Th17 cell differentiation pathway (Homo sapiens)

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2NucleusSOCS31, 31, 3DAG3-PIP3+PAHr LigandDNACa2+IL1BIRF4IL22HIF1ATGFBR1IL6IL23RJAK1/3RORAIL6RIL21PLCG1RORCIL23RIL1BRMAPK14HLA-DMAMTORTGFB1JAK1IL23AIL21RTYK2JAK2HSP90AA1STAT3SMADsAHRDNAIRF4RORARORCDNAIL21IL17AIL17FDNAHIF1ADNANFKBIAJUNFOSNFKB1NFATC1JNKERKPRKCQZAP70LCKCD3ZIL4RIL4LATCD3ECD3DTCRBTCRACD3GCD3ECD4JAK1/3CD3ZMAPK14STAT6CaNIKKAntigen+P+PGATA3TBX21RUNX1FOXP3RXRARARASTAT5ASTAT1IL2RIFNGRIL2IFNGIL27RIL27TYK2JAK2JAK2JAK1/3TGFBR1TGFB1SMAD2ATRADNADNATBX21RUNX1DNAGATA3NFIL3CRY1PER1NR1D1BMAL1CLOCKDNACRY1PER1


Description

Th17 Cell differentiation and the effect of circadian network. The differentiation pathway for Th17 cell is considered and converted from the KEGG pathways database, whereas its connection with the circadian network is taken from the literature. All the references will be provided soon.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Chang, Fang-Chen; ''A Dual Role for REV-ERB alpha in Th17 Cell Mediated Immune Response''; University of California, San Diego [PhD thesis], 2016
  2. Tsai, Chi-Hao and Lee, Yi and Li, Ching-Hao and Cheng, Yu-Wen and Kang, Jaw-Jou; ''Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling''; Cell biology and toxicology, 2020 PubMed Europe PMC Scholia
  3. Sutton, Caroline E, Finlay, Conor M, Raverdeau, Mathilde, Early, James O, DeCourcey, Joseph, Zaslona, Zbigniew, O’Neill, Luke AJ, Mills, Kingston HG, Curtis, Annie M; ''Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease''; Nature communications, 2017 PubMed Europe PMC Scholia
  4. Chen, Wei, Nyuydzefe, Melanie S, Weiss, Jonathan M, Zhang, Jingya, Waksal, Samuel D, Zanin-Zhorov, Alexandra; ''ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells''; Scientific reports, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134675view21:33, 25 July 2024EweitzUse gene symbols
134672view21:19, 25 July 2024EweitzUse gene symbols
134663view12:00, 25 July 2024EweitzEconomize layout
134662view11:49, 25 July 2024EweitzEconomize layout
134661view11:46, 25 July 2024EweitzEconomize nucleus
128044view12:45, 22 January 2024EweitzModified description
126092view01:22, 5 April 2023HafeezTh17 cell differentiation and circadian rhythm
125323view22:13, 31 January 2023LarsgwFix reference bp:DB
125018view19:34, 13 January 2023EgonwCorrect HGNC Accession number data source
123523view06:03, 1 August 2022EgonwMoved two KEGG pathway identifiers to the comment as they are not reaction identifiers
123517view20:05, 31 July 2022EgonwMoved KEGG pathway identifiers to the comment as they are not reaction identifiers
122780view04:45, 17 May 2022HafeezLinks are straight and more clear for articals
121321view23:41, 14 February 2022KhanspersOntology Term : 'immune response pathway' added !
121320view23:39, 14 February 2022KhanspersOntology Term : 'signaling pathway' added !
120874view07:47, 24 January 2022HafeezCrosstalk between Circadian Rhythm and Th17 Cell Differentiation
120873view07:41, 24 January 2022HafeezCrosstalk between Circadian Rhythm and Th17 cell differentiation
120867view15:49, 22 January 2022HafeezAnnotation and cross talk added
120442view20:38, 2 December 2021Khanspersconnected interactions, updated cleavage of NFKB1 from NFKB1A
120441view20:31, 2 December 2021KhanspersOntology Term : 'T-helper 17 cell' added !
120223view07:15, 15 November 2021EgonwNot mim conversions
119802view11:21, 25 August 2021HafeezModified description
119794view15:04, 24 August 2021Hafeezsome new interactions are added and the pathway is curated in an well organized way
119774view11:37, 20 August 2021HafeezModified description
119773view11:32, 20 August 2021HafeezNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AHRGeneProductENSG00000106546 (Ensembl)
BMAL1GeneProductENSG00000133794 (Ensembl)
CD3DGeneProductENSG00000167286 (Ensembl)
CD3EGeneProductENSG00000198851 (Ensembl)
CD3GGeneProductENSG00000160654 (Ensembl)
CD3ZGeneProductENSG00000198821 (Ensembl)
CD4GeneProductENSG00000010610 (Ensembl)
CLOCKGeneProductENSG00000134852 (Ensembl)
CRY1GeneProductENSG00000008405 (Ensembl)
CaNGeneProductENSG00000138814 (Ensembl)
ERKGeneProductENSG00000100030 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
FOXP3GeneProductENSG00000049768 (Ensembl)
GATA3GeneProductENSG00000107485 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HLA-DMAGeneProductENSG00000204257 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl) Hsp90
IFNGGeneProductENSG00000111537 (Ensembl)
IFNGRGeneProductENSG00000027697 (Ensembl)
IKKGeneProductENSG00000104365 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17FGeneProductENSG00000112116 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1BRGeneProductENSG00000125538 (Ensembl)
IL21GeneProductENSG00000138684 (Ensembl)
IL21RGeneProductENSG00000103522 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL23AGeneProductENSG00000110944 (Ensembl)
IL23RGeneProductENSG00000162594 (Ensembl)
IL27GeneProductENSG00000197272 (Ensembl)
IL27RGeneProductENSG00000104998 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL2RGeneProductENSG00000134460 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL4RGeneProductENSG00000077238 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
IRF4GeneProductENSG00000137265 (Ensembl)
JAK1/3GeneProductENSG00000162434 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LATGeneProductENSG00000213658 (Ensembl)
LCKGeneProductENSG00000182866 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl) p38
MTORGeneProductENSG00000198793 (Ensembl)
NFATC1GeneProductENSG00000131196 (Ensembl)
NFIL3GeneProductENSG00000165030 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NR1D1GeneProductENSG00000126368 (Ensembl) Rev-erb
PER1GeneProductENSG00000179094 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RARAGeneProductENSG00000131759 (Ensembl)
RORAGeneProductENSG00000069667 (Ensembl)
RORCGeneProductENSG00000143365 (Ensembl) RORgt
RUNX1GeneProductENSG00000159216 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMADsGeneProductENSG00000175387 (Ensembl)
SOCS3GeneProductENSG00000184557 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)
TBX21GeneProductENSG00000073861 (Ensembl) T-bet
TCRAGeneProduct12027 (HGNC Accession number)
TCRBGeneProduct12155 (HGNC Accession number)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)
ZAP70GeneProductENSG00000115085 (Ensembl)

Annotated Interactions

No annotated interactions

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