Opioid receptor pathways (Homo sapiens)
From WikiPathways
Description
Opioid signaling from four receptor subtypes.
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Ontology Terms
Bibliography
- Schattauer SS, Bedini A, Summers F, Reilly-Treat A, Andrews MM, Land BB, Chavkin C; ''Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation.''; J Biol Chem, 2019 PubMed Europe PMC Scholia
- Rankovic M, Jacob L, Rankovic V, Brandenburg LO, Schröder H, Höllt V, Koch T; ''ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2.''; Cell Signal, 2009 PubMed Europe PMC Scholia
- Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R; ''PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.''; Br J Pharmacol, 2014 PubMed Europe PMC Scholia
- Tanner E; ''[Life expectancy in sarcoidosis].''; Lebensversicher Med, 1977 PubMed Europe PMC Scholia
- Rozenfeld-Granot G, Toren A, Amariglio N, Nagler A, Rosenthal E, Biniaminov M, Brok-Simoni F, Rechavi G; ''MAP kinase activation by mu opioid receptor in cord blood CD34(+)CD38(-) cells.''; Exp Hematol, 2002 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
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ADCY1 | Protein | 107 (Entrez Gene) | [Pubmed: 23682813] have shown that DAMGO treatment stimulates OPRM1 and induces upregulation of ADCY1 in mice striatum and prefrontal cortex |
ADCY5 | Protein | NP_000792.1 (NCBI Protein) | [Pubmed:24061856] have shown that morphine stimulates MOR and induces association of OPRM1 and ADCY5 in HEK293 cells |
ADCY6 | Protein | NP_000792.1 (NCBI Protein) | [Pubmed:24061856] have shown that morphine stimulates MOR and induces association of OPRM1 and ADCY6 in HEK293 cells |
ADCY8 | Protein | 114 (Entrez Gene) | [Pubmed: 23682813] have shown that DAMGO treatment stimulates OPRM1 and induces upregulation of ADCY8 in mice striatum and prefrontal cortex |
ADM | Protein | 133 (NCBI Protein) | [Pubmed:20844145] have shown that morphine stimulates MOR and induces upregulation of ADM in a PKC mediated manner in rat DRG neurons. |
AIF1 | Protein | 199 (NCBI Protein) | [Pubmed:19176808] have shown that morphine stimulates MOR and induces upregulation of AIF1 in rat microglia. |
AKT1 | GeneProduct | NP_005154.2 (NCBI Protein) | [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces the phosphorylation of AKT1 at S473 in a G alpha i/0 mediated manner in CHO-KOR cells and mice striatal neurons |
AKT | GeneProduct | NP_005154.2 (RefSeq) | [Pubmed:24654606] have shown that morphine stimulates MOR and induces phosphorylation of AKT1 at Ser473 and Thr308 in µ-SK-N-LO cells and mouse sensory DRG neurons. |
ALDH9A1 | Protein | 223 (Entrez Gene) | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of ALDH9A1 in CHO cells. |
APLN | Rna | 8862 (NCBI Protein) | [Pubmed:18591478] have shown that morphine stimulates MOR and induces downregulation of APLN in mouse lateral hypothalamus. |
APOD | Rna | 347 (NCBI Protein) | [Pubmed:18591478] have shown that morphine stimulates MOR and induces upregulation of APOD in mouse lateral hypothalamus. |
APQ4 | Rna | 361 (NCBI Protein) | [Pubmed:18591478] have shown that morphine stimulates MOR and induces downregulation of AQP4 in mouse lateral hypothalamus. |
ARC | Protein | 23237 (Entrez Gene) | [Pubmed:16211563] have shown that morphine stimulates MOR and induces upregulation of ARC in a PKC/MEK dependent manner in mouse striatum and Neuro2A cells. |
ARR3 | Protein | NP_004303.2 (NCBI Protein) | [Pubmed:22553358] have shown that morphine stimulates MOR and induces OPRM1 and ARR3 association in HEK293 cells |
ARRB1 | Protein | NP_004032.2 (NCBI Protein) | [Pubmed:22375000] have shown that DAMGO stimulates MOR and induces association of OPRM1 and ARRB1 in human neuroblastoma SH-SY5Y cells |
ARRB2 | Protein | NP_001244257.1 (NCBI Protein) |
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ATF2 | Protein | NP_001871.2 (NCBI Protein) | [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of ATF2 downstream of MAPK14 in NG108-15 cells. |
Adenylyl cyclase | GeneProduct | ||
B3GALNT1 | Rna | 8706 (NCBI Protein) | [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of B3GALNT1 in human chondrocytes. |
