Estrogen receptor pathway (Bos taurus)

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42MetabolismTranscriptionTranscription factorsDrug and steroid metabolismCell proliferation and apoptosisLigandLigandSP1ESR1JUN49ESR1ESR1GenesTATA boxEREESR1ESR1ESR1ESR149ESR1LigandLigandCoregulatorsPDK4STAT3ACOX1GPAMPCK1CYP1A1PPARACYP1A2NR0B2CYP1B1LigandLigandLigand


Description

The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2881(79603) with a 100.0% conversion rate.

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Bibliography

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History

CompareRevisionActionTimeUserComment
129337view09:11, 27 March 2024MkutmonOntology Term : 'estrogen signaling pathway' added !
117506view11:05, 21 May 2021EweitzModified title
80733view15:23, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACOX1GeneProductENSBTAG00000030174 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161533
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061
ESR1GeneProductENSBTAG00000007159 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831
GPAMGeneProductENSBTAG00000011917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119927
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177606
LigandMetaboliteCHEBI:48705 (ChEBI)
NR0B2GeneProductENSBTAG00000014848 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131910
PCK1GeneProductENSBTAG00000001936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124253
PDK4GeneProductENSBTAG00000014069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000004799
PPARAGeneProductENSBTAG00000008063 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186951
SP1GeneProductENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185591
STAT3GeneProductENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168610

Annotated Interactions

No annotated interactions
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