mRNA vaccine activation of dendritic cell and induction of IFN-1 (Homo sapiens)
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Description
After uptake, mRNA is translated into spike protein and presented as cell-surface MHC-bound peptides to CD4+ and CD8+ T cells. Cytosolic sensing of RNA by RIG-I and MDA5 plus TLR binding within endosomes leads to activation of IFN regulatory factor 3/7 (IRF3/7) and nuclear factor κB (NF-κB), which bind to DNA inducing gene transcription, and production of IFN-I and proinflammatory cytokines, respectively
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Ontology Terms
Saving...Bibliography
- Sprent J, King C; ''COVID-19 vaccine side effects: The positives about feeling bad.''; Sci Immunol, 2021 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| Cellular immunity | |||
| Humoral immunity | |||
| IFN-1 receptor | Protein | ||
| IRF-7 | Protein | Q92985 (Uniprot-TrEMBL)  | |
| IRF3 | Protein | Q14653 (Uniprot-TrEMBL) | |
| ISRE | |||
| MAVS | Protein | Q7Z434 (Uniprot-TrEMBL) | |
| MDA5 | Protein | Q9BYX4 (Uniprot-TrEMBL) | |
| NF-kB | Protein | Q9Y6Q6 (Uniprot-TrEMBL) | |
| Proinflammatory cytokine genes | |||
| Proinflammatory cytokines | GeneProduct | ||
| RIG-I (DDX58) | Protein | O95786 (Uniprot-TrEMBL) | |
| S peptide presentation | Protein | Q95460 (Uniprot-TrEMBL) | |
| SARS-CoV 2 mRNA | Rna | ||
| Spike Protein | Protein | P0DTC2 (Uniprot-TrEMBL) | |
| T cell receptor | Protein | P01848 (Uniprot-TrEMBL) | |
| TLR3 | Protein | O15455 (Uniprot-TrEMBL) | |
| TLR7 | Protein | Q9NYK1 (Uniprot-TrEMBL) | |
| TLR8 | Protein | Q9NR97 (Uniprot-TrEMBL) | |
| Type 1 IFNs | GeneProduct |
Annotated Interactions
No annotated interactions
