The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway WP585(80201) with a 95.0% conversion rate.
Fu XY; ''A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s).''; Cell, 1992 PubMedEurope PMCScholia
You M, Yu DH, Feng GS; ''Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.''; Mol Cell Biol, 1999 PubMedEurope PMCScholia
Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H; ''MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.''; Oncogene, 2008 PubMedEurope PMCScholia
Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C; ''The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.''; Nature, 1993 PubMedEurope PMCScholia
Baychelier F, Nardeux PC, Cajean-Feroldi C, Ermonval M, Guymarho J, Tovey MG, Eid P; ''Involvement of the Gab2 scaffolding adapter in type I interferon signalling.''; Cell Signal, 2007 PubMedEurope PMCScholia
Song MM, Shuai K; ''The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities.''; J Biol Chem, 1998 PubMedEurope PMCScholia
Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K; ''Inhibition of Stat1-mediated gene activation by PIAS1.''; Proc Natl Acad Sci U S A, 1998 PubMedEurope PMCScholia
Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR; ''Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.''; J Biol Chem, 1995 PubMedEurope PMCScholia
Liu X, Zhang Z, Sun L, Chai N, Tang S, Jin J, Hu H, Nie Y, Wang X, Wu K, Jin H, Fan D; ''MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4.''; Carcinogenesis, 2011 PubMedEurope PMCScholia
Ahmad S, Alsayed YM, Druker BJ, Platanias LC; ''The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein.''; J Biol Chem, 1997 PubMedEurope PMCScholia
Uddin S, Fish EN, Sher D, Gardziola C, Colamonici OR, Kellum M, Pitha PM, White MF, Platanias LC; ''The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors.''; Blood, 1997 PubMedEurope PMCScholia
Uddin S, Gardziola C, Dangat A, Yi T, Platanias LC; ''Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase.''; Biochem Biophys Res Commun, 1996 PubMedEurope PMCScholia
Farrar JD, Smith JD, Murphy TL, Murphy KM; ''Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2.''; J Biol Chem, 2000 PubMedEurope PMCScholia
Uddin S, Majchrzak B, Woodson J, Arunkumar P, Alsayed Y, Pine R, Young PR, Fish EN, Platanias LC; ''Activation of the p38 mitogen-activated protein kinase by type I interferons.''; J Biol Chem, 1999 PubMedEurope PMCScholia
Platanias LC, Uddin S, Yetter A, Sun XJ, White MF; ''The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.''; J Biol Chem, 1996 PubMedEurope PMCScholia
Fish EN, Uddin S, Korkmaz M, Majchrzak B, Druker BJ, Platanias LC; ''Activation of a CrkL-stat5 signaling complex by type I interferons.''; J Biol Chem, 1999 PubMedEurope PMCScholia
Gutch MJ, Daly C, Reich NC; ''Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor.''; Proc Natl Acad Sci U S A, 1992 PubMedEurope PMCScholia
Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA; ''Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.''; EMBO J, 1994 PubMedEurope PMCScholia
Schindler C, Shuai K, Prezioso VR, Darnell JE Jr; ''Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.''; Science, 1992 PubMedEurope PMCScholia
Yan H, Krishnan K, Lim JT, Contillo LG, Krolewski JJ; ''Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction.''; Mol Cell Biol, 1996 PubMedEurope PMCScholia
Novick D, Cohen B, Rubinstein M; ''The human interferon alpha/beta receptor: characterization and molecular cloning.''; Cell, 1994 PubMedEurope PMCScholia
Uddin S, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, White MF, Platanias LC; ''Interaction of p59fyn with interferon-activated Jak kinases.''; Biochem Biophys Res Commun, 1997 PubMedEurope PMCScholia
Burfoot MS, Rogers NC, Watling D, Smith JM, Pons S, Paonessaw G, Pellegrini S, White MF, Kerr IM; ''Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons.''; J Biol Chem, 1997 PubMedEurope PMCScholia
Platanias LC, Uddin S, Bruno E, Korkmaz M, Ahmad S, Alsayed Y, Van Den Berg D, Druker BJ, Wickrema A, Hoffman R; ''CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors.''; Exp Hematol, 1999 PubMedEurope PMCScholia
Colamonici OR, Domanski P; ''Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21.''; J Biol Chem, 1993 PubMedEurope PMCScholia
David M, Chen HE, Goelz S, Larner AC, Neel BG; ''Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.''; Mol Cell Biol, 1995 PubMedEurope PMCScholia
Owczarek CM, Hwang SY, Holland KA, Gulluyan LM, Tavaria M, Weaver B, Reich NC, Kola I, Hertzog PJ; ''Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2.''; J Biol Chem, 1997 PubMedEurope PMCScholia
Novick D, Cohen B, Rubinstein M; ''Soluble interferon-alpha receptor molecules are present in body fluids.''; FEBS Lett, 1992 PubMedEurope PMCScholia
Uddin S, Yenush L, Sun XJ, Sweet ME, White MF, Platanias LC; ''Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase.''; J Biol Chem, 1995 PubMedEurope PMCScholia
Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff SJ, Owczarek CM, Hertzog PJ; ''Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock.''; J Immunol, 2014 PubMedEurope PMCScholia
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