Alanine and aspartate metabolism (Homo sapiens)

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1, 2L-Alanyl-tRNAProteinCitrate cycle (TCA cycle)Fatty acid metabolism4.1.1.12D-Ala metabolismOxaloacetate4.1.1.11Nicotinate and nicotinamide metabolism1.2.1.184.3.2.26.1.1.71.4.3.153.5.1.35.1.1.132.6.1.14Fumarate6.3.2.112.1.3.2Glycolysis & gluconeogenesis3.5.1.16.3.1.1ASSD-aspartate4.3.1.1L-AsparagineCarnosineAcetyl-CoAUrea cycle and metabolism of amino groupsCitric acidN-Acetyl-L-aspartate3.4.13.36.1.1.222-OxosuccinamateMalonate semialdehydeMalateReductive carboxylate cycle (CO2 fixation)DARSGOT16.3.5.4Arginine and Proline metabolismASPAGOT2AGXTPantothenate and CoA biosynthesisDARSPyruvateL-Asparagine acid2.3.1.72.6.1.12ABAT6.3.4.4GPTAdenylosuccinateASLN-Carbamoyl-L-aspartate1.4.3.1L-aspartateL-Asparagine acidPC2.6.1.181.4.3.16Pyrimidine metabolismGAD2tRNA (Asn)tRNA (Asn)Selenoamino acid metabolism3.5.1.38O-AcetylcarnitineLysine biosynthesisNicotinate and nicotinamide metabolismCyanoamino acid metabolismtRNA(Asp)b-AlanineGAD1Histidine metabolismL-ArgininosuccinateSuccinateL-AlanineL-Aspartic acid3.5.1.75.1.1.1D-Alanine1.4.3.2Reductive carboxylate cycle (CO2 fixation)6.3.5.62-Oxoglutaratebeta-Alanine metabolismGlycine, serine and threonine metabolism


Description

Converted from rat to human using ortholog information, originally from KEGG. Originally edited by Sebastien Burel.

