PFAS interaction with liver PPARα receptor leading to hepatocellular adenomas and carcinomas (Homo sapiens)

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Activation PPARα Increase, cell proliferation (hepatocytes)Increase, Phenotypic enzyme activity Increase, hepatocellular adenomas and carcinomas Increase, Clonal Expansion of Altered Hepatic Foci


Description

PFAS interaction with liver PPARalpha receptor leading to carcinomas

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History

CompareRevisionActionTimeUserComment
129411view10:27, 12 April 2024SamBrussNew pathway

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DataNodes

NameTypeDatabase referenceComment
Increase, Clonal Expansion of Altered Hepatic Foci
Increase, cell proliferation (hepatocytes)
Increase, hepatocellular adenomas and carcinomas
Activation PPARα
Increase, Phenotypic enzyme activity

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