Reactome) The synthetic cycle of selenocysteine (Sec) synthesis starts with misacylation (serylation) of the cognate transfer RNA (tRNA) for Sec, tRNASec, with serine (Ser) by Serine--tRNA ligase (SARS) homodimer. The structural homology of tRNASec and tRNASer enables SARS to form Ser-tRNASec (Vincent et al. 1997, Amberg et al. 1996, Heckl et al. 1998).
R-HSA-2408529 (Reactome) The complex consisting of selenocysteinyl (Sec) transfer RNA (tRNA) for Sec (Sec-tRNASec), selenocysteine-specific elongation factor (EEFSEC) aka SelB, selenocysteine insertion sequence-binding protein 2 (SECISBP2) aka SBP2 and GTP interacts with the 80S ribosomal protein complex (80S:Met-tRNAi:mRNA). This reaction is inferred from events occurring in rats.
R-HSA-2408530 (Reactome) A yet to be identified enzyme with methylselenol demethylase (MSDM) activity is involved in the hydrolysis of methylselenol aka methaneselenol (MeSeH) into hydrogen selenide (H2Se) and methanol. This reaction is inferred from the event in rat (Suzuki et al. 2007, Ohta and Suzuki 2008).
R-HSA-2408532 (Reactome) Adenosylhomocysteinase (AHCY) is involved in the hydrolysis of adenosylselenohomocysteine (AdeSeHCys) into adenosine and selenohomocysteine (SeHCys). This reaction is inferred from the event in rat involving the protein adenosylhomocysteinase (Ahcy) (Kajander et al. 1991, Kajander and Raina 1981).
R-HSA-2408536 (Reactome) A yet to be identified enzyme with hydrogen selenide methyltransferase (HSeMT) activity is involved in the methylation of hydrogen selenide (H2Se) into methylselenol aka methaneselenol (MeSeH) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy). This reaction is inferred from the event in rat (Ohta and Suzuki 2008, Hsieh and Ganther 1977).
R-HSA-2408537 (Reactome) Excess selenomethionine (SeMet) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and 2-oxobutanoic acid. This reaction is inferred from the event in mouse involving the protein cystathionine gamma-lyase (Cth) (Okuno et al. 2001, Okuno et al. 2005, Okuno et al. 2006).
R-HSA-2408539 (Reactome) Methylselenocysteine (MeSec) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and pyruvic acid. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) (Pinto et al. 2011, Suzuki et al. 2007).
R-HSA-2408540 (Reactome) Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthases 1 and 2 (PAPSS1,2) (Venkatachalam et al. 1998, Xu et al. 2000) are involved in phosphorylating adenylylselenate (APSe) into 3'-phosphoadenylyl selenate (PAPSe) via its APS kinase domain. This reaction is inferred from the event in Penicillium chrysogenum involving APS kinase (Kaps) (Yu et al. 1989).
R-HSA-2408541 (Reactome) A yet to be identified enzyme with methylselenol methyltransferase (MeSeHMT) activity is involved in the methylation of methylselenol aka methaneselenol (MeSeH) into dimethyl selenide (Me2Se) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy). This reaction is inferred from the event in rat (Ohta and Suzuki 2008, Hsieh and Ganther 1977).
R-HSA-2408542 (Reactome) Glutathione reductase (GSR) homodimer is involved in the reduction of selenodiglutathione (GSSeSG) into gluthathioselenol (GSSeH) and reduced glutathione (GSH). This reaction is inferred from the event in rat (Bjornstedt et al. 1992).
R-HSA-2408543 (Reactome) Cystathionine gamma-lyase (CTH) homotetramer is involved in the hydrolysis of selenocystathionine (SeCysta) into selenocysteine (Sec), ammonia and 2-oxobutanoic acid by an alpha,gamma-elimination reaction. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) homotetramer (Esaki et al. 1981).
R-HSA-2408544 (Reactome) A set of methyltransferases (MetTrans(1)) consisting of the proteins histamine-N-methyltransferase (HNMT), glycine-N-methyltransferase (GNMT), and nicotinamide-N-methyltransferase (NNMT) remove a methyl group from adenosylselenomethionine (AdoSeMet) to leave adenosylselenohomocysteine (AdeSeHCys). This reaction is inferred from the event in rat involving the set of methyltransferases (MetTrans(2)) consisting of the proteins histamine-N-methyltransferase (Hnmt), glycine-N-methyltransferase (Gnmt), and nicotinamide-N-methyltransferase (Nnmt) (Kajander et al. 1991).
