Apoptosis (Gallus gallus)

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351CaspActivator of Cell DeathpFas LigandpApoptosisDNA FragmentationDegradationbbeMitochondrionIGF1R signaling pathwaybInterferon regulatory factorsep53 RelatedInhibitor of Cell DeathMIR29B1MIR29APMAIP1CASP9MDM2BAK1TRAF3IRF1NFKB1FASBIRC2DIABLOAKT1GZMBTNFRSF21BADNFKBIACASP1RIPK1IRF2NFKBIBLTACASP4IRF6CASP3PRF1TNFRSF1AIGF1RRELACHUKBAXAPAF1TNFRSF1BCASP10BIRC3BIDTNFRSF25MAPK10TRAF1IKBKBIRF5DFFACYCSNFKBIBBBC3IRF3CASP2HRKTP73SCAF11CASP7MYCTNFIGF2CRADDIKBKGBOKTRAF2CFLARBCL2L2PIK3R1TRADDBIRC5IGF-ITNFRSF10BJUNBNIP3LCADTRADDBCL2TNFRSF1AIRF7RELABCL2L1IRF4NFKBIETP534MAP2K4RIPK1CDKN2ACASP8BIRC4BADNFKBIATNFSF6TNFSF10NFKBIEHELLSNFKB1FADDMCL1CASP6BCL2L11MAP3K1TP63MIR29B2


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP254 (r95107) with a 83.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia
  2. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia
  3. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  4. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  5. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95787view14:37, 19 January 2018MkutmonHomology conversion update
67051view09:59, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
62332view16:49, 27 April 2013EgonwOnly move MDM2.
62331view16:48, 27 April 2013EgonwUndo revision 62330 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
62330view16:46, 27 April 2013EgonwMoved MDM2 and did an undo.
48121view05:10, 9 May 2012KhanspersUpdating from human to fix xref duplication
47795view16:34, 6 April 2012Khanspersupdated xref
41016view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
33937view18:12, 9 December 2009MaintBotAutomatic update of empty xrefs
33465view15:03, 30 November 2009MaintBotRemoved group label
30356view20:54, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSGALG00000011620 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:207
APAF1GeneProductENSGALG00000011531 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:317
BADGeneProductNo homologues found for original id L:572
BAK1GeneProductENSGALG00000031493 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:578
BAXGeneProductNo homologues found for original id L:581
BBC3GeneProductNo homologues found for original id L:27113
BCL2GeneProductENSGALG00000012885 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:596
BCL2L11GeneProductNo homologues found for original id L:10018
BCL2L1GeneProductENSGALG00000006211 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:598
BCL2L2GeneProductNo homologues found for original id L:599
BIDGeneProductENSGALG00000013039 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:637
BIRC2GeneProductENSGALG00000017186 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:329
BIRC3GeneProductENSGALG00000017186 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:330
BIRC4GeneProductENSGALG00000008491 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:331
BIRC5GeneProductENSGALG00000008713 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:332
BNIP3LGeneProductENSGALG00000043405 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:665
BOKGeneProductENSGALG00000005772 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:666
CADGeneProductENSGALG00000036295 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1677
CASP10GeneProductENSGALG00000046494 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:843
CASP1GeneProductENSGALG00000001049 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:834
CASP2GeneProductENSGALG00000014698 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:835
CASP3GeneProductENSGALG00000010638 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:836
CASP4GeneProductENSGALG00000001049 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:837
CASP6GeneProductENSGALG00000012186 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:839
CASP7GeneProductENSGALG00000008933 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:840
CASP8GeneProductENSGALG00000008355 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:841
CASP9GeneProductENSGALG00000001366 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:842
CDKN2AGeneProductENSGALG00000026137 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1029
CFLARGeneProductENSGALG00000008240 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8837
CHUKGeneProductENSGALG00000003289 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1147
CRADDGeneProductENSGALG00000011297 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8738
CYCSGeneProductENSGALG00000011020 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:54205
DFFAGeneProductENSGALG00000002820 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1676
DIABLOGeneProductENSGALG00000004412 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:56616
FADDGeneProductENSGALG00000007625 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8772
FASGeneProductENSGALG00000006351 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:355
GZMBGeneProductENSGALG00000044661 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3002
HELLSGeneProductENSGALG00000005451 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3070
HRKGeneProductNo homologues found for original id L:8739
IGF-IGeneProductENSGALG00000012755 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3479
IGF1RGeneProductENSGALG00000040651 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3480
IGF2GeneProductENSGALG00000035282 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3481
IKBKBGeneProductENSGALG00000031832 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3551
IKBKGGeneProductNo homologues found for original id L:8517
IRF1GeneProductENSGALG00000006785 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3659
IRF2GeneProductENSGALG00000010642 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3660
IRF3GeneProductNo homologues found for original id L:3661
IRF4GeneProductENSGALG00000043913 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3662
IRF5GeneProductENSGALG00000039982 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3663
IRF6GeneProductENSGALG00000001405 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3664
IRF7GeneProductENSGALG00000014297 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3665
JUNGeneProductENSGALG00000010870 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3725
LTAGeneProductNo homologues found for original id L:4049
MAP2K4GeneProductENSGALG00000032178 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6416
MAP3K1GeneProductENSGALG00000014718 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4214
MAPK10GeneProductENSGALG00000011109 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5602
MCL1GeneProductENSGALG00000044383 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4170
MDM2GeneProductENSGALG00000009942 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4193
MIR29AGeneProduct
MIR29B1GeneProduct
MIR29B2GeneProduct
MYCGeneProductENSGALG00000033631 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4609
NFKB1GeneProductENSGALG00000012304 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4790
NFKBIAGeneProductENSGALG00000027864 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4792
NFKBIBGeneProductENSGALG00000029691 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4793
NFKBIEGeneProductENSGALG00000044525 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4794
PIK3R1GeneProductENSGALG00000014786 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5295
PMAIP1GeneProductNo homologues found for original id L:5366
PRF1GeneProductENSGALG00000045916 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5551
RELAGeneProductENSGALG00000039409 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5970
RIPK1GeneProductENSGALG00000012827 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8737
SCAF11GeneProductENSGALG00000028849 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9169
TNFGeneProductNo homologues found for original id L:7124
TNFRSF10BGeneProductENSGALG00000000452 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8795
TNFRSF1AGeneProductENSGALG00000039461 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7132
TNFRSF1BGeneProductENSGALG00000034213 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7133
TNFRSF21GeneProductENSGALG00000016719 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:27242
TNFRSF25GeneProductENSGALG00000026499 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8718
TNFSF10GeneProductENSGALG00000009179 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8743
TNFSF6GeneProductENSGALG00000003076 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:356
TP53GeneProductNo homologues found for original id L:7157
TP63GeneProductENSGALG00000007324 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8626
TP73GeneProductENSGALG00000001006 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7161
TRADDGeneProductENSGALG00000003195 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8717
TRAF1GeneProductENSGALG00000001583 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7185
TRAF2GeneProductENSGALG00000042838 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7186
TRAF3GeneProductENSGALG00000011389 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7187

Annotated Interactions

No annotated interactions
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