Integrin-mediated cell adhesion (Homo sapiens)

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12cell maintenanceIntegrin betaITGAITGBERKF-actinPAKIntegrin alphaPAKRAFMEKECMcell proliferationcell motilityp130 Cascell maintenancePI3KC3GCAPNCAPNF-actinRAP1AITGA10RHOITGA4VAV2CSKITGA9CAPN3HRASSRCCAPN11Phosphatidylinositolsignaling systemAKT1ARAFITGB1CAPN7CDC42PDPK1RAC1CAPN2ARHGEF7SRCGRB2ITGA6p110SHC1PTK2ITGA11PAK1VASPPAK2BCAR1SOS1ITGADMAP2K6SHC3ROCK1MAPK1CAPNS1VCLPAK6PAK3PIK3R2MYO-PITGB4RAC2MAP2K3MAPK12CAPN5MIR34CITGA8SORBS1RAP1BITGAERAC3ITGA1MYOCAPN9CRKCAPN1GIT2ITGAMPAK4MAP2K1MAPK4ROCK2ITGA2BFYNACTNPXNITGB2MAPK10CAV2AKT2CAV3RAPGEF1BRAFAKT3MAP2K2ITGA2DOCK1MAPK7ITGA5CAPN6CAV1TNS1ITGA3MAP2K5ITGALITGB3ZYXSEPP1ITGB8RAF1ILKITGB5MAPK6PI5KCAPN10ITGB6MYLK2VAV3ITGAXITGA7TLN1PTK2ITGB7ITGAV


Description

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle.

