Portal:IEM/PathwayAnalysis

From WikiPathways

With the pathways from the Blau book (as well as with other pathways on WikiPathways), various data analysis approaches can be performed. You can find the relevant book chapter as Open Access regarding these data approaches here: Slenter, D.N., Kutmon, M., Willighagen, E.L. (2022). WikiPathways: Integrating Pathway Knowledge with Clinical Data. In: Blau, N., Dionisi Vici, C., Ferreira, C.R., Vianey-Saban, C., van Karnebeek, C.D.M. (eds) Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases. Springer, Cham. DOI:10.1007/978-3-030-67727-5_73.

For the current overview of which pathways are covered and their status, see here.

To download all pathways tagged for Inborn Errors of Metabolsim as GPML, click here.

For example scripts (in R), please visit IEMPathwayAnalysis.

The Figure on the left shows an example of network analysis with Cytoscape, where known drug-target interactions from DrugBank using the CyTargetLinker app have been added to the purine metabolism pathway.