lipoprotein metabolism in peripheral tissues (Homo sapiens)
From WikiPathways
Description
This pathway incorporates different lipoprotein classes as well as their subclasses and components. It includes how these particles and their compositions transfer in peripheral tissues and the enzymes that are involved.
Quality Tags
Ontology Terms
Saving...Bibliography
- Nguyen P, Leray V, Diez M, Serisier S, Le Bloc'h J, Siliart B, Dumon H; ''Liver lipid metabolism.''; J Anim Physiol Anim Nutr (Berl), 2008 PubMed Europe PMC Scholia
History
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| APOA1 | Protein | ENSG00000118137 (Ensembl)  | apolipoprotein A-I |
| APOB100 | Protein | 338 (Entrez Gene) | Structure; receptor ligand |
| APOC2 | Protein | ENSG00000234906 (Ensembl) | Lipoprotein lipase activato |
| APOC3 | Protein | ENSG00000110245 (Ensembl) | Hepatic lipase inhibitor |
| APOE | Protein | ENSG00000130203 (Ensembl) | Substrate for LDLr; chylomicron remnant receptor |
| CETP | Protein | ENSG00000087237 (Ensembl) | cholesteryl ester transfer protein, plasma |
| Cholesterol ester | Metabolite | HDL-CE (ChEBI) | |
| Cholesterol ester | Metabolite | IDL-CE (ChEBI) | Cholesterol esters in IDL |
| Cholesterol ester | Metabolite | L-HDL-CE (ChEBI) | Cholesterol esters in large HDL |
| Cholesterol ester | Metabolite | L-LDL-CE (ChEBI) | Cholesterol esters in large LDL |
| Cholesterol ester | Metabolite | L-VLDL-CE (ChEBI) | Cholesterol esters in large VLDL |
| Cholesterol ester | Metabolite | LDL-CE (ChEBI) | |
| Cholesterol ester | Metabolite | M-HDL-CE (ChEBI) | Cholesterol esters in medium HDL |
| Cholesterol ester | Metabolite | M-LDL-CE (ChEBI) | Cholesterol esters in medium LDL |
| Cholesterol ester | Metabolite | M-VLDL-CE (ChEBI) | Cholesterol esters in mdeium VLDL |
| Cholesterol ester | Metabolite | S-HDL-CE (ChEBI) | Cholesterol esters in small HDL |
| Cholesterol ester | Metabolite | S-LDL-CE (ChEBI) | Cholesterol esters in small LDL |
| Cholesterol ester | Metabolite | S-VLDL-CE (ChEBI) | Cholesterol esters in small VLDL |
| Cholesterol ester | Metabolite | VLDL-CE (ChEBI) | |
| Cholesterol ester | Metabolite | XL-HDL-CE (ChEBI) | Cholesterol esters in very large HDL |
| Cholesterol ester | Metabolite | XL-VLDL-CE (ChEBI) | Cholesterol esters in very large VLDL |
| Cholesterol ester | Metabolite | XS-VLDL-CE (ChEBI) | Cholesterol esters in very small VLDL |
| Cholesterol ester | Metabolite | XXL-VLDL-CE (ChEBI) | Cholesterol esters in chylomicrons and extremely large VLDL |
| Chylomicron & XXL VLDL | Pathway | GO:0042627 (GeneOntology) | A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. |
| Free cholesterol | Metabolite | CHEBI:50404 (ChEBI) | |
| Free cholesterol | Metabolite | IDL-FC (ChEBI) | Free cholesterol in IDL |
| Free cholesterol | Metabolite | L-HDL-FC (ChEBI) | Free cholesterol in large HDL |
| Free cholesterol | Metabolite | L-LDL-FC (ChEBI) | Free cholesterol in large LDL |
| Free cholesterol | Metabolite | L-VLDL-FC (ChEBI) | Free cholesterol in large VLDL |
| Free cholesterol | Metabolite | M-HDL-FC (ChEBI) | Free cholesterol in medium HDL |
| Free cholesterol | Metabolite | M-LDL-FC (ChEBI) | Free cholesterol in medium LDL |
| Free cholesterol | Metabolite | M-VLDL-FC (ChEBI) | Free cholesterol in medium VLDL |
| Free cholesterol | Metabolite | S-HDL-FC (ChEBI) | Free cholesterol in very large HDL |
| Free cholesterol | Metabolite | S-LDL-FC (ChEBI) | Free cholesterol in small LDL |
| Free cholesterol | Metabolite | S-VLDL-FC (ChEBI) | Free cholesterol in small VLDL |
| Free cholesterol | Metabolite | XL-HDL-FC (ChEBI) | Free cholesterol in very large HDL |
| Free cholesterol | Metabolite | XL-VLDL-FC (ChEBI) | Free cholesterol in very large VLDL |
| Free cholesterol | Metabolite | XS-VLDL-FC (ChEBI) | Free cholesterol in very small VLDL |
| Free cholesterol | Metabolite | XXL-VLDL-FC (ChEBI) | Free cholesterol in chylomicrons and extremely large VLDL |
| HL | Protein | ENSG00000166035 (Ensembl) | lipase, hepatic |
| IDL | Pathway | GO:0034363 (GeneOntology) | A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL). |