B3GALT6 | Rna | 126792 (NCBI Protein) | [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of B3GALT6 in human chondrocytes. |
B4GALT7 | Rna | 11285 (NCBI Protein) | [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of B4GALT7 in human chondrocytes. |
BAX | Protein | 581 (NCBI Protein) | [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of BAX in HL60 cells |
BCL2 | Protein | 596 (NCBI Protein) | [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces downregulation of BCL2 in HL60 cells |
BDNF | GeneProduct | 627 (Entrez Gene) | [Pubmed: 27634008] have shown that U50488 stimulates KOR and induces the downregulation of BDNF in mouse Hippocampus, prefrontal cortex and primart cortical neurons |
BDNF | Protein | 627 (NCBI Protein) | [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of BDNF in rat dorsal raphe nucleus. |
CACNA1B | GeneProduct | 774 (Entrez Gene) | [Pubmed:16311589] have shown that nociceptin stimulates ORL1 and induces translocation of OPRL1-CACNA1B complex from cell membrane to cytosol in CHO cells and rat DRG neurons. |
CACNB2 | Rna | 783 (Entrez Gene) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces upregulation of CACNB2 in mouse central extended amygdala |
CALCA | Protein | 796 (NCBI Protein) | [Pubmed:20844145] have shown that morphine stimulates MOR and induces upregulation of CALCA in a PKC mediated manner in rat DRG neurons. |
CAMK2A | Protein | NP_057065.2 (NCBI Protein) | [Pubmed:16697745] have shown that DPDPE stimulates DOR and induces CAMK2A phosphorylation at Thr286 in rat BDL cholangiocytes |
CAP1 | Rna | 10487 (Entrez Gene) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces upregulation of CAP1 in mouse central extended amygdala |
CASP1 | GeneProduct | NP_150634.1 (NCBI Protein) | [Pubmed:26162710] have shown that morphine stimulates MOR and induces cleavage induced activation of CASP1 in a PI3K/AKT mediated manner in rat spinal cord tissue. |
CASP3 | Protein | 836 (NCBI Protein) | [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces downregulation of CASP3 in cerebral ischemia and reperfusion brain model of rat. |
CBLN1 | Rna | 869 (NCBI Protein) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces downregulation of CBLN1 in mouse central extended amygdala |
CCK | Rna | 885 (Entrez Gene) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces downregulation of CCK in mouse central extended amygdala |
CCND1 | Rna | 155 (NCBI Protein) | [Pubmed:21801866] have shown that DALDA stimulates MOR and induced upregulation of CCND1 in CMT-93 cells |
CCR5 | GeneProduct | NP_000570.1 (NCBI Protein) | [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of CCR5 at S349 in a PRKCZ dependent manner in M13 cells |
CD14 | Protein | 929 (NCBI Protein) | [Pubmed: 17583593] have shown that morphine stimulates MOR induces downregulation of CD14 expression on the surface of human neutrophils |
CDC42 | Protein | NP_001034891.1 (NCBI Protein) |
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CDK5 | GeneProduct | NP_004926.1 (NCBI Protein) | [Pubmed:16879821] have shown that DAMGO stimulates OPRM1 and induces activation of CDK5 in SH-SY5Y cells. |
CDK5R1 | Protein | 8851 (NCBI Protein) | [Pubmed:16879821] have shown that DAMGO stimulates OPRM1 and induces upregulation of CDK5R1 in SH-SY5Y cells and rat embryonic hippocampal neurons. |
CELF2 | Rna | 10659 (Entrez Gene) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces upregulation of CELF2 in mouse central extended amygdala |
CREB1 | GeneProduct | NP_604391.1 (NCBI Protein) | [Pubmed:28097228] have shown that U-50,488H stimulates KOR and induces phosphorylation of CREB1 at S133 in porcine articular chondrocytes. |
CRHR1 | Protein | 1394 (NCBI Protein) | [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of CRHR1 in rat dorsal raphe nucleus. |
Calcium influx | Metabolite | ||
DLG4 | Rna | 1742 (NCBI Protein) | [Pubmed:20889977] have shown that buprenorphine stimulates MOR induces upregulation of DLG4 mRNA in rat astrocytic cultures from accumbens. |