R-HSA-2408546 (Reactome) The multisynthetase complex consists of bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. It is involved in the selenomethionylation of tRNA(Met) into selenomethionyl-tRNA(Met) (SeMet-tRNA(Met)). This reaction is inferred from the event in mung bean (Burnell 1981) and in wheat germ (Eustice et al. 1981).
R-HSA-2408548 (Reactome) A yet to be identified enzyme with 3'-phosphoadenylyl selenate reductase (PAPSeR) activity is involved in the reduction of 3'-phosphoadenylyl selenate (PAPSe) into selenite (SeO3(2-)) and adenosine 3',5'-bismonophosphate (PAP). This reaction is inferred from the event in yeast (Banszky et al. 2003).
R-HSA-2408551 (Reactome) Methionine adenosyltransferases (MAT multimers) consisting of a S-adenosylmethionine synthase isoform type-1 (MAT1A) homodimer and a MAT1A: S-adenosylmethionine synthase isoform type-2 (MAT2A) heterodimer are responsible for the conversion of selenomethionine (SeMet) and ATP into Se-adenosylselenomethionine (AdoSeMet), orthophosphate (Pi), and diphosphate (PPi) (Kajander et al. 1990).
R-HSA-2408554 (Reactome) Indolethylamine N-methyltransferase (INMT) is involved in the methylation of dimethyl selenide (Me2Se) into trimethylselenonium (Me3Se+) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy). This reaction is inferred from the event in mouse (Mozier et al. 1988).
R-HSA-2408555 (Reactome) O-phosphoseryl-tRNA(Sec) selenium transferase (SEPSECS) tetramer catalyses the transformation of phosphoserine (Sep) into selenocysteine (Sec) by using selenophosphate (SELP) as a selenium donor to convert the phosphoserylated transfer RNA (tRNA) for Sec (Sep-tRNASec) into Sec-tRNASec (Palioura et al. 2009, Yuan et al. 2006).
R-HSA-2408556 (Reactome) Selenite (SeO3(2-)) and reduced glutathione (GSH) spontaneously react to form selenodiglutathione (GSSeSG) and glutathione disulfide (GSSG). This has been proposed to be the major form of entry of selenium compounds into metabolism. This reaction is inferred from the event in rat (Bjornstedt et al. 1992).
R-HSA-2408558 (Reactome) Thioredoxin reductase 1 (TXNRD1) homodimer (Sun et al. 1999) is involved in the reduction of selenite (SeO3(2-)) into hydrogen selenide (H2Se). This reaction is inferred from the event in cow (Kumar et al. 1992).
R-HSA-2408559 (Reactome) Cystathionine beta-synthase (CBS) is involved in the dehydration of selenohomocysteine (SeHCys) and serine that produces selenocystathionine (SeCysta). This reaction is inferred from the event in rat involving the protein cystathionine beta-synthase (Cbs) (Esaki et al. 1981).
R-HSA-5263614 (Reactome) Thioredoxin reductase 1 (TXNRD1) homodimer is involved in the reduction of methylselenenic acid (MeSeOH) into methylselenol (MeSeH) (Gromer and Gross 2002).
R-HSA-5263616 (Reactome) Thioredoxin reductase 1 (TXNRD1) homodimer is involved in the reduction of methylseleninic acid (MeSeO2H) into methylselenenic acid (MeSeOH) (Gromer and Gross 2002).
R-HSA-5333607 (Reactome) 1beta-methylseleno-N-acetyl-D-galactosamine (bGalNAc ) derivative combines with glutathioselenol (GSSeH) to form 1beta-glutathionylseleno-N-acetyl-D-galactosamine (GSSebGalNac) aka selenosugar A by an unknown mechanism. The actual enzyme or enzymes involved have yet to be identified. This reaction is inferred from the event in rat (Kobayashi et al. 2002).
R-HSA-5333608 (Reactome) 1beta-glutathionylseleno-N-acetyl-D-galactosamine (GSSebGalNac) aka selenosugar A is converted into 1beta-methylseleno-N-acetyl-D-galactosamine (MeSebGalNac) aka selenosugar B by an unknown mechanism. The actual enzyme or enzymes involved have yet to be identified. This reaction is inferred from the event in rat (Kobayashi et al. 2002).
R-HSA-5333609 (Reactome) 1beta-methylseleno-N-acetyl-D-galactosamine (MeSebGalNac) aka selenosugar B is hydrolysed to methylselenol (MeSeH) and N-acetyl-beta-D-galactosamine (bGalNac) by an unknown mechanism. The actual enzyme or enzymes involved have yet to be identified. This reaction is inferred from the event in rat (Suzuki et al. 2006).
