HINT1 Pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NFκB1AP1 complexNFATC2FOSJUNTCF4CTNNB1cyclin HCDK7TFIIH complexMAT1TF2H5TF2H3TF2H2TF2H4TF2H1ERCC3ERCC2tRNA AminoacylationKARS1Guanosine 5'-monophosphorothioate5'-AMPHINT1Guanosine 5'-monophosphorothioateUSF2MITF3'-lysyl-AMPATPlysineHINT1SH3RF1MAPK9ATP-sensitive potassium channels pathwaySRUVB2RUVB1RUVB2RUVB1AP1 complexNFATC2FOSJUNPName: HINT1 PathwayOrganism: Homo sapiens


Description

HINT1 is a protein that can be mutated in CMT disease.

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Bibliography

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  1. Wang J, Fang P, Schimmel P, Guo M; ''Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor.''; J Phys Chem B, 2012 PubMed Europe PMC Scholia
  2. Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB; ''Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  3. Martin J, St-Pierre MV, Dufour JF; ''Hit proteins, mitochondria and cancer.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  4. Wang L, Li H, Zhang Y, Santella RM, Weinstein IB; ''HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells.''; Int J Cancer, 2009 PubMed Europe PMC Scholia
  5. Peeters K, Chamova T, Tournev I, Jordanova A; ''Axonal neuropathy with neuromyotonia: there is a HINT.''; Brain, 2017 PubMed Europe PMC Scholia
  6. Ozga M, Dolot R, Janicka M, Kaczmarek R, Krakowiak A; ''Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5'-O-phosphorothioates to nucleoside 5'-O-phosphates.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  7. Weiske J, Huber O; ''The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription.''; J Cell Sci, 2005 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
138130view13:15, 17 March 2025Julen van HamNew pathway

External references

DataNodes

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Name  ↓Type  ↓Database reference  ↓Comment  ↓
3'-lysyl-AMPMetaboliteCHEBI:131569 (ChEBI)
5'-AMPMetaboliteCHEBI:16027 (ChEBI)
AP1 complexComplexCPX-480
ATP-sensitive potassium channels pathwayPathwayWP2669 (WikiPathways)
ATPMetaboliteCHEBI:30616 (ChEBI)
CDK7GeneProductENSG00000134058 (Ensembl)
CTNNB1GeneProductP35222 (Uniprot-TrEMBL)
ERCC2GeneProductP18074 (Uniprot-TrEMBL)
ERCC3GeneProductP19447 (Uniprot-TrEMBL)
FOSGeneProductP01100 (Uniprot-TrEMBL)
Guanosine 5'-monophosphorothioateMetabolite135405922 (PubChem-compound)
HINT1GeneProductENSG00000169567 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
KARS1GeneProductENSG00000065427 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAT1GeneProductP51948 (Uniprot-TrEMBL)
MITFGeneProductENSG00000187098 (Ensembl)
NFATC2GeneProductQ13469 (Uniprot-TrEMBL)
NFκB1GeneProductP19838 (Uniprot-TrEMBL)
RUVB1GeneProductQ9Y265 (Uniprot-TrEMBL)
RUVB2GeneProductQ9Y230 (Uniprot-TrEMBL)
SH3RF1GeneProductENSG00000154447 (Ensembl)
TCF4GeneProductP15884 (Uniprot-TrEMBL)
TF2H1GeneProductP32780 (Uniprot-TrEMBL)
TF2H2GeneProductQ13888 (Uniprot-TrEMBL)
TF2H3GeneProductQ13889 (Uniprot-TrEMBL)
TF2H4GeneProductQ92759 (Uniprot-TrEMBL)
TF2H5GeneProductQ6ZYL4 (Uniprot-TrEMBL)
TFIIH complexComplexCPX-2395
USF2GeneProductENSG00000105698 (Ensembl)
cyclin HGeneProductP51946 (Uniprot-TrEMBL)
lysineMetaboliteCHEBI:25094 (ChEBI)
tRNA AminoacylationPathwayWP1938 (WikiPathways)

Annotated Interactions

No annotated interactions

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