Non-homologous end joining (Anopheles gambiae)

From WikiPathways

Jump to: navigation, search
Ku70NHEJ1Ku70DNA-PKcsRAD50DNA-PKcsKu70Nbs1 ?XRCC4Ku70MRE11AKu80Ku70XRCC4DNA-PKcsDNA-PKcsDNA-PKcsKu80DNA-PKcsLigase VKu80Ku70Ku80Ku70Ku80XLFKu80Ku70Ku70Ku80Ku70Ku80DNA-PKcsDNA-PKcsLigase VKu80Ku80


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 81% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
87941view13:04, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87939view13:04, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
79418view23:33, 21 March 2015Khanspersupdate schema
79417view23:32, 21 March 2015KhanspersReverted to version '22:59, 20 February 2013' by Khanspers
68437view19:10, 5 July 2013MaintBotUpdated to 2013 gpml schema
58803view22:59, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40468view18:47, 1 March 2011MaintBotRemoved redundant pathway information and comments
35402view09:54, 12 February 2010MartijnVanIerselModified description
31829view12:26, 14 August 2009MaintBotFixed group labels
30791view23:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DNA-PKcsGeneProductAGAP003967 (Ensembl)
Ku70GeneProductAGAP002690 (Ensembl)
Ku80GeneProductAGAP009910 (Ensembl)
Ligase VGeneProduct
MRE11AGeneProductAGAP006797 (Ensembl)
NHEJ1GeneProduct
Nbs1 ?GeneProduct
RAD50GeneProductAGAP003676 (Ensembl)
XLFGeneProduct
XRCC4GeneProduct

Annotated Interactions

No annotated interactions
Personal tools