Metabolism of dichloroethylene by CYP450 (Homo sapiens)

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1-91,1-Dichloroethylene epoxideChloroacetic acidglutathione S-transferase2,2-dichloro-1,1-ethanediol1,1-DichloroethyleneCYP2E12-(S-Glutathionyl)acetyl chlorideChloroacetyl chloride2,2-DichloroacetaldehydeS-(2-Chloroacetyl)glutathioneS-(2,2-dichloro-1-hydroxy)-1-ethyl glutathione2-S-Glutathionyl acetate CYP2E1glutathione S-transferaseCYP2E1glutathione S-transferase


Description

This pathway describes the metabolism of dichloroethylene by Cytochrome P450 enzymes. Source: KEGG Metabolism of xenobiotics by cytochrome P450.

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Bibliography

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  1. Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ; ''Role of quinones in toxicology.''; Chem Res Toxicol, 2000 PubMed Europe PMC Scholia
  2. Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG; ''Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.''; Drug Metab Dispos, 2004 PubMed Europe PMC Scholia
  3. Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C; ''Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.''; Drug Metab Rev, 2002 PubMed Europe PMC Scholia
  4. Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP; ''Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.''; Drug Metab Dispos, 1997 PubMed Europe PMC Scholia
  5. Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR; ''Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.''; Chem Res Toxicol, 1999 PubMed Europe PMC Scholia
  6. Halladay JS, Sauer JM, Sipes IG; ''Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.''; Drug Metab Dispos, 1999 PubMed Europe PMC Scholia
  7. Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR; ''Possible mechanism of liver necrosis caused by aromatic organic compounds.''; Proc Natl Acad Sci U S A, 1971 PubMed Europe PMC Scholia
  8. Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS; ''Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.''; Drug Metab Dispos, 2005 PubMed Europe PMC Scholia
  9. Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P; ''Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.''; Cancer Epidemiol Biomarkers Prev, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117778view13:59, 22 May 2021EweitzModified title
106750view13:23, 17 September 2019MaintBotHMDB identifier normalization
106556view00:31, 6 September 2019KhanspersModified description
88587view19:29, 11 August 2016Mkutmonfix unconnected lines
87782view11:12, 25 July 2016ElisaOntology Term : 'classic metabolic pathway' added !
85995view11:25, 23 June 2016EgonwSmall typo fix.
85973view14:06, 22 June 2016JacobwindsorModified description
85972view14:06, 22 June 2016JacobwindsorAdd references
85971view13:39, 22 June 2016FehrhartAdded MIM interactions and connected lines
85969view12:58, 22 June 2016FehrhartModified description
85968view12:56, 22 June 2016FehrhartAdded anchors
85967view00:24, 22 June 2016KhanspersOntology Term : 'PW:0000147' removed !
85966view00:24, 22 June 2016KhanspersOntology Term : 'metabolic pathway of secondary metabolites' added !
85914view16:33, 21 June 2016JacobwindsorFix catalysis with suggestion
85913view16:25, 21 June 2016JacobwindsorPeriodical save, work in progress
85880view20:33, 19 June 2016JacobwindsorModified description
85879view20:29, 19 June 2016JacobwindsorFinished pathway
85878view20:25, 19 June 2016JacobwindsorPeriodical save, work in progress
85877view20:15, 19 June 2016JacobwindsorNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,1-Dichloroethylene epoxideMetaboliteHMDB0060333 (HMDB)
1,1-DichloroethyleneMetabolite6366 (PubChem-compound)
2,2-DichloroacetaldehydeMetaboliteHMDB0060357 (HMDB)
2,2-dichloro-1,1-ethanediolMetabolite85275 (PubChem-compound)
2-(S-Glutathionyl)acetyl chlorideMetaboliteHMDB0060342 (HMDB)
2-S-Glutathionyl acetate Metabolite11954071 (PubChem-compound)
CYP2E1GeneProductENSG00000130649 (Ensembl)
Chloroacetic acidMetaboliteHMDB0031331 (HMDB)
Chloroacetyl chlorideMetaboliteHMDB0060452 (HMDB)
S-(2,2-dichloro-1-hydroxy)-1-ethyl glutathioneMetabolite11954070 (PubChem-compound)
S-(2-Chloroacetyl)glutathioneMetaboliteHMDB0060505 (HMDB)
glutathione S-transferaseProtein119391 (KEGG Genes)

Annotated Interactions

No annotated interactions

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