Neural crest cell migration in cancer (Homo sapiens)

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1NucleusInvasionIncreased level of EMT markersFOSAKT1EPHB1AKT3ARF1CDH11NGEFRAC1TIAM1RHOAPIK3R6PIK3CGF2RL2MMP9NTRK2PIK3R4KIDINS220PIK3CDJUNTWIST1AKT2MMP8MMP2BDNFTRIOPIK3CBPIK3R5PIK3R3STAT3PIK3CAPCDH11PPAKT3AKT1AKT2PNGFRNGFREPHB2EPHB3EPHB4EPHB6BDNFSTAT3PMMP2TWIST1MMP9RAC1PPAK2PAK3PAK4PAK5PAK6CytokeletonremodelingCytoplasmRAC1PPAK1PNGFRproBDNFNTRK2NTRK2SORT1NGFR-ICD


Description

Neural crest cells migrate and invade as part of normal development, but also as part of neuroblastoma metastasis in cancer. Many of the same growth factors, receptors and signaling pathways are involved. The participation of NTRK2 (TrkB), KIDINS220, and SORT1 (Sortilin) appear to be unique to the cancer signaling case, as well as the role for the intracellular domain fragment of NGFR (NGFR-ICD or p75ICD). Also see the closely related pathway, "Neural crest cells during development" (WP4564).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Wislet S, Vandervelden G, Rogister B; ''From Neural Crest Development to Cancer and Vice Versa: How p75NTRand (Pro)neurotrophins Could Act on Cell Migration and Invasion?''; Front Mol Neurosci, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
124548view04:37, 8 November 2022EweitzModified description
124086view19:43, 17 September 2022AlexanderPicofixed link in description
117804view14:29, 22 May 2021EweitzModified title
108154view10:38, 29 November 2019FehrhartOntology Term : 'cancer' added !
108153view10:38, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
103714view01:31, 29 March 2019AlexanderPicoOntology Term : 'CL:0011012' removed !
103713view01:31, 29 March 2019AlexanderPicoOntology Term : 'migratory neural crest cell' added !
103711view01:30, 29 March 2019AlexanderPicoModified description
103709view01:28, 29 March 2019AlexanderPicoModified description
103708view01:28, 29 March 2019AlexanderPicoOntology Term : 'neuroblastoma' added !
103707view01:27, 29 March 2019AlexanderPicoOntology Term : 'neural crest cell' added !
103706view01:27, 29 March 2019AlexanderPicoOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
103705view01:27, 29 March 2019AlexanderPicoOntology Term : 'signaling pathway' added !
103704view01:27, 29 March 2019AlexanderPicoModified description
103703view01:26, 29 March 2019AlexanderPicoModified description
103702view01:24, 29 March 2019AlexanderPicoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene) AKT
AKT2GeneProduct208 (Entrez Gene) AKT
AKT3GeneProduct10000 (Entrez Gene) AKT
ARF1GeneProduct375 (Entrez Gene)
BDNFGeneProduct627 (Entrez Gene) BDNF
CDH11GeneProduct1009 (Entrez Gene) Cadherin
EPHB1GeneProduct2047 (Entrez Gene) MMP
EPHB2GeneProduct2048 (Entrez Gene) MMP
EPHB3GeneProduct2049 (Entrez Gene) MMP
EPHB4GeneProduct2050 (Entrez Gene) MMP
EPHB6GeneProduct2051 (Entrez Gene) MMP
F2RL2GeneProduct2151 (Entrez Gene) MMP
FOSGeneProduct2353 (Entrez Gene) AP-1
JUNGeneProduct3725 (Entrez Gene) JUN/AP
KIDINS220GeneProduct57498 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene) MMP2
MMP8GeneProduct4317 (Entrez Gene) MMP
MMP9GeneProduct4318 (Entrez Gene) MMP
NGEFGeneProduct25791 (Entrez Gene)
NGFR-ICDGeneProduct4804 (Entrez Gene)
NGFRGeneProduct4804 (Entrez Gene)
NTRK2GeneProduct4915 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
PAK5GeneProduct57144 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene) PI3K
PIK3CBGeneProduct5291 (Entrez Gene) PI3K
PIK3CDGeneProduct5293 (Entrez Gene) PI3K
PIK3CGGeneProduct5294 (Entrez Gene) PI3K
PIK3R3GeneProduct8503 (Entrez Gene) PI3K
PIK3R4GeneProduct30849 (Entrez Gene) PI3K
PIK3R5GeneProduct23533 (Entrez Gene) PI3K
PIK3R6GeneProduct146850 (Entrez Gene) PI3K
RAC1GeneProduct5879 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene) RhoA
SORT1GeneProduct6272 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene) STAT3
TIAM1GeneProduct7074 (Entrez Gene) Tiam
TRIOGeneProduct7204 (Entrez Gene) TRIO
TWIST1GeneProduct7291 (Entrez Gene) Twist1,
proBDNFGeneProduct627 (Entrez Gene) BDNF

Annotated Interactions

No annotated interactions

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