Genetic alterations of lung cancer (Rattus norvegicus)

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213p16INK4A/RB pathwayp14ARF/p53 pathwayPPInhibitory signal Activating signalOncogenic signalingDNA damagePbinds on DP1,2Pik3cap16INK4AErbb2EgfrERKMap2k1Raf1Rasl11bAkt1MYCTgfb1Smad4Smad2TGF-beta R1/2p15INK4BCcnd1Cdk4RBE2FDmp1p14ARF4Mdm2CBPTp53cell cycle arrestAtmp300Ccne1Cdk2p21Pik3cd


Description

Expression patterns of two major tumor suppressor pathways in lung cancer. These pathways are functionally linked to lung cancer and play role as a component of checkpoints and growth inhibitory pathways. Components which/who are activated in this pathway are Egfr, Erbb2, Rasl11b, and MYC in the Oncogenic singalling part. Frequent inactivated are TGF-beta R1/2, RB, p16INK4A, Tp53, and p14ARF, whie infrequent inactivated are Smad2 and Sma4. Both, the p14ARF/p53 and the p16INK4A/RB pathway lead to cell cycle arrest.

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Bibliography

  1. Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC; ''HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.''; Nat Cell Biol, 2001 PubMed Europe PMC Scholia
  2. Osada H, Takahashi T; ''Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.''; Oncogene, 2002 PubMed Europe PMC Scholia
  3. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M; ''Repression of p15INK4b expression by Myc through association with Miz-1.''; Nat Cell Biol, 2001 PubMed Europe PMC Scholia
  4. Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, Roussel MF; ''Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126776view05:44, 22 June 2023EgonwBlack boxes
126775view05:42, 22 June 2023EgonwRemoved the fill colors
126774view05:39, 22 June 2023EgonwModified description
126413view20:14, 26 April 2023EgonwLicense is CCZero
110692view13:49, 28 May 2020EgonwAdded missing @Type annotation
108361view14:51, 12 December 2019Marvin M2Connected lines
108260view14:46, 3 December 2019L DupuisConverted interactions in legend to graphical lines
108109view10:18, 29 November 2019FehrhartOntology Term : 'lung cancer' added !
108108view10:18, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
85190view15:44, 23 April 2016EgonwReplaced a mim-conversion with Arrow.
82984view00:10, 17 November 2015Mkutmonfixed special symbols in reference
82983view00:07, 17 November 2015Mkutmonfixed outdatded identifiers
81935view00:01, 6 September 2015AlexanderPicoQuick edit to datanode annotation or property
81934view00:00, 6 September 2015AlexanderPicoQuick edit to datanode annotation or property
81933view23:58, 5 September 2015AlexanderPicoQuick edit to datanode annotation or property
81932view23:57, 5 September 2015AlexanderPicoQuick edit to datanode annotation or property
81931view23:55, 5 September 2015AlexanderPicoQuick edit to datanode annotation or property
81662view16:09, 22 August 2015MaintBotFixed weird characters in autors names.
81285view10:22, 14 August 2015Jmeliusupdate data nodes labels
78466view10:27, 7 January 2015MaintBotadded missing graphIds
71839view19:44, 18 October 2013MaintBotremoved data source from nodes without identifier
70124view19:27, 12 July 2013MaintBotupdated to 2013 schema
70123view19:27, 12 July 2013MaintBotModified title
67281view10:31, 26 June 2013Christine ChichesterOntology Term : 'lung cancer pathway' added !
58960view18:32, 21 February 2013MaintBotUpdated Ensembl data source
44969view14:01, 6 October 2011Mkutmonconnected some lines
42200view21:02, 7 March 2011KhanspersModified categories
42199view21:01, 7 March 2011KhanspersFixed unconnected lines
41729view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
40393view14:38, 23 February 2011GustavModified description
40392view14:37, 23 February 2011Gustav
40389view14:33, 23 February 2011GustavPeriodical save, work in progress
40386view14:22, 23 February 2011GustavPeriodical save, work in progress
40377view13:46, 23 February 2011Gustav
40372view13:42, 23 February 2011GustavModified description
40360view13:22, 23 February 2011Gustav
40359view13:19, 23 February 2011GustavModified description
40357view13:16, 23 February 2011Gustav
40356view13:15, 23 February 2011GustavPeriodical save, work in progress
40352view13:04, 23 February 2011GustavPeriodical save, work in progress
40348view12:54, 23 February 2011GustavPeriodical save, work in progress
40341view12:34, 23 February 2011GustavPeriodical save, work in progress
40336view12:23, 23 February 2011GustavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProductENSRNOG00000028629 (Ensembl)
AtmGeneProductENSRNOG00000029773 (Ensembl)
CBPGeneProductENSRNOG00000005330 (Ensembl)
Ccnd1GeneProductENSRNOG00000020918 (Ensembl)
Ccne1GeneProductENSRNOG00000014786 (Ensembl)
Cdk2GeneProductENSRNOG00000006469 (Ensembl)
Cdk4GeneProductENSRNOG00000025602 (Ensembl)
Dmp1GeneProductENSRNOG00000002167 (Ensembl)
E2FGeneProductENSRNOG00000016708 (Ensembl)
ERKGeneProductENSRNOG00000001849 (Ensembl)
EgfrGeneProductENSRNOG00000004332 (Ensembl)
Erbb2GeneProductENSRNOG00000006450 (Ensembl)
MYCGeneProductENSRNOG00000042556 (Ensembl)
Map2k1GeneProductENSRNOG00000010176 (Ensembl)
Mdm2GeneProductENSRNOG00000006304 (Ensembl)
Pik3caGeneProductENSRNOG00000056371 (Ensembl)
Pik3cdGeneProductENSRNOG00000016846 (Ensembl)
RBGeneProductENSRNOG00000016029 (Ensembl)
Raf1GeneProductENSRNOG00000010153 (Ensembl)
Rasl11bGeneProductENSRNOG00000002097 (Ensembl)
Smad2GeneProductENSRNOG00000018140 (Ensembl)
Smad4GeneProductENSRNOG00000051965 (Ensembl)
TGF-beta R1/2GeneProductENSRNOG00000002418 (Ensembl)
Tgfb1GeneProductENSRNOG00000020652 (Ensembl)
Tp53GeneProductENSRNOG00000010756 (Ensembl)
cell cycle arrestPathway
p14ARFGeneProduct
p15INK4BGeneProduct
p16INK4AGeneProduct
p21GeneProductENSRNOG00000000521 (Ensembl)
p300GeneProductENSRNOG00000000190 (Ensembl)

Annotated Interactions

No annotated interactions

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