DNMT3A | Protein | 1788 (Entrez Gene) | [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of DNMT3A in mouse spinal cord. |
Diacylglycerol | Metabolite | CHEBI:88364 (ChEBI) | |
E2F1 | Protein | 1869 (Entrez Gene) | [Pubmed:19765550] have shown that morphine stimulates MOR and induces upregulation of E2F1 in CEMx174 cells. |
E2F1 | Protein | NP_005216.1 (RefSeq) | [Pubmed:19765550] have shown that morphine stimulates MOR and induces the DNA binding of E2F1 to MOR promoter in CEMx174 cells. |
ECE2 | Protein | 9718 (NCBI Protein) | [Pubmed:24990314] have shown that DAMGO/dynorphin B stimulates MOR and induces upregulation of ECE2 in CHO cells. |
EEA1 | GeneProduct | NP_003557.3 (NCBI Protein) | [Pubmed:20354103] have shown that DAMGO stimulateS OPRM1 and incudes activation of EEA1 in SH-SY5Y cells. |
EGFR | GeneProduct | NP_005219.2 (NCBI Protein) | [Pubmed:17545478] have shown that DADLE stimulates DOR and induces phosphorylation of EGFR at Tyr 1173 in isolated rabbit heart |
EIF4EBP1 | GeneProduct | NP_004086.1 (NCBI Protein) | [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of EIF4EBP1 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells. |
EIF4EBP2 | GeneProduct | NP_004087.1 (NCBI Protein) | [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of EIF4EBP2 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells. |
ELK1 | Protein | NP_001107595.1 (NCBI Protein) | [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of ELK1 in HaCaT cells. |
FAS | Protein | 355 (NCBI Protein) | [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of FAS in HL60 cells |
FASLG | Protein | 356 (NCBI Protein) | [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of FASLG in HL60 cells |
FKBP1A | Protein | NP_000792.1 (NCBI Protein) | [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells |
FOS | Protein | NP_005243.1 (NCBI Protein) | [Pubmed:23062312] have shown that U50,488 stimulates OPRK1 and induces activation of FOS in mice hypothalamic arcuate nucleus neurons. |
FTH1 | Protein | 2498 (Entrez Gene) | [Pubmed: 19244528] have shown that Morphine and DAMGO stimulates OPRM1 and induces upregulation of FTH1 in rat cortical neurons and brain homogenates. |
GALNT1 | Rna | 2589 (NCBI Protein) | [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of GALNT1 in human chondrocytes. |
GATA4 | Protein | 2626 (Entrez Gene) | [Pubmed: 12623878] have shown that Dynorphin stimulatesKOR induces upregulation of GATA4 gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells |
GCK | Protein | 2645 (NCBI Protein) | [Pubmed:16140165] have shown that tramadol stimulates OPRM1 and induces upregulation of GCK in rat cortex and hypothalamus. |
GFAP | Protein | 2670 (NCBI Protein) | [Pubmed: 25806604] have shown that morphine stimulates MOR and induces the upregulation of GFAP in mouse spinal cord. |
GJA1 | Protein | 2697 (NCBI Protein) | [Pubmed:23011166] have shown that U50,488H stimulates KOR and induces upregulation of GJA1 mRNA in rat ventricles. |
GNA12 | Protein | 2768 (Entrez Gene) | [Pubmed:15987828] have shown that DAMGO stimulates MOR and induces upregulation of GNA12 in CHO cells. |
GNAI2 | Protein | 2771 (Entrez Gene) | [Pubmed:15987828] have shown that DAMGO stimulates MOR and induces downregulation of GNAI2 in CHO cells. |
GNAI2 | Protein | NP_002061.1 (NCBI Protein) | [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces association of GNAI2 and RGS12 in a Gbeta/gamma-PI2K-cSRC mediated manner in rabbit cultured smooth muscle cells. |
GNAI2 | Protein | NP_002061.1 (RefSeq) | [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and GNAI2 in mouse PAG synaptosomes |
GNAI3 | Protein | NP_006487.1 (NCBI Protein) | [Pubmed:24976397] have shown that DAMGO, deltorphinII and DPDPE stimulates MOR, MOR-DOR heteromer and DOR respectively and induces activation of GNAI3 in rat striatum and hippocampi |
GNAO1 | Protein | NP_620073.2 (NCBI Protein) | [Pubmed:26119705] have shown that DAMGO stimulates MOR and induces the assciation of OPRM1 and GNAO1 in rat brain membrane. |
GNAZ | Protein | NP_002064.1 (RefSeq) | [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and GNAZ in mouse PAG synaptosomes |
