Complement activation, classical pathway (Pan troglodytes)
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Complex
Formation
Ions
aggregated IgG,
IgM-antigen complex,
polyanions, RNA, DNA
lipopolysaccharides
C1 complex
Prevents Complement Attack
Membrane
attack complex
Plasma
Membrane
Proteolytic Cleavage
Cytoplasm
antigen/antibody
complex
MASP1
C1QC
C5
C4B
C3
C8A
C4A
C1QB
DAF
C1S
C7
C1QA
C6
C8B
H2O
C9
C1R
C2
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP545(r21826)
with a 64% conversion rate.
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Quality Tags
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Bibliography
No bibliography
History
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Compare
Revision
Action
Time
User
Comment
118079
view
10:43, 24 May 2021
Eweitz
Modified title
106917
view
13:39, 17 September 2019
MaintBot
HMDB identifier normalization
89192
view
03:56, 23 August 2016
Ariutta
Ontology Term : 'regulatory pathway' added !
89191
view
03:56, 23 August 2016
Ariutta
Ontology Term : 'classical complement pathway' added !
69243
view
18:35, 8 July 2013
MaintBot
Updated to 2013 gpml schema
41548
view
01:58, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34279
view
21:58, 9 December 2009
MaintBot
Automatic update of empty xrefs
33526
view
09:33, 1 December 2009
MaintBot
Removed group label
31565
view
21:56, 13 August 2009
MaintBot
Fixed text labels
30428
view
21:18, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
C1QA
GeneProduct
749231 (Entrez Gene)
update: C1QA HUMAN
C1QB
GeneProduct
469214 (Entrez Gene)
C1QC
GeneProduct
456612 (Entrez Gene)
update C1QC HUMAN
C1R
GeneProduct
466939 (Entrez Gene)
C1S
GeneProduct
451808 (Entrez Gene)
C2
GeneProduct
C3
GeneProduct
455644 (Entrez Gene)
C4A
GeneProduct
C4B
GeneProduct
462577 (Entrez Gene)
C5
GeneProduct
464703 (Entrez Gene)
C6
GeneProduct
449612 (Entrez Gene)
C7
GeneProduct
738238 (Entrez Gene)
C8A
GeneProduct
456886 (Entrez Gene)
C8B
GeneProduct
456887 (Entrez Gene)
C9
GeneProduct
DAF
GeneProduct
H2O
Metabolite
HMDB0002111 (HMDB)
MASP1
GeneProduct
460925 (Entrez Gene)
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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