Hypothetical network for drug addiction (Gallus gallus)

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1MAPK signaling pathwayAMPARRegulation of actin cytoskeletonStrong depolarizationRegulation of gap junctionGnRH Signal pathwayNeuroactive ligand-receptorinteractionLong-term potentiationmGluRLocal TranslationGonadotropins gene expression & secretionNMDARGap junctionDRD2GRM1GRIN2BADCY1GRIA3PKAPRKCECAMK4GRIA2GRM5DRD1DRD4MAPK1GRIN2ANISCHZHX2D-GlutamateCyclic AMPMAP2K1ADCY8GRIA4GsTERF2IPGiGRIN1PKAGRIN2CconnexinERK1GRIN2DCAMK2KRIT1CREB1connexinACTA1GRIA1ADCY1PPA1MAP2K2Ca++


Description

Adapted from figure 2 in Li et al..

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 70% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118082view10:44, 24 May 2021EweitzModified title
107107view14:18, 17 September 2019MaintBotChEBI identifier normalization
102313view13:35, 18 December 2018EgonwFixed the ChEBI identifier for Ca2+
88658view15:15, 12 August 2016JmeliusOntology Term : 'substance dependence disease pathway' added !
68878view17:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
41019view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
33940view18:13, 9 December 2009MaintBotAutomatic update of empty xrefs
33447view14:59, 30 November 2009MaintBotRemoved group label
31502view21:33, 13 August 2009MaintBotFixed text labels
30333view20:47, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA1GeneProduct421534 (Entrez Gene)
ADCY1GeneProduct420788 (Entrez Gene)
ADCY8GeneProduct420328 (Entrez Gene)
CAMK2GeneProduct
CAMK4GeneProduct723973 (Entrez Gene)
CREB1GeneProduct395099 (Entrez Gene)
Ca++MetaboliteCHEBI:29108 (ChEBI)
Cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
D-GlutamateMetaboliteCHEBI:15966 (ChEBI)
DRD1GeneProduct427633 (Entrez Gene)
DRD2GeneProduct428252 (Entrez Gene)
DRD4GeneProduct423016 (Entrez Gene)
ERK1GeneProduct
GRIA1GeneProduct414893 (Entrez Gene)
GRIA2GeneProduct414894 (Entrez Gene)
GRIA3GeneProduct396138 (Entrez Gene)
GRIA4GeneProduct396137 (Entrez Gene)
GRIN1GeneProduct404296 (Entrez Gene)
GRIN2AGeneProduct427678 (Entrez Gene)
GRIN2BGeneProduct417965 (Entrez Gene)
GRIN2CGeneProduct
GRIN2DGeneProduct
GRM1GeneProduct421614 (Entrez Gene)
GRM5GeneProduct373933 (Entrez Gene)
GiGeneProduct
GsGeneProduct
KRIT1GeneProduct420549 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
NISCHGeneProduct415893 (Entrez Gene)
PKAGeneProduct
PPA1GeneProduct769424 (Entrez Gene)
PRKCEGeneProduct421409 (Entrez Gene)
TERF2IPGeneProduct395122 (Entrez Gene)
ZHX2GeneProduct420351 (Entrez Gene)
connexinGeneProduct

Annotated Interactions

No annotated interactions
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