GPX1 | Protein | NP_000572.2 (NCBI Protein) | [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces increased activation of GPX1 in ischemia and reperfusion brain model of rats. |
GRIN1 | GeneProduct | NP_001172020.1 (NCBI Protein) | [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of GRIN1 at S890 in male albino CD1 mice. |
GRIN2A | GeneProduct | NP_000824.1 (NCBI Protein) | [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of GRIN2A at Y1325 in male albino CD1 mice. |
GRIN2B | Protein | NP_000825.2 (NCBI Protein) | [Pubmed: 27634008] have shown that U50488 and Dynorphin stimulates KOR and induces phosphorylation of GRIN2B at Y1472 in mouse primary hippocampus |
GRK2 | Protein | NP_001610.2 (NCBI Protein) | [Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of GRK2 from cytosol to plasma membrane in BE(2)-C cells |
GRK3 | Protein | NP_005151.2 (NCBI Protein) | [Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of GRK3 from cytosol to plasma membrane in BE(2)-C cells |
GSK3B | GeneProduct | NP_002084.2 (NCBI Protein) | [Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of GSK3B at Ser9 in rat nuclear accumbens. |
HDAC1 | Protein | 3065 (Entrez Gene) | [Pubmed:31347026] have shown that morphine stimulates MOR and induces molecular association of OPRM1 and HDAC1 in mouse spinal cord. |
HMOX1 | Protein | 3162 (Entrez Gene) | [Pubmed:30595095] have shown that dynorphin A stimulates KOR and induces upregulation of HMOX1 in rat hippocampal neurons. |
HOMER1 | Rna | 9456 (NCBI Protein) | [Pubmed:20889977] have shown that buprenorphine stimulates MOR induces upregulation of HOMER1 mRNA in rat astrocytic cultures from accumbens. |
HPCA | Rna | 3208 (Entrez Gene) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces upregulation of HPCA in mouse central extended amygdala |
HSPA8 | Protein | 3312 (Entrez Gene) | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of HSPA8 in CHO cells. |
HTR1A | Protein | 3350 (NCBI Protein) | [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of HTR1A in rat dorsal raphe nucleus. |
IFNG | Rna | 3458 (NCBI Protein) | [Pubmed:21801866] have shown that DALDA stimulates MOR and induces downregulation of IFNG in mice colonocytes. |
IGF1R | GeneProduct | NP_000866.1 (NCBI Protein) | [Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of IGF1R at Tyr1135/ Tyr1136 in chinese hamster cells. |
IL1B | Rna | 3553 (NCBI Protein) | [Pubmed:21801866] have shown that DALDA stimulates MOR and induces downregulation of IL1B in mouse colonocytes. |
IL4 | Rna | 3565 (NCBI Protein) | [Pubmed:23965172] have shown that morphine/methadone stimulate OPRM1 and induces up regulation of IL4 in a AP1 and NFAT dependent manner in human T-lymphocytes. |
IL6 | Rna | 3569 (NCBI Protein) | [Pubmed:21801866] have shown that DALDA stimulates MOR and induces downregulation of IL6 in mouse colonocytes. |
IRS2 | Protein | 8660 (NCBI Protein) | [Pubmed:16140165] have shown that tramadol stimulates OPRM1 and induces upregulation of IRS2 in rat primary neuronal cells. |
ITGAM | Protein | 3684 (NCBI Protein) | [Pubmed:23844255] have shown that TAN-67 stimulates DOR and induces downregulation of ITGAM in rat cortex. |
JUN | GeneProduct | NP_002219.1 (NCBI Protein) | [Pubmed:16249373] have shown that DADLE stimulates DOR and induces phosphorylation of JUN at Ser63 in an AKT dependent manner in mouse splenocytes. |
JUP | Protein | 3728 (Entrez Gene) | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of JUP in CHO cells. |
KDR | Protein | 3791 (NCBI Protein) | [Pubmed:21460241] have shown that U-50,488H/TRK820 stimulates KOR and induces Gi/cAMP/PKA mediated downregulation of KDR in mouse endothelial cels. |
KDR | GeneProduct | NP_002244.1 (NCBI Protein) | [Pubmed:16918381] have shown that morphine stimulates MOR and induces phosphorylation of KDR at Y1212 in mouse retinal endothelial cells. |
KRAS | Protein | NP_004976.2 (NCBI Protein) | [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of KRAS in HEK293 cells |