| L HDL | Pathway | GO:0034364 (GeneOntology) | A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. |
| L LDL | Pathway | GO:0034362 (GeneOntology) | A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. |
| L VLDL | Pathway | GO:0034361 (GeneOntology) | A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. |
| LCAT | Protein | ENSG00000213398 (Ensembl) | lecithin-cholesterol acyltransferase |
| LPL | Protein | ENSG00000175445 (Ensembl) | lipoprotein lipase |
| M HDL | Pathway | GO:0034364 (GeneOntology) | A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. |
| M LDL | Pathway | GO:0034362 (GeneOntology) | A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. |
| M VLDL | Pathway | GO:0034361 (GeneOntology) | |
| PLTP | Protein | ENSG00000100979 (Ensembl) | phospholipid transfer protein |
| Phospholipid | Metabolite | HDL-PL (ChEBI) | |
| Phospholipid | Metabolite | IDL-PL (ChEBI) | Phospholipids in IDL |
| Phospholipid | Metabolite | L-HDL-PL (ChEBI) | Phospholipids in large HDL |
| Phospholipid | Metabolite | L-LDL-PL (ChEBI) | Phospholipids in large LDL |
| Phospholipid | Metabolite | L-VLDL-PL (ChEBI) | Phospholipids in large VLDL |
| Phospholipid | Metabolite | LDL-PL (ChEBI) | |
| Phospholipid | Metabolite | M-HDL-PL (ChEBI) | Phospholipids in medium HDL |
| Phospholipid | Metabolite | M-LDL-PL (ChEBI) | Phospholipids in medium LDL |
| Phospholipid | Metabolite | M-VLDL-PL (ChEBI) | Phospholipids in medium VLDL |
| Phospholipid | Metabolite | S-HDL-PL (ChEBI) | Phospholipids in small HDL |
| Phospholipid | Metabolite | S-LDL-PL (ChEBI) | Phospholipids in small LDL |
| Phospholipid | Metabolite | S-VLDL-PL (ChEBI) | Phospholipids in small VLDL |
| Phospholipid | Metabolite | VLDL-PL (ChEBI) | |
| Phospholipid | Metabolite | XL-HDL-PL (ChEBI) | Phospholipids in very large HDL |
| Phospholipid | Metabolite | XL-VLDL-PL (ChEBI) | Phospholipids in very large VLDL |
| Phospholipid | Metabolite | XS-VLDL-PL (ChEBI) | Phospholipids in very small VLDL |
| Phospholipid | Metabolite | XXL-VLDL-PL (ChEBI) | Phospholipids in chylomicrons and extremely large VLDL |
| Phospholipids | Metabolite | CHEBI:16247 (ChEBI) | |
| S HDL | Pathway | GO:0034364 (GeneOntology) | A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. |
| S LDL | Pathway | GO:0034362 (GeneOntology) | A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. |
| S VLDL | Pathway | GO:0034361 (GeneOntology) | A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. |
| Triglyceride | Metabolite | HDL-TG (ChEBI) | |
| Triglyceride | Metabolite | IDL-TG (ChEBI) | Triglycerides in IDL |
| Triglyceride | Metabolite | L-HDL-TG (ChEBI) | Triglycerides in large HDL |
| Triglyceride | Metabolite | L-LDL-TG (ChEBI) | Triglycerides in large LDL |
| Triglyceride | Metabolite | L-VLDL-TG (ChEBI) | Triglycerides in large VLDL |
| Triglyceride | Metabolite | LDL-TG (ChEBI) | |
| Triglyceride | Metabolite | M-HDL-TG (ChEBI) | Triglycerides in mediumHDL |
| Triglyceride | Metabolite | M-LDL-TG (ChEBI) | Triglycerides in medium LDL |
| Triglyceride | Metabolite | M-VLDL-TG (ChEBI) | Triglycerides in medium VLDL |
| Triglyceride | Metabolite | S-HDL-TG (ChEBI) | Triglycerides in small HDL |
| Triglyceride | Metabolite | S-LDL-TG (ChEBI) | Triglycerides in small LDL |
| Triglyceride | Metabolite | S-VLDL-TG (ChEBI) | Triglycerides in small VLDL |
| Triglyceride | Metabolite | VLDL-TG (ChEBI) | |
| Triglyceride | Metabolite | XL-HDL-TG (ChEBI) | Triglycerides in very large HDL |
| Triglyceride | Metabolite | XL-VLDL-TG (ChEBI) | Triglycerides in very large VLDL |
| Triglyceride | Metabolite | XS-VLDL-TG (ChEBI) | Triglycerides in very small VLDL |
| Triglyceride | Metabolite | XXL-VLDL-TG (ChEBI) | Triglycerides in chylomicrons and extremely large VLDL |
| XL HDL | Pathway | GO:0034364 (GeneOntology) | A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. |
| XL VLDL | Pathway | GO:0034361 (GeneOntology) | A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. |
| XS VLDL | Pathway | GO:0034361 (GeneOntology) | A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. |
Annotated Interactions
No annotated interactions
