Ethanol effects on histone modifications (Homo sapiens)

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2Histone deacetylasesHistone acetyltransferasesmethylatedHistones1KAT2BTYMSHDAC2ATF2S-AdenosylmethioninedTMPELP35,10-MTHFdUMPPyrimidinesFolic acidDihydrofolateEthanolMTRMAT IIIGlycineL-SerineTetrahydrofolateL-MethionineSLC19A1HAT15-MTHFS-AdenosylhomocysteineMTHFRAHCYHDAC1HomocysteineMAT1ADHFREHMT2Nucleic acidsMitochondrial damageAcetaldehydeACSS2ADH1BCYP2E1ADH1AAcetateAcetyl-CoAALDH1A1Coenzyme AALDH2Reactive oxygen species2. EtOH increases histone acetylation via oxidative stress and increase of acetate levelsADH1CALDH1A2ALDH1A3Reactive oxygen speciesReactive oxygen species1. EtOH reduces histone methylation via one-carbon metabolismHDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HDAC10HistonesacetylatedHistones


Description

Ethanol effects on histone modifications which contribute to the development of fetal alcohol syndrome.

Pathway based on Chater-Diehl et al. 2017 (https://doi.org/10.1016/j.alcohol.2017.01.005).

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Lee KK, Workman JL; ''Histone acetyltransferase complexes: one size doesn't fit all''; Nat Rev Mol Cell Biol., 2007 PubMed Europe PMC Scholia
  2. Chater-Diehl EJ, Laufer BI, Singh SM; ''Changes to histone modifications following prenatal alcohol exposure: An emerging picture.''; Alcohol, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125197view10:24, 29 January 2023EgonwChEBI id of the specific compound, not the class
107156view14:24, 17 September 2019MaintBotChEBI identifier normalization
106772view13:25, 17 September 2019MaintBotHMDB identifier normalization
106409view21:55, 28 August 2019KhanspersModified description
105589view04:44, 10 August 2019KhanspersModified description
93015view19:34, 24 July 2017Khanspersfixed unconnected interaction
93010view16:08, 23 July 2017FehrhartAdded annotations
93009view15:58, 23 July 2017FehrhartConnected lines
92563view10:16, 16 June 2017Fehrhartwork in progress
92562view10:06, 16 June 2017Fehrhartwork in progress
92561view10:05, 16 June 2017Fehrhartwork in progress
92525view12:57, 13 June 2017Fehrhartwork in progress
92524view11:04, 13 June 2017FehrhartModified description
92523view11:01, 13 June 2017FehrhartOntology Term : 'fetal alcohol spectrum disorder' added !
92521view08:56, 13 June 2017Marvin M2Ontology Term : 'altered histone modification pathway' added !
92520view08:49, 13 June 2017FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5,10-MTHFMetaboliteHMDB0001533 (HMDB)
5-MTHFMetaboliteHMDB0001396 (HMDB)
ACSS2GeneProductENSG00000131069 (Ensembl)
ADH1AGeneProductENSG00000187758 (Ensembl)
ADH1BGeneProductENSG00000196616 (Ensembl)
ADH1CGeneProductENSG00000248144 (Ensembl)
AHCYGeneProductENSG00000101444 (Ensembl)
ALDH1A1GeneProductENSG00000165092 (Ensembl)
ALDH1A2GeneProductENSG00000128918 (Ensembl)
ALDH1A3GeneProductENSG00000184254 (Ensembl)
ALDH2GeneProductENSG00000111275 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
AcetaldehydeMetaboliteHMDB0000990 (HMDB)
AcetateMetaboliteCHEBI:30089 (ChEBI)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
CYP2E1GeneProductENSG00000130649 (Ensembl)
Coenzyme AMetaboliteHMDB0001423 (HMDB)
DHFRGeneProductENSG00000228716 (Ensembl)
DihydrofolateMetaboliteCHEBI:15633 (ChEBI)
EHMT2GeneProductENSG00000204371 (Ensembl) G9a
ELP3GeneProductENSG00000134014 (Ensembl)
EthanolMetaboliteHMDB0000108 (HMDB)
Folic acidMetaboliteHMDB0000121 (HMDB)
GlycineMetaboliteHMDB0000123 (HMDB)
HAT1GeneProductENSG00000128708 (Ensembl)
HDAC10GeneProductENSG00000100429 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
HDAC3GeneProductENSG00000171720 (Ensembl)
HDAC4GeneProductENSG00000068024 (Ensembl)
HDAC5GeneProductENSG00000108840 (Ensembl)
HDAC6GeneProductENSG00000094631 (Ensembl)
HDAC7GeneProductENSG00000061273 (Ensembl)
HDAC8GeneProductENSG00000147099 (Ensembl)
HDAC9GeneProductENSG00000048052 (Ensembl)
HomocysteineMetaboliteHMDB0000742 (HMDB)
KAT2BGeneProductENSG00000114166 (Ensembl) also known as PCAF
L-MethionineMetaboliteHMDB0000696 (HMDB)
L-SerineMetaboliteHMDB0000187 (HMDB)
MAT IIIGeneProduct
MAT1AGeneProductENSG00000151224 (Ensembl)
MTHFRGeneProductENSG00000177000 (Ensembl)
MTRGeneProductENSG00000116984 (Ensembl)
Nucleic acidsMetaboliteCHEBI:33696 (ChEBI)
Pyrimidines MetaboliteCHEBI:39447 (ChEBI)
Reactive oxygen speciesMetaboliteCHEBI:26523 (ChEBI)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
SLC19A1GeneProductENSG00000173638 (Ensembl) Formerly known as RFC1
TYMSGeneProductENSG00000176890 (Ensembl)
TetrahydrofolateMetaboliteCHEBI:67016 (ChEBI)
dTMPMetaboliteHMDB0001227 (HMDB)
dUMPMetaboliteHMDB0001409 (HMDB)

Annotated Interactions

No annotated interactions

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