MAP1LC3B | Protein | 81631 (Entrez Gene) | [Pubmed:32955950] have shown that BW373U86 stimulates DOR and induces upregulation of MAP1LC3B in hypoxic rat cardiomyocytes. |
MAP2K1 | Protein | NP_002746.1 (NCBI Protein) | [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAP2K1 in a RAF1 dependent manner in HEK293 cells |
MAPK14 | Protein | NP_001306.1 (NCBI Protein) | [Pubmed:10501195] have shown that DPDPE or N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK14 at Thr 180 /Tyr 182 in a PKA dependent manner in NG108-15 cells. |
MAPK1 | Protein | NP_002736.3 (NCBI Protein) | [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK1 at Thr185 and Tyr187 in a PKC dependent manner in NG108-15 cells. |
MAPK3 | Protein | NP_002736.3 (NCBI Protein) | [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK3 at Thr202 and Tyr204 in a PKC dependent manner in NG108-15 cells |
MAPK8 | Protein | NP_001265476.1 (NCBI Protein) | [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK8 at Tyr 185 in mouse spinal cord. |
MAPK9 | Protein | NP_002743.3 (NCBI Protein) | [Pubmed:26056051] have shown that morphine and fentanyl stimulate OPRM1 and induce activation of MAPK9 in a Src-PKC dependent and GRK3-ARBB2, Src dependent manner respectively in C57Bl/6 mice |
MAPK9 | GeneProduct | NP_620709.1 (NCBI Protein) | [Pubmed: 25806604] have shown that moprhine stimulates MOR and induces phosphorylation of MAPK9 at Y185 in mosue spinal glial cells |
MBP | Protein | 4155 (Entrez Gene) | [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce upregulation of MBP downstream of MAPK14 in NG108-15 cells. |
MBP | Protein | 4155 (NCBI Protein) | [Pubmed:22002899] have shown that methadone/Buprenorphine stimulates MOR and induces upregulation of MBP in rat oligodendrocytes. |
MCL1 | Protein | 4170 (NCBI Protein) | [Pubmed:22033345] have shown that methadone/Buprenorphine stimulates MOR and induces upregulation of MCL1 in rat oligodendrocytes. |
MIR190A | Rna | 460965 (Entrez Gene) | [Pubmed:19854889] have shown that fentanyl stimulates MOR and induces downregulation of MIR190A in rat hippocampal neurons. |
MMP2 | Protein | 4313 (NCBI Protein) | [Pubmed:26763532] have shown that leucin enkephalin stimulates DOR and induces upregulation of MMP2 in HaCaT cells. |
MMP9 | Protein | 4318 (NCBI Protein) | [Pubmed:26763532] have shown that leucin enkephalin stimulates DOR and induces upregulation of MMP9 in HaCaT cells. |
MTOR | Protein | NP_004949.1 (NCBI Protein) | [Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of MTOR at Ser2448 in HEK293 cells ina PI3K-AKT1 dependent manner. |
MYC | Rna | 4609 (NCBI Protein) | [Pubmed:21801866] have shown that DALSA stimulates MOR and induces upregulation of MYC in CMT-93 cells |
NCAM1 | Protein | 4684 (NCBI Protein) | [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of NCAM1 in a STAT5B mediated manner in Neuro 2A cells. |
NEU2 | Protein | 4759 (Entrez Gene) | [Pubmed:15987828] have shown that morphine stimulates MOR and induces downregulation of NEU2 in CHO cells. |
NEUROD1 | Protein | 4790 (NCBI Protein) | [Pubmed:20554861] have shown that fentanyl stimulates MOR and induces upregulation of NEUROD1 in rat hippocampal neurons. |
NFE2L2 | GeneProduct | NP_006155.2 (NCBI Protein) | [Pubmed:30595095] have shown that dynorphin A stimulates OPRK1 and induces translocation of NFE2L2 from cytosol to nucleus in rat hippocampal neurons. |
NISCH | Protein | NP_009115.2 (NCBI Protein) | [Pubmed: 26363797] have shown that DAMGO stimulates MOR and induces molecular association of OPRM1 and NISCH in CHO cells |
NKX2-5 | Protein | 1482 (NCBI Protein) | [Pubmed: 12623878] have shown that Dynorphin stimulates OPRM1 induces upregulation of NKX2-5 gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells |
NLRP1 | Complex | NP_127497.1 (NCBI Protein) | [Pubmed:26162710] have shown that morphine stimulates MOR and induces molecular association of cleaved CASP1-PYCARD-NLRP1 in a PI3K/AKT dependent manner leading to the formation of an inflammasome complex in rat primary spinal neurons. |
NOS1 | GeneProduct | NP_001191147.1 (NCBI Protein) | [Pubmed:21348811] have shown that morphine stimulates MOR induces association of OPRM1 and NOS1 in mouse PAG synaptosomes. |
