Felbamate metabolism (Homo sapiens)

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Description

CYP metabolism of felbamate, with the metabolites 2-hydroxyfelbamate, p-hydroxyfelbamate, and 3-Hydroxy-2-phenylpropylcarbamate. The last further metabolizes to 3-carbamoyl-2-phenylpropionaldehyde, atropaldehyde, and 3-carbamoyl-2-phenylpropionic acid.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Husain Z, Pinto C, Sofia RD, Yunis EJ; ''Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways.''; Epilepsy Res, 2002 PubMed Europe PMC Scholia
  2. Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH; ''Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.''; Clin Pharmacokinet, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139962view10:38, 13 July 2025EgonwModified description
117724view12:34, 22 May 2021EweitzModified title
106726view13:20, 17 September 2019MaintBotHMDB identifier normalization
92386view18:22, 31 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
88575view19:03, 11 August 2016Mkutmonfix unconnected lines
76465view19:15, 9 July 2014KhanspersOntology Term : 'nervous system drug pathway' added !
75464view13:15, 31 May 2014EgonwAdded a few more steps.
75435view15:33, 30 May 2014EgonwAdded the third known metabolite.
75434view15:07, 30 May 2014EgonwAdded a literature references, supporting KEGG's CYP3A4, rather then DrugBank's CYP3A7.
75433view14:32, 30 May 2014EgonwModified description
75432view14:31, 30 May 2014EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1.1.1.1Protein1.1.1.1 (Enzyme Nomenclature)
1.2.1.5Protein1.2.1.5 (Enzyme Nomenclature)
2-hydroxyfelbamateMetabolite8575477 (Chemspider)
3-Hydroxy-2-phenylpropyl carbamateMetabolite184751 (Chemspider)
3-carbamoyl-2-phenyl propionaldehydeMetabolite21350391 (PubChem-compound)
3-carbamoyl-2-phenyl propionic acidMetabolite3025746 (PubChem-compound)
CYP2E1GeneProductENSG00000130649 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
FelbamateMetaboliteHMDB0015084 (HMDB)
atropaldehydeMetabolite10312 (PubChem-compound)
p-hydroxyfelbamateMetabolite8096945 (Chemspider)

Annotated Interactions

No annotated interactions

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