This pathway describes the metabolism of amino acids alanine and aspartate. Alanine is broken down by oxidative deamination, the inverse reaction of the reductive amination biosynthesis, catalyzed by the same enzymes.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Wu G; ''Intestinal mucosal amino acid catabolism.''; J Nutr, 1998 PubMed Europe PMC Scholia
  2. Curien G, Bastien O, Robert-Genthon M, Cornish-Bowden A, Cárdenas ML, Dumas R; ''Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters.''; Mol Syst Biol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126966view21:54, 8 July 2023EgonwAnother clickable pathway
126957view15:29, 7 July 2023DdiglesChanged ID of b-Alanine (pointed to Adrenaline), made pathway clickable.
126214view13:50, 16 April 2023EgonwLicense is CCZero
114258view13:50, 2 January 2021EgonwThree more pathways clickable
107574view05:05, 23 October 2019KhanspersModified description
107573view05:01, 23 October 2019KhanspersModified description
107115view14:19, 17 September 2019MaintBotChEBI identifier normalization
106171view12:06, 16 August 2019MaintBotHMDB identifier normalization
105875view04:49, 16 August 2019KhanspersModified description
105436view04:36, 8 August 2019KhanspersModified description
105119view22:00, 8 July 2019KhanspersModified description
102414view09:50, 23 December 2018EgonwReplaced a deleted CAS number with the active one.
94196view14:39, 25 August 2017Mkutmonadded missing metabolite identifier
92993view18:20, 21 July 2017Khanspersfixed unconnected
92992view18:17, 21 July 2017KhanspersModified description
92991view18:17, 21 July 2017Khanspersremoved GenMAPP notes
92892view18:57, 14 July 2017EgonwAdded a missing metabolite ID.
92891view18:51, 14 July 2017EgonwReplace a CAS number for a totally different compound with the ChEBI ID for L-alanine.
92890view18:51, 14 July 2017EgonwAdded a missing metabolite ID.
91240view20:15, 21 January 2017AlexanderPicoQuick edit to datanode annotation or property
89638view06:26, 22 September 2016EgonwConnected a line (the 2nd was too hard).
74147view11:26, 1 April 2014EgonwReplaced an InChI with a more traditional identifier.
71277view22:57, 16 October 2013MaintBotUpdated UniProt/TrEMBL data source
67036view09:57, 26 June 2013Christine ChichesterOntology Term : 'alanine, aspartate and glutamate metabolic pathway' added !
63140view19:17, 8 May 2013MaintBotUpdating GPML version
54702view13:23, 7 December 2012AndraRDF Tidy
53476view23:01, 7 November 2012Andra
45055view19:43, 6 October 2011AlexanderPicoadded db refs for metabolites
45039view18:57, 6 October 2011AlexanderPicoadded EC number refs
44946view12:32, 6 October 2011MartijnVanIerselOntology Term : 'amino acid metabolic pathway' added !
41117view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
38938view22:12, 24 September 2010Khanspersoverhaul of metabolites, pathway links and connectors
38933view21:50, 24 September 2010KhanspersPeriodical save, work in progress
38931view21:40, 24 September 2010KhanspersPeriodical save, work in progress
38925view21:30, 24 September 2010KhanspersPeriodical save, work in progress
38922view21:19, 24 September 2010KhanspersPeriodical save, work in progress
38921view21:09, 24 September 2010Khanspers
38826view10:24, 24 September 2010MartijnVanIersellinked pathway
38640view11:36, 23 September 2010MartijnVanIerselpathway link
35516view13:51, 12 February 2010MichielAdded ref
35424view10:53, 12 February 2010AndraAdded reference
34472view18:34, 10 December 2009MaintBotAutomatic update of empty xrefs
32205view12:40, 15 August 2009MaintBotFixed text labels
31692view11:47, 14 August 2009MaintBotFixed group labels
20905view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Alanine and aspartate metabolism KEGG]] moved to [[Pathway:WP106]]: Moved to stable identifier
14689view19:24, 23 May 2008KhanspersPeriodical save, work in progress