NOS2 | GeneProduct | 4843 (Entrez Gene) |
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NOS3 | Protein | NP_000594.2 (NCBI Protein) |
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NOTCH1 | Protein | 4851 (NCBI Protein) | [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of NOTCH1 in mouse spinal cord |
NRN1 | Rna | 51299 (NCBI Protein) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces downregulation of NRN1 in mouse central extended amygdala |
NRP1 | Protein | 8829 (NCBI Protein) | [Pubmed:21460241] have shown that U-50,488H/TRK820 stimulates KOR and induces Gi/cAMP/PKA mediated downregulation of NRP1 in mouse endothelial cels. |
NTRK2 | Protein | 4915 (NCBI Protein) | [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of NTRK2 in rat dorsal raphe nucleus. |
OPRD1 | Protein | NP_000902.3 (NCBI Protein) |
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OPRK1 | Protein | NP_001305426.1 (NCBI Protein) |
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OPRL1 | Protein | 4987 (Entrez Gene) | [Pubmed:16311589] have shown that nociceptin stimulates ORL1 and induces translocation of OPRL1-CACNA1B complex from cell membrane to cytosol in CHO cells and rat DRG neurons. |
OPRL1 | Protein | NP_001305782.1 (NCBI Protein) | [Pubmed: 10334841] have shown that Nociceptin stimulates OPRL1 and induces activation of OPRL1 in CHO-K1 cells |
OPRM1 | GeneProduct | [Pubmed:31347026] have shown that morphine stimulates MOR and induces translocation of OPRM1 from plasma membrane to cytosol in mouse spinal cord. | |
OPRM1 | GeneProduct | 4988 (Entrez Gene) | |
OPRM1 | Protein | NP_001138751.1 (NCBI Protein) | [Pubmed:24061856] have shown that morphine stimulates MOR and induces phosphorylation of OPRM1 at Tyr336 in HEK293 cells. |
P2RX4 | Protein | 5025 (NCBI Protein) | [Pubmed:19176808] have shown that morphine stimulates MOR and induces upregulation of P2RX4 in rat microglia. |
PCNA | Protein | 511 (Entrez Gene) | [Pubmed:16697745] have shown that DAMGO stimulates MOR and induces upregulation of PCNA in BDL rat cholangiocytes. |
PDGFRB | GeneProduct | NP_002600.1 (NCBI Protein) | [Pubmed:16918381] have shown that morphine stimulates MOR and induces phosphorylation of PDGFRB at Y716 in mouse retinal endothelial cells. |
PDK1 | GeneProduct | NP_001265478.1 (NCBI Protein) | [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells |
PDYN | Protein | 5173 (NCBI Protein) | [Pubmed: 12623878] have shown that Dynorphin stimulates KOR induces upregulation of PDYN gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells |
PGM1 | Protein | 5236 (Entrez Gene) | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of PGM1 in CHO cells. |
PIK3CG | GeneProduct | 5294 (Entrez Gene) | [Pubmed:24654606] have hown that morphine stimulates MOR and induces activation of PIK3CG in SK-N-LO cells and mouse sensory neurons |
PIK3R1 | Protein | 5295 (NCBI Protein) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces upregulation of PIK3R1 in mouse central extended amygdala |
PLCB3 | GeneProduct | NP_000923.1 (NCBI Protein) |
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PLD2 | GeneProduct | NP_002654.3 (NCBI Protein) | Pubmed:16539674] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively and induces activation of PLD2 in an ARF-GTP dependent manner in HEK293 cells |
PLEKHG1 | Rna | 57480 (Entrez Gene) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces downregulation of PLEKHG1 in mouse central extended amygdala |
PPP3CA | Protein | NP_000935.1 (NCBI Protein) | [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells |
PRG4 | Protein | 10216 (NCBI Protein) | [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of PRG4 in a cAMP/PKA alpha/CREB dependent manner in human chondrocytes. |
PRKCA | Protein | NP_002728.1 (NCBI Protein) | [Pubmed:16697745] have shown that DPDPE stimulates DOR and induces PRKCA phosphorylation at Ser 657 in rat BDL cholangiocytes |
PRKCE | Protein | 5581 (Entrez Gene) | [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of PRKCE in mouse spinal cord. |
