MAP3K1 role in promoting and blocking gonadal determination (Homo sapiens)

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Description

This pathway summarizes the differential signaling in sex development in the human fetus. Disorders of sex development can derive from dysfunction of one or more genes in this pathway.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Ostrer H; ''Disorders of sex development (DSDs): an update.''; J Clin Endocrinol Metab, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135856view12:41, 19 November 2024EweitzRefine alignment, standardize case
135855view12:39, 19 November 2024EweitzEconomize layout
129657view00:28, 22 May 2024EweitzOntology Term : 'signaling pathway pertinent to development' added !
129656view00:26, 22 May 2024EweitzEconomize layout
110081view09:11, 16 April 2020FehrhartModified description
110080view09:10, 16 April 2020FehrhartOntology Term : 'signaling pathway' added !
110079view09:09, 16 April 2020FehrhartAdded reference and connected unconnected line
109745view11:35, 30 March 2020TilmansModified title
109744view11:34, 30 March 2020TilmansOntology Term : '46 XY gonadal dysgenesis' added !
109743view11:33, 30 March 2020TilmansOntology Term : 'gonadal dysgenesis' added !
109742view11:33, 30 March 2020TilmansOntology Term : '46 XX gonadal dysgenesis' added !
109741view11:28, 30 March 2020TilmansNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AXIN1GeneProductENSG00000103126 (Ensembl)
CTNNB1ProteinB4DGU4 (Uniprot-TrEMBL)
FGF9GeneProductENSG00000102678 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FOXL2GeneProductENSG00000183770 (Ensembl)
FRAT1GeneProductENSG00000165879 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K4GeneProductENSG00000085511 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
ROCK1GeneProductENSG00000067900 (Ensembl)
SOX9GeneProductENSG00000125398 (Ensembl)
SRYGeneProductENSG00000184895 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4872"
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