Description reference: Wikipedia

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia
  2. Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126267view15:55, 19 April 2023EgonwLicense is CCZero
116785view09:54, 14 May 2021EweitzModified title
106621view20:48, 12 September 2019KhanspersModified description
105461view05:10, 8 August 2019KhanspersModified description
103465view19:20, 5 March 2019AlexanderPicoModified description
88160view07:51, 29 July 2016Mkutmongraphical line fix
80036view00:19, 2 May 2015KhanspersAdded MIR34C
79982view15:27, 29 April 2015Zarianotated MYO-P gene
71391view18:42, 17 October 2013MaintBotAutomated update of data sources
71275view22:33, 16 October 2013MaintBotAutomated update of data sources
70020view01:51, 12 July 2013AlexanderPicoModified title
63223view21:02, 8 May 2013MaintBotUpdating gpml version
62693view21:36, 1 May 2013MaintBotupdated uniprot data source
44862view09:56, 6 October 2011MartijnVanIerselOntology Term : 'integrin mediated signaling pathway' added !
41226view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38886view19:04, 24 September 2010KhanspersAdded pathway link
38885view18:59, 24 September 2010Khanspers
35591view15:40, 12 February 2010Thomasadded literature
35590view15:38, 12 February 2010ThomasModified description
31991view13:14, 14 August 2009MaintBotFixed group labels
21067view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Integrin-mediated cell adhesion KEGG]] moved to [[Pathway:WP185]]: Moved to stable identifier
14947view16:14, 24 May 2008MartijnVanIersellinked up
13024view11:07, 17 May 2008MaintBotSticky edges patch by Sjoerd
8218view13:46, 7 January 2008MaintBot[[Pathway:Human:Integrin-mediated cell adhesion KEGG]] moved to [[Pathway:Homo sapiens:Integrin-mediated cell adhesion KEGG]]: Renaming species
7729view16:13, 18 December 2007MaintBotfixed category names
7268view12:41, 4 November 2007MaintBotAdded categories to GPML
6345view22:18, 22 May 2007169.230.77.174gpml file for [[Human:Integrin-mediated_cell_adhesion_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTNGeneProduct
AKT1GeneProduct207 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2GeneProduct208 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
AKT3GeneProduct10000 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
ARAFGeneProduct369 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
ARHGEF7GeneProduct8874 (Entrez Gene) ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
BCAR1GeneProduct9564 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
BRAFGeneProduct673 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAPN10GeneProduct11132 (Entrez Gene) CAPN10; calpain 10 [EC:3.4.22.17
CAPN11GeneProduct11131 (Entrez Gene) CAPN11; calpain 11 [EC:3.4.22.17]
CAPN1GeneProduct823 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
CAPN2GeneProduct824 (Entrez Gene) CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
CAPN3GeneProduct825 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:3.4.22.17]
CAPN5GeneProduct726 (Entrez Gene) CAPN5; calpain
CAPN6GeneProduct827 (Entrez Gene) CAPN6; calpain 6 [EC:3.4.22.17]
CAPN7GeneProduct23473 (Entrez Gene) CAPN7; calpain 7 [EC:3.4.22.17
CAPN9GeneProduct10753 (Entrez Gene) CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPNS1GeneProduct826 (Entrez Gene) CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
CAV1GeneProduct857 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
CAV2GeneProduct858 (Entrez Gene) CAV2; caveolin 2
CAV3GeneProduct859 (Entrez Gene) CAV3; caveolin 3
CDC42GeneProduct998 (Entrez Gene) CDC42; cell division cycle 42 (GTP binding protein 25kD)
CRKGeneProduct1398 (Entrez Gene) CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CSKGeneProduct1445 (Entrez Gene) CSK; c-src tyrosine kinase [EC:2.7.1.112]
DOCK1GeneProduct1793 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
FYNGeneProduct2534 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GIT2GeneProduct9815 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
GRB2GeneProduct2885 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
HRASGeneProduct3265 (Entrez Gene)
ILKGeneProduct3611 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA10GeneProduct8515 (Entrez Gene)
ITGA11GeneProduct22801 (Entrez Gene)
ITGA1GeneProduct3672 (Entrez Gene)
ITGA2GeneProduct3673 (Entrez Gene)
ITGA2BGeneProduct3674 (Entrez Gene)
ITGA3GeneProduct3675 (Entrez Gene)
ITGA4GeneProduct3676 (Entrez Gene)
ITGA5GeneProduct3678 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene)
ITGA7GeneProduct3679 (Entrez Gene)
ITGA8GeneProduct8516 (Entrez Gene)
ITGA9GeneProduct3680 (Entrez Gene)
ITGADGeneProduct3681 (Entrez Gene)
ITGAEGeneProduct3682 (Entrez Gene)
ITGALGeneProduct3683 (Entrez Gene)
ITGAMGeneProduct3684 (Entrez Gene)
ITGAVGeneProduct3685 (Entrez Gene)
ITGAXGeneProduct3687 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
ITGB2GeneProduct3689 (Entrez Gene)
ITGB3GeneProduct3690 (Entrez Gene)
ITGB4GeneProduct3691 (Entrez Gene)
ITGB5GeneProduct3693 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
ITGB7GeneProduct3695 (Entrez Gene)
ITGB8GeneProduct3696 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2GeneProduct5605 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
MAP2K3GeneProduct5606 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5GeneProduct5607 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6GeneProduct5608 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK10GeneProduct5602 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
MAPK1GeneProduct5594 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK4GeneProduct5596 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK6GeneProduct5597 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAPK7GeneProduct5598 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MIR34CGeneProductENSG00000207562 (Ensembl)
MYLK2GeneProduct85366 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
MYOGeneProduct
MYO-PGeneProductENSG00000138347 (Ensembl)
PAK1GeneProduct5058 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
PAK2GeneProduct5062 (Entrez Gene) PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3GeneProduct5063 (Entrez Gene) PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4GeneProduct10298 (Entrez Gene) PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6GeneProduct56924 (Entrez Gene) PAK6; p21(CDKN1A)-activated kinase
PDPK1GeneProduct5170 (Entrez Gene) PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
PI5KGeneProduct
PIK3R2GeneProduct5296 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
PTK2GeneProduct5747 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PXNGeneProduct5829 (Entrez Gene) PXN; paxillin
Phosphatidylinositol signaling systemPathway
RAC1GeneProduct5879 (Entrez Gene) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2GeneProduct5880 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3GeneProduct5881 (Entrez Gene) RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
RAF1GeneProduct5894 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1AGeneProduct5906 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAP1BGeneProduct5908 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RAPGEF1GeneProduct2889 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RHOGeneProduct6010 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
ROCK1GeneProduct6093 (Entrez Gene) ROCK1; Rho-associated coiled-coil containing protein kinase
ROCK2GeneProduct9475 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
SEPP1GeneProduct6414 (Entrez Gene) SEPP1; selenoprotein P plasma
SHC1GeneProduct6464 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3GeneProduct53358 (Entrez Gene) SHC3; neuronal Sh
SORBS1GeneProduct10580 (Entrez Gene) SH3D5; SH3-domain protein 5 (ponsin
SOS1GeneProduct6654 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SRCGeneProduct6714 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
TLN1GeneProduct7094 (Entrez Gene) TLN1; talin 1
TNS1GeneProduct7145 (Entrez Gene) TNS; tensi
VASPGeneProduct7408 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
VAV2GeneProduct7410 (Entrez Gene) VAV2; vav 2 oncogene
VAV3GeneProduct10451 (Entrez Gene) VAV3; vav 3 oncogene
VCLGeneProduct7414 (Entrez Gene) VCL; vinculin
ZYXGeneProduct7791 (Entrez Gene) ZYX; zyxin
p110GeneProduct

Annotated Interactions

No annotated interactions

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