PRKCE | Protein | NP_005391.1 (NCBI Protein) | [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of PRKCE at Ser 729 in mouse spinal cord. |
PRKCG | Protein | 5582 (Entrez Gene) | [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of PRKCG in mouse spinal cord. |
PRKCG | Protein | NP_001303258.1 (NCBI Protein) | [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of PRKCG at Thr 512 in mouse spinal cord. |
PRKCZ | GeneProduct | NP_002735.3 (NCBI Protein) | [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells |
PRKCZ | GeneProduct | NP_005154.2 (NCBI Protein) |
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PTGDS | Rna | 5730 (NCBI Protein) | [Pubmed:18591478] have shown that morphine stimulates MOR and induces upregulation of PTGDS in mouse lateral hypothalamus. |
PTGS2 | Rna | 5743 (NCBI Protein) | [Pubmed:21801866] have shown that DALDA stimulates MOR and induces upregulation of PTGS2 in CMT-93 cells |
PTK2B | Protein | NP_775266.1 (NCBI Protein) | [Pubmed:10646507] have shown that stimulation of OPRK1 with U69,593 induces Tyr phosphorylation of PTK2B in C6 glioma cell line |
PTK2 | Protein | NP_001339623.1 (NCBI Protein) | [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of PTK2 at Y397 in THP1 and COS7 cells. |
PYCARD | Complex | NP_037390.2 (NCBI Protein) | [Pubmed:26162710] have shown that morphine stimulates MOR and induces molecular association of cleaved CASP1-PYCARD-NLRP1 in a PI3K/AKT dependent manner leading to the formation of an inflammasome complex in rat primary spinal neurons. |
Phosphatidic acid synthesis | Metabolite | ||
RAC1 | GeneProduct | 5879 (Entrez Gene) | [Pubmed: 27634008] have shown that U50488 stimulate KOR and induces the downregulation of RAC1 in mouse hippocampus |
RAC1 | Protein | NP_061485.1 (NCBI Protein) | [Pubmed:15056283] have shown that DAMGO stimulates MOR and induces activation of RAC1 in SHSY5Y and COS7 cells. |
RAF1 | Protein | NP_001341618.1 (NCBI Protein) |
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RAMP3 | Rna | 10268 (NCBI Protein) | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces downregulation of RAMP3 in mouse central extended amygdala |
REG3A | Rna | 5068 (NCBI Protein) | [Pubmed:21801866] have shown that DALDA stimulates MOR and induces upregulation of REG3A in CMT-93 cells |
RELA | Protein | 5970 (Entrez Gene) | [Pubmed:23402995] have shown that U50,488H stimulates OPRK1 and induces downregulation of RELA in Male Sprague Dawley rat myocardial infarction and reperfusion heart model. |
RGS12 | Protein | NP_937872.1 (NCBI Protein) | [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces association of GNAI2 and RGS12 in a Gbeta/gamma-PI2K-cSRC mediated manner in rabbit cultured smooth muscle cells. |
RGS17 | GeneProduct | NP_036551.3 (NCBI Protein) | [Pubmed:21348811] have shown that morphine stimulates MOR induces association of activated NOS1 and RGS17 in mouse PAG synaptosomes. |
RGS4 | Protein | 5999 (Entrez Gene) | [Pubmed: 22056472] have shown that morphine stimulates MOR and induces upregulation of RGS4 in rat prefrontal cortex. |
RGS4 | Protein | NP_001095915.1 (NCBI Protein) | [Pubmed:26119705] have shown that DAMGO stimulates MOR and induces the assciation of RGS4 and OPRM1 in rat brain membrane. |
RGS9 | Protein | 8787 (Entrez Gene) | [Pubmed:24561386] have shown that morphine stimulates MOR and induces downregulation of RGS9 in mouse D2-type neurons. |
RGS9 | Protein | NP_001075424.1 (RefSeq) | [Pubmed:15632124] have shown that morphine stimulates MOR and induces phosphorylation of RGS9 at S475 in mouse PAG synaptosomes |
RPLP2 | Protein | 6181 (Entrez Gene) | [Pubmed:15987828] have shown that morphine stimulates MOR and induces downregulation of RPLP2 in CHO cells. |
RPS6KA1 | Protein | NP_002944.2 (NCBI Protein) | [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of RPS6KA1 in HaCaT cells. |
RPS6KB1 | GeneProduct | NP_003152.1 (NCBI Protein) | [Pubmed: 9224649] have shown that DADLE stimulates OPRD1 and induces activation of RPS6KB1 in a Gi/G0, PI3K and FRAP/RAFT dependent manner in D2 cells. |
