Leukocyte-intrinsic Hippo pathway functions (Homo sapiens)

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1IntracellularVesicleIntegrin trafficking and distributionLeukocyteMyosin IIaImmune-relatedgenesLymphocyte motility, migration,thymic egressYAPintegrinsPYWHAQPPTAZPPYAP1TAZLATS1PLATS2PMOB1PMST1MST2PPSAV1PMOB1PNDR1PNDR2PMST1MST2FOXO6PFOXO4FOXO1PFOXO3PPFOXP3AcFOXP3TEAD1MST1MST2RAPRAPLRac1RAPRAPLRac1Kindlin-3Kindlin-3SKAPADAPMST1MST2RAB13Blimp1T.reg PhenotypeRAB13RAP1RAPLSKAPRAP1RAPLRHOACCR7Lymphocyte polarizationEnhanced BCR humoral responsein B lymphocytesCD19BLIMP1Terminal differentiation/clonalexpansion of CD8+ T cellsMaturation/survival ofT cells in SLORHOAFOXO6FOXO4FOXO1FOXO3Homeostatic maintenanceNORE1BFOXO6FOXO4FOXO1FOXO3miR-21LATS1Cytoarchitecturalintegrity/specificityLPLT.h17/T.reg differentiationof CD4+ T cellsFOXO1FOXO3p38MAPKAntigen cross presentationby APCsKindlin-3Lymphocyte adhesionand extravasationRHOALFA-1LFA-1LFA-1LFA-1LFA-1LFA-1LFA-1FOXP3TEAD2TEAD3TEAD4LFA-1MST1MST2LPLPLFA-1LFA-1LFA-1


Description

The Hippo signaling pathway can regulate T lymphocyte proliferation and survival, giving rise to implications for cancer and immunology.

Solid lines: direct interactions

Dotted lines: indirect (or not fully delineated) mechanisms

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Ontology Terms

 

Bibliography

  1. Taha Z, Janse van Rensburg HJ, Yang X; ''The Hippo Pathway: Immunity and Cancer.''; Cancers (Basel), 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
120673view01:29, 23 December 2021EweitzModified title
104788view23:55, 14 June 2019AriuttaOntology Term : 'immune response pathway' added !
104787view23:53, 14 June 2019AriuttaOntology Term : 'cancer' added !
104786view23:47, 14 June 2019AriuttaOntology Term : 'T cell' added !
104785view23:45, 14 June 2019AriuttaAdd upregulation interactions
104784view23:03, 14 June 2019AriuttaModified description
104783view22:48, 14 June 2019AriuttaAdd a couple more identifiers.
104780view22:46, 14 June 2019AriuttaAdd edge and more identifiers. Improve layout.
104334view14:05, 17 May 2019FehrhartOntology Term : 'leukocyte' added !
103581view16:16, 18 March 2019Elisson nlGene fixed
103433view09:39, 1 March 2019Marvin M2Ontology Term : 'Hippo signaling pathway' added !
103412view17:03, 27 February 2019AriuttaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADAPGeneProduct2533 (Entrez Gene)
BLIMP1GeneProduct639 (Entrez Gene)
Blimp1GeneProduct639 (Entrez Gene)
CCR7GeneProduct1236 (Entrez Gene) CCR7)
CD19GeneProduct930 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene) FOXO
FOXO3GeneProduct2309 (Entrez Gene) FOXO
FOXO4GeneProduct4303 (Entrez Gene) FOXO
FOXO6GeneProduct100132074 (Entrez Gene) FOXO
FOXP3GeneProduct50943 (Entrez Gene) FOXO
Kindlin-3GeneProduct83706 (Entrez Gene)
LATS1GeneProduct9113 (Entrez Gene) LATS1)
LATS2GeneProduct26524 (Entrez Gene)
LFA-1GeneProduct3683 (Entrez Gene)
LPLGeneProduct4023 (Entrez Gene) LPL
Lymphocyte motility, migration, thymic egressPathway
MOB1GeneProduct55233 (Entrez Gene)
MST1GeneProduct4485 (Entrez Gene) MST1/2
MST2GeneProduct6788 (Entrez Gene)
NDR1GeneProduct10397 (Entrez Gene)
NDR2GeneProduct23012 (Entrez Gene)
NORE1BGeneProduct83593 (Entrez Gene)
RAB13GeneProduct5872 (Entrez Gene) Rab13
RAP1GeneProduct5906 (Entrez Gene)
RAPGeneProduct83593 (Entrez Gene)
RAPLGeneProduct83593 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene) RhoA
Rac1GeneProduct5879 (Entrez Gene)
SAV1GeneProduct60485 (Entrez Gene)
SKAPGeneProduct90417 (Entrez Gene)
TAZGeneProduct6901 (Entrez Gene) YAP/TAZ
TEAD1GeneProduct7003 (Entrez Gene)
TEAD2GeneProduct8463 (Entrez Gene)
TEAD3GeneProduct7005 (Entrez Gene)
TEAD4GeneProduct7004 (Entrez Gene)
YAPGeneProduct10413 (Entrez Gene)
YAP1GeneProduct10413 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene) 14-3-3
integrinsGeneProductPF08441 (Pfam)
miR-21GeneProduct406991 (Entrez Gene)
p38MAPKGeneProduct1432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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