14686view19:14, 23 May 2008KhanspersPeriodical save, work in progress
14684view19:02, 23 May 2008Khanspersconnectors
14682view18:57, 23 May 2008Khanspersconnectors
14679view18:47, 23 May 2008KhanspersPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1.2.1.18GeneProduct1.2.1.18 (Enzyme Nomenclature)
1.4.3.1GeneProduct1.4.3.1 (Enzyme Nomenclature)
1.4.3.15GeneProduct1.4.3.15 (Enzyme Nomenclature)
1.4.3.16GeneProduct1.4.3.16 (Enzyme Nomenclature)
1.4.3.2GeneProduct1.4.3.2 (Enzyme Nomenclature)
2-OxoglutarateMetaboliteC00026 (KEGG Compound)
2-OxosuccinamateMetaboliteCHEBI:57735 (ChEBI)
2.1.3.2GeneProduct2.1.3.2 (Enzyme Nomenclature)
2.3.1.7GeneProduct2.3.1.7 (Enzyme Nomenclature)
2.6.1.12GeneProduct2.6.1.12 (Enzyme Nomenclature)
2.6.1.14GeneProduct2.6.1.14 (Enzyme Nomenclature)
2.6.1.18GeneProduct2.6.1.18 (Enzyme Nomenclature)
3.4.13.3GeneProduct3.4.13.3 (Enzyme Nomenclature)
3.5.1.1GeneProduct3.5.1.1 (Enzyme Nomenclature)
3.5.1.3GeneProduct3.5.1.3 (Enzyme Nomenclature)
3.5.1.38GeneProduct3.5.1.38 (Enzyme Nomenclature)
3.5.1.7GeneProduct3.5.1.7 (Enzyme Nomenclature)
4.1.1.11GeneProduct4.1.1.11 (Enzyme Nomenclature)
4.1.1.12GeneProduct4.1.1.12 (Enzyme Nomenclature)
4.3.1.1GeneProduct4.3.1.1 (Enzyme Nomenclature)
4.3.2.2GeneProduct4.3.2.2 (Enzyme Nomenclature)
5.1.1.13GeneProduct5.1.1.13 (Enzyme Nomenclature)
5.1.1.1GeneProduct5.1.1.1 (Enzyme Nomenclature)
6.1.1.22GeneProduct6.1.1.22 (Enzyme Nomenclature)
6.1.1.7GeneProduct6.1.1.7 (Enzyme Nomenclature)
6.3.1.1GeneProduct6.3.1.1 (Enzyme Nomenclature)
6.3.2.11GeneProduct6.3.2.11 (Enzyme Nomenclature)
6.3.4.4GeneProduct6.3.4.4 (Enzyme Nomenclature)
6.3.5.4GeneProduct6.3.5.4 (Enzyme Nomenclature)
6.3.5.6GeneProduct6.3.5.6 (Enzyme Nomenclature)
ABATGeneProduct18 (Entrez Gene)
AGXTGeneProduct189 (Entrez Gene)
ASLGeneProduct435 (Entrez Gene)
ASPAGeneProduct443 (Entrez Gene)
ASSGeneProduct445 (Entrez Gene)
Acetyl-CoAMetabolite72-89-9 (CAS) Acetyl-CoA
AdenylosuccinateMetaboliteCHEBI:15919 (ChEBI)
Arginine and Proline metabolismPathway
CarnosineMetabolite305-84-0 (CAS) Carnosine
Citric acidMetaboliteHMDB0000094 (HMDB)
Cyanoamino acid metabolismPathway
D-Ala metabolismPathway
D-AlanineMetabolite338-69-2 (CAS) D-Alanine
D-aspartateMetaboliteC00402 (KEGG Compound)
DARSGeneProduct1615 (Entrez Gene)
Fatty acid metabolismPathwayWP143 (WikiPathways)
FumarateMetaboliteC00122 (KEGG Compound)
GAD1GeneProduct2571 (Entrez Gene)
GAD2GeneProduct2572 (Entrez Gene)
GOT1GeneProduct2805 (Entrez Gene)
GOT2GeneProduct2806 (Entrez Gene)
GPTGeneProduct2875 (Entrez Gene)
Glycine, serine and threonine metabolismPathway
Glycolysis & gluconeogenesisPathwayWP534 (WikiPathways)
Histidine metabolismPathway
L-AlanineMetaboliteCHEBI:16977 (ChEBI)
L-ArgininosuccinateMetaboliteCHEBI:15682 (ChEBI)
L-Asparagine acidMetabolite70-47-3 (CAS)
L-AsparagineMetabolite70-47-3 (CAS) L-Asparagine
L-Aspartic acidMetaboliteC00049 (KEGG Compound)
L-aspartateMetaboliteC00049 (KEGG Compound)
Lysine biosynthesisPathway
MalateMetabolite6915-15-7 (CAS) (S)-Malate
Malonate semialdehydeMetaboliteCHEBI:33190 (ChEBI)
N-Acetyl-L-aspartateMetaboliteQ28000013 (Wikidata)
N-Carbamoyl-L-aspartateMetaboliteCHEBI:15859 (ChEBI)
Nicotinate and nicotinamide metabolismPathway
O-AcetylcarnitineMetabolite3040-38-8 (CAS)
OxaloacetateMetaboliteC00036 (KEGG Compound)
PCGeneProduct5091 (Entrez Gene)
Pantothenate and CoA biosynthesisPathway
Pyrimidine metabolismPathwayWP4022 (WikiPathways)
PyruvateMetaboliteCHEBI:32816 (ChEBI)
Reductive carboxylate cycle (CO2 fixation)Pathway
Selenoamino acid metabolismPathway
SuccinateMetaboliteC00042 (KEGG Compound)
Urea cycle and metabolism of amino groupsPathwayWP497 (WikiPathways)
b-AlanineMetabolite16958 (ChEBI) beta-alanine
beta-Alanine metabolismPathway
tRNA (Asn)GeneProduct
tRNA(Asp)GeneProduct

Annotated Interactions

No annotated interactions

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