RSG4 | Rna | 5999 (NCBI Protein) | [Pubmed:18591478] have shown that morphine stimulates MOR and induces downregulation of RGS4 in mouse lateral hypothalamus. |
SGK1 | Rna | 6446 (NCBI Protein) | [Pubmed:18591478] have shown that morphine stimulates MOR and induces upregulation of SGK1 in mice lateral hypothalamus. |
SLC1A2 | Protein | 6506 (NCBI Protein) | [Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces upregulation of SLC1A2 protein in mouse astrocyte cultures |
SLC1A3 | Protein | 6507 (NCBI Protein) | [Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces upregulation of SLC1A3 protein in mouse astrocyte cultures |
SLC6A3 | Protein | NP_001035.1 (NCBI Protein) |
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SLC6A4 | Protein | NP_001036.1 (NCBI Protein) | [Pubmed:25107591] have shown that SalA stimulates KOR and induces activation of SLC6A4 in EM4 cells |
SLC9A1 | Rna | 6548 (Entrez Gene) | [Pubmed: 10665987] have shown that U50,488H stimulates KOR induces the upregulation of SLC9A1 in a PKC dependent manner in heart from Male Sprague Dawley rat |
SOD1 | Protein | NP_000445.1 (NCBI Protein) | [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces increased activation of SOD1 in ischemia and reperfusion brain model of rats. |
SP1 | Protein | NP_612482.2 (NCBI Protein) | [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and SP1 in CEMx174 cells. |
SQSTM1 | Protein | 8878 (Entrez Gene) | [Pubmed:32955950] have shown that BW373U86 stimulates DOR and induces downregulation of SQSTM1 in hypoxic rat cardiomyocytes. |
SRC | Protein | NP_005408.1 (NCBI Protein) | Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of SRC at Tyr416 in HEK293 cells. |
STAT3 | GeneProduct | NP_003141.2 (NCBI Protein) | [Pubmed:23996400] have shown that BRL52537 stimulates KOR and induces phosphorylation of STAT3 at Y705 in ischemia reperfused rat hippocampal CA1 region. |
STAT5B | GeneProduct | NP_036580.2 (NCBI Protein) | [Pubmed:23906478] have shown that DSLET stimulates DOR and induces phosphorylation of STAT5B at Y699 in a G alpha i/0 dependent manner in Neuro 2A cells |
SYP | Protein | 6855 (NCBI Protein) | [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of SYP in a STAT5B mediated manner in Neuro 2A cells. |
SYT1 | Rna | 6857 (NCBI Protein) | [Pubmed:20889977] have shown that buprenorphine stimulates MOR induces upregulation of SYT1 mRNA in rat astrocytic cultures from accumbens. |
THBS1 | Rna | 7057 (NCBI Protein) | [Pubmed:20889977] have shown that buprenorphine/morphine stimulates MOR induces downregulation of THBS1 mRNA in rat astrocytic cultures from accumbens. |
TLR4 | Protein | 7099 (Entrez Gene) | [Pubmed:23402995] have shown that U50,488H stimulates OPRK1 and induces downregulation of TLR4 in Male Sprague Dawley rat's myocardial infarction and reperfusion heart model. |
TNF | Protein | 7124 (Entrez Gene) |
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TNF | Rna | 7124 (NCBI Protein) | [Pubmed:21801866] have shown that DALDA stimulates MOR and induces downregulation of TNF in mouse colonocytes. |
TRPM8 | Protein | NP_076985.4 (NCBI Protein) | [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells. |
TUBB | Protein | 203068 (Entrez Gene) | [Pubmed:15987828] have shown that morphine stimulates MOR and induces upregulation of TUBB in CHO cells. |
TUBB3 | Protein | 10381 (NCBI Protein) | [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of NCAM1 in a STAT5B mediated manner in Neuro 2A cells. |
UBQLN1 | Protein | 29979 (NCBI Protein) | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of UBQLN1 in CHO cells. |
WLS | Protein | NP_001002292.3 (NCBI Protein) | [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells. |
XYLT1 | Rna | 64131 (NCBI Protein) | [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of XYLT1 in human chondrocytes. |
YWHAQ | Protein | NP_006817.1 (RefSeq) | [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and YWHAQ in mouse PAG synaptosomes |
YY1 | Protein | NP_003394.1 (NCBI Protein) | [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and YY1 in CEMx174 cells. |
Annotated Interactions
No annotated interactions