R-HSA-5333612 (Reactome) 1beta-methylseleno-N-acetyl-D-galactosamine (MeSebGalNac) aka selenosugar B is oxidatively cleaved to methylseleninic acid (MeSeO2H) and 2-acetamidoglucal by an unknown mechanism. The actual enzyme or enzymes involved have yet to be identified. This reaction is inferred from the event in rat (Suzuki et al. 2006).
R-HSA-5333615 (Reactome) The complex consisting of selenocysteinyl (Sec) transfer RNA (tRNA) for Sec (Sec-tRNASec), selenocysteine-specific elongation factor (EEFSEC) aka SelB, selenocysteine insertion sequence-binding protein 2 (SECISBP2) aka SBP2 and GTP interacts with the 80S ribosomal protein complex (80S:Met-tRNAi:mRNA). This triggers the hydrolysis of GTP (to GDP) by EEFSEC and delivery of Sec-tRNASec to the ribosomal A site. Before the Sec residue is inserted into the nascent polypeptide chain, EEFSEC:GDP is released. This reaction is inferred from events occurring in rats.
R-HSA-8959510 (Reactome) Selenoproteins are proteins that incorporate the nonstandard amino acid selenocysteine (Sec) in response to the UGA codon. Sec is synthesised in several steps from hydrogen selenide (H2Se), an intermediate formed from dietary sources of selenium. In the first step, cytosolic selenide water dikinase 2 (SEPHS2 aka SPS2) mediates the phosphorylation of H2Se using ATP as the phosphate donor, forming selenophosphate (SELP) (Tamura et al. 2004).
SARS dimermim-catalysisR-HSA-2408526 (Reactome)
SCLY dimer:PXLPmim-catalysisR-HSA-2408524 (Reactome)
SECISBP2R-HSA-2408529 (Reactome)
SELPArrowR-HSA-8959510 (Reactome)
SELPR-HSA-2408555 (Reactome)
SEPHS2mim-catalysisR-HSA-8959510 (Reactome)
SEPSECS tetramer:PXLPmim-catalysisR-HSA-2408555 (Reactome)
SeCystaArrowR-HSA-2408559 (Reactome)
SeCystaR-HSA-2408543 (Reactome)
SeHCysArrowR-HSA-2408532 (Reactome)
SeHCysR-HSA-2408559 (Reactome)
SeMet-tRNA(Met)ArrowR-HSA-2408546 (Reactome)
SeMetR-HSA-2408537 (Reactome)
SeMetR-HSA-2408546 (Reactome)
SeMetR-HSA-2408551 (Reactome)
SeO3(2-)ArrowR-HSA-2408548 (Reactome)
SeO3(2-)R-HSA-2408556 (Reactome)
SeO3(2-)R-HSA-2408558 (Reactome)
Sec-tRNA(Sec):EEFSEC:GTPArrowR-HSA-2408509 (Reactome)
Sec-tRNA(Sec):EEFSEC:GTPR-HSA-2408529 (Reactome)
Sec-tRNA(Sec)ArrowR-HSA-2408555 (Reactome)
Sec-tRNA(Sec)R-HSA-2408509 (Reactome)
SecArrowR-HSA-2408543 (Reactome)
SecR-HSA-2408524 (Reactome)
Sep-tRNA(Sec)ArrowR-HSA-2408507 (Reactome)
Sep-tRNA(Sec)R-HSA-2408555 (Reactome)
Ser-tRNA(Sec)ArrowR-HSA-2408526 (Reactome)
Ser-tRNA(Sec)R-HSA-2408507 (Reactome)
TNXRD1:FAD dimermim-catalysisR-HSA-2408558 (Reactome)
TNXRD1:FAD dimermim-catalysisR-HSA-5263614 (Reactome)
TNXRD1:FAD dimermim-catalysisR-HSA-5263616 (Reactome)
acceptorArrowR-HSA-2408524 (Reactome)
aminoacyl-tRNA

synthetase

multienzyme complex
mim-catalysisR-HSA-2408546 (Reactome)
bGalNAc derivativeR-HSA-5333607 (Reactome)
bGalNAcArrowR-HSA-5333609 (Reactome)
pyruvic acidArrowR-HSA-2408539 (Reactome)
reduced acceptorR-HSA-2408524 (Reactome)
tRNA(Met)R-HSA-2408546 (Reactome)
tRNA(Sec)ArrowR-HSA-5333615 (Reactome)
tRNA(Sec)R-HSA-2408526 (Reactome)
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