LIN-12/Notch Lateral Signaling (Caenorhabditis elegans)
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Description
Lateral signaling targets and negative regulation of LET-23 signaling. The LIN-12/Notch pathway plays two related roles in vulval development; to prevent adjacent induced vulval precursor cells (VPCs) from both becoming 1° VPCs and to induce VPCs adjacent to the 1°VPC to take a 2° cell fate.
See figure 14 in http://www.wormbook.org/chapters/www_vulvaldev/vulvaldev.pdf.
Quality Tags
Ontology Terms
Saving...Bibliography
- Yoo AS, Bais C, Greenwald I; ''Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.''; Science, 2004 PubMed Europe PMC Scholia
- Sternberg PW; ''Vulval development.''; WormBook, 2005 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| LET-23 | GeneProduct | WBGene00002299 (Ensembl)  | |
| LET-60 | GeneProduct | WBGene00002335 (Ensembl) | |
| LIN-12 | GeneProduct | WBGene00003001 (Ensembl) | |
| MPK-1 | GeneProduct | WBGene00003401 (Ensembl) | |
| apm-1 | GeneProduct | WBGene00000150 (Ensembl) | |
| ark-1 | GeneProduct | WBGene00000186 (Ensembl) | |
| dpy-23 | GeneProduct | WBGene00001082 (Ensembl) | |
| gap-1 | GeneProduct | WBGene00001515 (Ensembl) | |
| lip-1 | GeneProduct | WBGene00003043 (Ensembl) | |
| lst-1 | GeneProduct | WBGene00003083 (Ensembl) | |
| lst-2 | GeneProduct | WBGene00003084 (Ensembl) | |
| lst-3 | GeneProduct | WBGene00003085 (Ensembl) | |
| lst-4 | GeneProduct | WBGene00003086 (Ensembl) | |
| sli-1 | GeneProduct | WBGene00004829 (Ensembl) | |
| unc-101 | GeneProduct | WBGene00006829 (Ensembl) |
Annotated Interactions
No annotated interactions
